The nylon wool adherence marker of the B cell lineage appears at the resting pre‐B cell stage
The proliferative state of functionally defined populations of size‐separated pre‐B cells was investigated. The results presented here support the hypothesis that pre‐B cells are in the G2 phase when stable membrane IgM is first expressed. Small resting precursor cells significantly adhere to nylon...
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| Veröffentlicht in: | European journal of immunology 1982, Vol.12 (4), p.285-289 |
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| container_end_page | 289 |
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| container_issue | 4 |
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| container_title | European journal of immunology |
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| creator | Deslauriers‐Boisvert, Noélla Mercier, Ginette Lafleur, Louis |
| description | The proliferative state of functionally defined populations of size‐separated pre‐B cells was investigated. The results presented here support the hypothesis that pre‐B cells are in the G2 phase when stable membrane IgM is first expressed. Small resting precursor cells significantly adhere to nylon wool columns, unlike larger cycling cells which can be enriched in the nonadherent fraction. These results suggest that the nylon wool “receptor” is a useful early B cell marker.
Since the in vitro recruitment of both cycling and resting precursors was shown to be essentially dependent on agar mitogen(s), cumulative data suggest that the receptors for agar mitogen(s) appear shortly before surface IgM on proliferating pre‐B cells. Nylon wool adherence potential develops next on their resting progeny, followed by full lipopolysaccharide reactivity as cells further mature. |
| doi_str_mv | 10.1002/eji.1830120406 |
| format | Article |
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Since the in vitro recruitment of both cycling and resting precursors was shown to be essentially dependent on agar mitogen(s), cumulative data suggest that the receptors for agar mitogen(s) appear shortly before surface IgM on proliferating pre‐B cells. Nylon wool adherence potential develops next on their resting progeny, followed by full lipopolysaccharide reactivity as cells further mature.</description><identifier>ISSN: 0014-2980</identifier><identifier>EISSN: 1521-4141</identifier><identifier>DOI: 10.1002/eji.1830120406</identifier><identifier>PMID: 6980120</identifier><language>eng</language><publisher>Weinheim: WILEY‐VCH Verlag GmbH</publisher><subject>Animals ; B-Lymphocytes - classification ; B-Lymphocytes - cytology ; B-Lymphocytes - immunology ; Bone Marrow Cells ; Cell Adhesion ; Cell Cycle ; Cell Differentiation ; Cell Separation ; Colony-Forming Units Assay ; Culture Media ; Female ; Hematopoietic Stem Cells - cytology ; Hematopoietic Stem Cells - immunology ; Immunoglobulin M - biosynthesis ; Immunologic Capping ; Male ; Mice ; Mice, Inbred C3H ; Rats ; Rats, Inbred Strains ; Receptors, Antigen, B-Cell - biosynthesis</subject><ispartof>European journal of immunology, 1982, Vol.12 (4), p.285-289</ispartof><rights>Copyright © 1982 WILEY‐VCH Verlag GmbH & Co. KGaA</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3406-25db38a86aaeb927d46cea37860641c9ebd57252d6fb64132bb042bde385c8da3</citedby><cites>FETCH-LOGICAL-c3406-25db38a86aaeb927d46cea37860641c9ebd57252d6fb64132bb042bde385c8da3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Feji.1830120406$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Feji.1830120406$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,4010,27900,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6980120$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Deslauriers‐Boisvert, Noélla</creatorcontrib><creatorcontrib>Mercier, Ginette</creatorcontrib><creatorcontrib>Lafleur, Louis</creatorcontrib><title>The nylon wool adherence marker of the B cell lineage appears at the resting pre‐B cell stage</title><title>European journal of immunology</title><addtitle>Eur J Immunol</addtitle><description>The proliferative state of functionally defined populations of size‐separated pre‐B cells was investigated. The results presented here support the hypothesis that pre‐B cells are in the G2 phase when stable membrane IgM is first expressed. Small resting precursor cells significantly adhere to nylon wool columns, unlike larger cycling cells which can be enriched in the nonadherent fraction. These results suggest that the nylon wool “receptor” is a useful early B cell marker.
