The Role of Hypersensitivity Reactions to Toxoplasma Antigens in Experimental Ocular Toxoplasmosis in Nonhuman Primates
To assess the role of ocular hypersensitivity reactions to Toxoplasma antigens in previously sensitized ocular tissues, we used a nonhuman primate model of ocular toxoplasmosis. Each eye of eight monkeys was inoculated with living Toxoplasma organisms into the inner retinal layers. All eyes develope...
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| Veröffentlicht in: | American journal of ophthalmology 1982-08, Vol.94 (2), p.159-164 |
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| creator | Newman, Philip E. Ghosheh, Ribhi Tabbara, Khalid F. Richard O'Connor, G. Stern, Walter |
| description | To assess the role of ocular hypersensitivity reactions to Toxoplasma antigens in previously sensitized ocular tissues, we used a nonhuman primate model of ocular toxoplasmosis. Each eye of eight monkeys was inoculated with living Toxoplasma organisms into the inner retinal layers. All eyes developed necrotizing retinochoroiditis. Healing of the lesion occurred with the formation of a retinochoroiditic scar. Four months later, Toxoplasma antigens were injected through the right internal carotid artery. Four weeks after this, Toxoplasma antigens were inoculated into the left retina
Iritis, vitritis, and retinal edema occurred in response to the administration of the antigens, but no recurrent necrotizing retinochoroiditis was produced in this model. These findings suggested that hypersensitivity to Toxoplasma antigens does not play a major role in triggering recurrences of toxoplasmic retinochoroiditis in nonhuman primates |
| doi_str_mv | 10.1016/0002-9394(82)90070-8 |
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Iritis, vitritis, and retinal edema occurred in response to the administration of the antigens, but no recurrent necrotizing retinochoroiditis was produced in this model. These findings suggested that hypersensitivity to Toxoplasma antigens does not play a major role in triggering recurrences of toxoplasmic retinochoroiditis in nonhuman primates</description><identifier>ISSN: 0002-9394</identifier><identifier>EISSN: 1879-1891</identifier><identifier>DOI: 10.1016/0002-9394(82)90070-8</identifier><identifier>PMID: 6810699</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Animals ; antigens ; Antigens - immunology ; cell-mediated immunity ; Chorioretinitis - immunology ; Chorioretinitis - pathology ; Edema - immunology ; Eye Diseases - immunology ; Female ; Haplorhini ; Hypersensitivity - immunology ; Male ; Recurrence ; Toxoplasma ; Toxoplasma gondii ; Toxoplasmosis, Animal - immunology ; Toxoplasmosis, Ocular - immunology ; Toxoplasmosis, Ocular - pathology ; Vitreous Body - immunology</subject><ispartof>American journal of ophthalmology, 1982-08, Vol.94 (2), p.159-164</ispartof><rights>1982 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c393t-2ce6605d3a482b483da082bf05f1d4891dfa45fb235368eef7a32dfd969e5d1b3</citedby><cites>FETCH-LOGICAL-c393t-2ce6605d3a482b483da082bf05f1d4891dfa45fb235368eef7a32dfd969e5d1b3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0002939482900708$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6810699$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Newman, Philip E.</creatorcontrib><creatorcontrib>Ghosheh, Ribhi</creatorcontrib><creatorcontrib>Tabbara, Khalid F.</creatorcontrib><creatorcontrib>Richard O'Connor, G.</creatorcontrib><creatorcontrib>Stern, Walter</creatorcontrib><title>The Role of Hypersensitivity Reactions to Toxoplasma Antigens in Experimental Ocular Toxoplasmosis in Nonhuman Primates</title><title>American journal of ophthalmology</title><addtitle>Am J Ophthalmol</addtitle><description>To assess the role of ocular hypersensitivity reactions to Toxoplasma antigens in previously sensitized ocular tissues, we used a nonhuman primate model of ocular toxoplasmosis. Each eye of eight monkeys was inoculated with living Toxoplasma organisms into the inner retinal layers. All eyes developed necrotizing retinochoroiditis. Healing of the lesion occurred with the formation of a retinochoroiditic scar. Four months later, Toxoplasma antigens were injected through the right internal carotid artery. Four weeks after this, Toxoplasma antigens were inoculated into the left retina
