Synthesis and biological activity of some very hydrophobic superagonist analogs of luteinizing hormone-releasing hormone

The effect of increased hydrophobicity at position 6 of luteinizing hormone-releasing hormone (LH-RH) has been investigated by the incorporation of a series of 15 very hydrophobic, unnatural D-amino acids at this position. The unnatural amino acids studied can be considered analogues of phenylalanin...

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Veröffentlicht in:	Journal of medicinal chemistry 1982-07, Vol.25 (7), p.795-801
Hauptverfasser:	Nestor, John J, Ho, Teresa L, Simpson, Richard A, Horner, Bonnie L, Jones, Gordon H, McRae, Georgia I, Vickery, Brian H
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids - analysis Animals Chemical Phenomena Chemistry Chromatography, High Pressure Liquid Contraceptives, Oral, Hormonal Estrus - drug effects Female Gonadotropin-Releasing Hormone - analogs & derivatives Gonadotropin-Releasing Hormone - chemical synthesis Gonadotropin-Releasing Hormone - pharmacology Peptides - chemical synthesis Population Pregnancy Rats Rats, Inbred Strains Solubility
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