Dose-related effects of the synthetic met-enkephalin analogue FK 33-824 on esophageal motor activity in healthy humans

The effects of FK 33-824, a methionine enkephalin analogue, 313, 625, 1250, 2500, and 5000 ng/kg body wt intramuscularly, on esophageal motor activity and cardiovascular and central nervous functions were studied in 8 healthy men. In the lower one-third of the esophagus, amplitude and duration of sw...

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Veröffentlicht in:	Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 1982-11, Vol.83 (5), p.1057-1061
Hauptverfasser:	Stacher, G, Bauer, P, Steinringer, H, Schmierer, G, Langer, B, Winklehner, S
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Blood Pressure - drug effects D-Ala,MePhe,Met-ol-enkephalin Deglutition - drug effects Dose-Response Relationship, Drug Electroencephalography Enkephalin, Methionine - analogs & derivatives Enkephalin, Methionine - pharmacology Esophagus - drug effects Heart Rate - drug effects Humans Male Manometry Muscle Contraction - drug effects Muscle, Smooth - drug effects Respiration - drug effects
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