The incidence and influence of antisperm antibodies in infertile human couples on sperm-cervical mucus interactions and subsequent fertility
Analysis of serum samples from 698 infertile couples revealed antisperm antibodies present in 16.5% of the men and 21.6% of the women. Overall, 31.1% of the couples possessed at least one individual with positive results. Sperm-immobilizing activity was detected in 29.6% of the cervical mucus (CM) s...
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| Veröffentlicht in: | Fertility and sterility 1982-10, Vol.38 (4), p.439-446 |
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| container_title | Fertility and sterility |
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| creator | Menge, Alan C. Medley, Nadine E. Mangione, Carol M. Dietrich, John W. |
| description | Analysis of serum samples from 698 infertile couples revealed antisperm antibodies present in 16.5% of the men and 21.6% of the women. Overall, 31.1% of the couples possessed at least one individual with positive results. Sperm-immobilizing activity was detected in 29.6% of the cervical mucus (CM) samples from 459 women. Reduced sperm penetration of CM was significantly associated with serum titers of antisperm antibodies in both sexes and also with immobilizing activity in CM of women. The incidence of subsequent pregnancy in 376 infertile couples was reduced significantly if one or both partners had antisperm antibodies in serum or in genital tract secretions. The latter was reflected by evaluation of the immobilization, penetration, and shaking phenomenon of sperm in CM. |
| doi_str_mv | 10.1016/S0015-0282(16)46578-7 |
| format | Article |
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Overall, 31.1% of the couples possessed at least one individual with positive results. Sperm-immobilizing activity was detected in 29.6% of the cervical mucus (CM) samples from 459 women. Reduced sperm penetration of CM was significantly associated with serum titers of antisperm antibodies in both sexes and also with immobilizing activity in CM of women. The incidence of subsequent pregnancy in 376 infertile couples was reduced significantly if one or both partners had antisperm antibodies in serum or in genital tract secretions. 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The latter was reflected by evaluation of the immobilization, penetration, and shaking phenomenon of sperm in CM.</description><subject>Antibodies - analysis</subject><subject>Autoantibodies - analysis</subject><subject>Cervix Mucus - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Infertility - immunology</subject><subject>Male</subject><subject>Population</subject><subject>Pregnancy</subject><subject>Sperm Agglutination</subject><subject>Sperm Motility</subject><subject>Spermatozoa - immunology</subject><issn>0015-0282</issn><issn>1556-5653</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctq3TAQFaUlvU37CQGvSrtwo5Gtx12VEvqCQBZJ1kKWRkTFtm4lOZB_yEdX9r1k25U0c87Mkc4h5ALoF6AgLm8pBd5SptgnEJ97waVq5SuyA85FywXvXpPdC-UteZfzH0qpAMnOyJkEkFzCjjzfPWATZhsczhYbM7ta-XHZquhro4R8wDRttyG6gLkyVhKmEkZsHpbJzI2Ny2GsUJybjd5aTI_BmrGZFrusIwWTsSXEOW8qeRky_q06pTluCuXpPXnjzZjxw-k8J_c_vt9d_Wqvb37-vvp23VomeWmZAG_ZMKheAfRMOGDKWGWGPSjPB7O3XinlAKmnPUXbMW85VVI474desu6cfDzuPaRYn5CLnkK2OI5mxrhkLXvYdwBdJfIj0aaYc0KvDylMJj1poHpNQW8p6NViXastBS3r3MVJYBkmdC9TJ9sr_vWIY_3lY8Cksw2r5S4ktEW7GP6j8A-PT5rB</recordid><startdate>198210</startdate><enddate>198210</enddate><creator>Menge, Alan C.</creator><creator>Medley, Nadine E.</creator><creator>Mangione, Carol M.</creator><creator>Dietrich, John W.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198210</creationdate><title>The incidence and influence of antisperm antibodies in infertile human couples on sperm-cervical mucus interactions and subsequent fertility</title><author>Menge, Alan C. ; Medley, Nadine E. ; Mangione, Carol M. ; Dietrich, John W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c275t-261fc2bb84811426d128ac8ab918f5ba9cf888d1e0f040ec32fc50876dffb4723</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Antibodies - analysis</topic><topic>Autoantibodies - analysis</topic><topic>Cervix Mucus - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Infertility - immunology</topic><topic>Male</topic><topic>Population</topic><topic>Pregnancy</topic><topic>Sperm Agglutination</topic><topic>Sperm Motility</topic><topic>Spermatozoa - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Menge, Alan C.</creatorcontrib><creatorcontrib>Medley, Nadine E.</creatorcontrib><creatorcontrib>Mangione, Carol M.</creatorcontrib><creatorcontrib>Dietrich, John W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Fertility and sterility</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Menge, Alan C.</au><au>Medley, Nadine E.</au><au>Mangione, Carol M.</au><au>Dietrich, John W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The incidence and influence of antisperm antibodies in infertile human couples on sperm-cervical mucus interactions and subsequent fertility</atitle><jtitle>Fertility and sterility</jtitle><addtitle>Fertil Steril</addtitle><date>1982-10</date><risdate>1982</risdate><volume>38</volume><issue>4</issue><spage>439</spage><epage>446</epage><pages>439-446</pages><issn>0015-0282</issn><eissn>1556-5653</eissn><abstract>Analysis of serum samples from 698 infertile couples revealed antisperm antibodies present in 16.5% of the men and 21.6% of the women. Overall, 31.1% of the couples possessed at least one individual with positive results. Sperm-immobilizing activity was detected in 29.6% of the cervical mucus (CM) samples from 459 women. Reduced sperm penetration of CM was significantly associated with serum titers of antisperm antibodies in both sexes and also with immobilizing activity in CM of women. The incidence of subsequent pregnancy in 376 infertile couples was reduced significantly if one or both partners had antisperm antibodies in serum or in genital tract secretions. The latter was reflected by evaluation of the immobilization, penetration, and shaking phenomenon of sperm in CM.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7117571</pmid><doi>10.1016/S0015-0282(16)46578-7</doi><tpages>8</tpages></addata></record> |
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| ispartof | Fertility and sterility, 1982-10, Vol.38 (4), p.439-446 |
| issn | 0015-0282 1556-5653 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | Antibodies - analysis Autoantibodies - analysis Cervix Mucus - immunology Female Humans Infertility - immunology Male Population Pregnancy Sperm Agglutination Sperm Motility Spermatozoa - immunology |
| title | The incidence and influence of antisperm antibodies in infertile human couples on sperm-cervical mucus interactions and subsequent fertility |
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