Iritis, vitritis, and retinal edema occurred in response to the administration of the antigens, but no recurrent necrotizing retinochoroiditis was produced in this model. These findings suggested that hypersensitivity to Toxoplasma antigens does not play a major role in triggering recurrences of toxoplasmic retinochoroiditis in nonhuman primates</description><subject>Animals</subject><subject>antigens</subject><subject>Antigens - immunology</subject><subject>cell-mediated immunity</subject><subject>Chorioretinitis - immunology</subject><subject>Chorioretinitis - pathology</subject><subject>Edema - immunology</subject><subject>Eye Diseases - immunology</subject><subject>Female</subject><subject>Haplorhini</subject><subject>Hypersensitivity - immunology</subject><subject>Male</subject><subject>Recurrence</subject><subject>Toxoplasma</subject><subject>Toxoplasma gondii</subject><subject>Toxoplasmosis, Animal - immunology</subject><subject>Toxoplasmosis, Ocular - immunology</subject><subject>Toxoplasmosis, Ocular - pathology</subject><subject>Vitreous Body - immunology</subject><issn>0002-9394</issn><issn>1879-1891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkVFvFCEUhYnR1LX6DzTyZPRhFIYZBl5MmqZak8aaun0mLFxazAyswNTuv5dxN_VNny7kfufCPQehl5S8p4TyD4SQtpFMdm9F-04SMpBGPEIrKgbZUCHpY7R6QJ6iZzn_qFc-dMMROuKCEi7lCv1a3wK-iiPg6PD5bgspQ8i--DtfdvgKtCk-hoxLxOt4H7ejzpPGJ6H4m8phH_DZfRX5CULRI74086jTXzRm_wf6GsPtPOmAv1VUF8jP0ROnxwwvDvUYXX86W5-eNxeXn7-cnlw0hklWmtYA56S3THei3XSCWU3qwZHeUdvVJa3TXe82LesZFwBu0Ky1zkouobd0w47Rm_3cbYo_Z8hFTT4bGEcdIM5ZDR2Vywv_BWnfc8p7WsFuD5oUc07g1HbZKe0UJWoJRi2uq8V1JWpdglGiyl4d5s-bCeyD6JBE7b_e952OSt8kn9X195ZQRloqh6FbJnzcE1D9uvOQVDYeggHrE5iibPT__sJvx6eoMg</recordid><startdate>198208</startdate><enddate>198208</enddate><creator>Newman, Philip E.</creator><creator>Ghosheh, Ribhi</creator><creator>Tabbara, Khalid F.</creator><creator>Richard O'Connor, G.</creator><creator>Stern, Walter</creator><general>Elsevier Inc</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>198208</creationdate><title>The Role of Hypersensitivity Reactions to Toxoplasma Antigens in Experimental Ocular Toxoplasmosis in Nonhuman Primates</title><author>Newman, Philip E. ; Ghosheh, Ribhi ; Tabbara, Khalid F. ; Richard O'Connor, G. ; Stern, Walter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c393t-2ce6605d3a482b483da082bf05f1d4891dfa45fb235368eef7a32dfd969e5d1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>antigens</topic><topic>Antigens - immunology</topic><topic>cell-mediated immunity</topic><topic>Chorioretinitis - immunology</topic><topic>Chorioretinitis - pathology</topic><topic>Edema - immunology</topic><topic>Eye Diseases - immunology</topic><topic>Female</topic><topic>Haplorhini</topic><topic>Hypersensitivity - immunology</topic><topic>Male</topic><topic>Recurrence</topic><topic>Toxoplasma</topic><topic>Toxoplasma gondii</topic><topic>Toxoplasmosis, Animal - immunology</topic><topic>Toxoplasmosis, Ocular - immunology</topic><topic>Toxoplasmosis, Ocular - pathology</topic><topic>Vitreous Body - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Newman, Philip E.</creatorcontrib><creatorcontrib>Ghosheh, Ribhi</creatorcontrib><creatorcontrib>Tabbara, Khalid F.</creatorcontrib><creatorcontrib>Richard O'Connor, G.</creatorcontrib><creatorcontrib>Stern, Walter</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of ophthalmology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Newman, Philip E.</au><au>Ghosheh, Ribhi</au><au>Tabbara, Khalid F.</au><au>Richard O'Connor, G.</au><au>Stern, Walter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Role of Hypersensitivity Reactions to Toxoplasma Antigens in Experimental Ocular Toxoplasmosis in Nonhuman Primates</atitle><jtitle>American journal of ophthalmology</jtitle><addtitle>Am J Ophthalmol</addtitle><date>1982-08</date><risdate>1982</risdate><volume>94</volume><issue>2</issue><spage>159</spage><epage>164</epage><pages>159-164</pages><issn>0002-9394</issn><eissn>1879-1891</eissn><abstract>To assess the role of ocular hypersensitivity reactions to Toxoplasma antigens in previously sensitized ocular tissues, we used a nonhuman primate model of ocular toxoplasmosis. Each eye of eight monkeys was inoculated with living Toxoplasma organisms into the inner retinal layers. All eyes developed necrotizing retinochoroiditis. Healing of the lesion occurred with the formation of a retinochoroiditic scar. Four months later, Toxoplasma antigens were injected through the right internal carotid artery. Four weeks after this, Toxoplasma antigens were inoculated into the left retina
Iritis, vitritis, and retinal edema occurred in response to the administration of the antigens, but no recurrent necrotizing retinochoroiditis was produced in this model. These findings suggested that hypersensitivity to Toxoplasma antigens does not play a major role in triggering recurrences of toxoplasmic retinochoroiditis in nonhuman primates</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6810699</pmid><doi>10.1016/0002-9394(82)90070-8</doi><tpages>6</tpages></addata></record> |
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| ispartof | American journal of ophthalmology, 1982-08, Vol.94 (2), p.159-164 |
| issn | 0002-9394 1879-1891 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals antigens Antigens - immunology cell-mediated immunity Chorioretinitis - immunology Chorioretinitis - pathology Edema - immunology Eye Diseases - immunology Female Haplorhini Hypersensitivity - immunology Male Recurrence Toxoplasma Toxoplasma gondii Toxoplasmosis, Animal - immunology Toxoplasmosis, Ocular - immunology Toxoplasmosis, Ocular - pathology Vitreous Body - immunology |
| title | The Role of Hypersensitivity Reactions to Toxoplasma Antigens in Experimental Ocular Toxoplasmosis in Nonhuman Primates |
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