Since the in vitro recruitment of both cycling and resting precursors was shown to be essentially dependent on agar mitogen(s), cumulative data suggest that the receptors for agar mitogen(s) appear shortly before surface IgM on proliferating pre‐B cells. Nylon wool adherence potential develops next on their resting progeny, followed by full lipopolysaccharide reactivity as cells further mature.</description><subject>Animals</subject><subject>B-Lymphocytes - classification</subject><subject>B-Lymphocytes - cytology</subject><subject>B-Lymphocytes - immunology</subject><subject>Bone Marrow Cells</subject><subject>Cell Adhesion</subject><subject>Cell Cycle</subject><subject>Cell Differentiation</subject><subject>Cell Separation</subject><subject>Colony-Forming Units Assay</subject><subject>Culture Media</subject><subject>Female</subject><subject>Hematopoietic Stem Cells - cytology</subject><subject>Hematopoietic Stem Cells - immunology</subject><subject>Immunoglobulin M - biosynthesis</subject><subject>Immunologic Capping</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Receptors, Antigen, B-Cell - biosynthesis</subject><issn>0014-2980</issn><issn>1521-4141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkL1OwzAUhS0EKqWwsiF5YkvxX5xkhKpAUSWWMlt2fNOmpEmwW1XdeASekSfBpRGwMV3pnu8enXsQuqRkSAlhN7AshzTlhDIiiDxCfRozGgkq6DHqE0JFxLKUnKIz75eEkEzGWQ_1ZNiFiz5SswXgelc1Nd42TYW1XYCDOge80u4VHG4KvA7IHc6hqnBV1qDngHXbgnYe6_W36sCvy3qOWwef7x8d69eBPEcnha48XHRzgF7ux7PRYzR9fpiMbqdRzkPsiMXW8FSnUmswGUuskDlonqSSSEHzDIyNExYzKwsTFpwZQwQzFnga56nVfICuD76ta942IY5alX4fQ9fQbLxKBE0zwngAhwcwd433DgrVujL8ulOUqH2jKjSqfhsNB1ed88aswP7gXYVBzw76tqxg94-bGj9N_nh_AfZ-gl4</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Deslauriers‐Boisvert, Noélla</creator><creator>Mercier, Ginette</creator><creator>Lafleur, Louis</creator><general>WILEY‐VCH Verlag GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1982</creationdate><title>The nylon wool adherence marker of the B cell lineage appears at the resting pre‐B cell stage</title><author>Deslauriers‐Boisvert, Noélla ; Mercier, Ginette ; Lafleur, Louis</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3406-25db38a86aaeb927d46cea37860641c9ebd57252d6fb64132bb042bde385c8da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>B-Lymphocytes - classification</topic><topic>B-Lymphocytes - cytology</topic><topic>B-Lymphocytes - immunology</topic><topic>Bone Marrow Cells</topic><topic>Cell Adhesion</topic><topic>Cell Cycle</topic><topic>Cell Differentiation</topic><topic>Cell Separation</topic><topic>Colony-Forming Units Assay</topic><topic>Culture Media</topic><topic>Female</topic><topic>Hematopoietic Stem Cells - cytology</topic><topic>Hematopoietic Stem Cells - immunology</topic><topic>Immunoglobulin M - biosynthesis</topic><topic>Immunologic Capping</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred C3H</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Receptors, Antigen, B-Cell - biosynthesis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Deslauriers‐Boisvert, Noélla</creatorcontrib><creatorcontrib>Mercier, Ginette</creatorcontrib><creatorcontrib>Lafleur, Louis</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Deslauriers‐Boisvert, Noélla</au><au>Mercier, Ginette</au><au>Lafleur, Louis</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The nylon wool adherence marker of the B cell lineage appears at the resting pre‐B cell stage</atitle><jtitle>European journal of immunology</jtitle><addtitle>Eur J Immunol</addtitle><date>1982</date><risdate>1982</risdate><volume>12</volume><issue>4</issue><spage>285</spage><epage>289</epage><pages>285-289</pages><issn>0014-2980</issn><eissn>1521-4141</eissn><abstract>The proliferative state of functionally defined populations of size‐separated pre‐B cells was investigated. The results presented here support the hypothesis that pre‐B cells are in the G2 phase when stable membrane IgM is first expressed. Small resting precursor cells significantly adhere to nylon wool columns, unlike larger cycling cells which can be enriched in the nonadherent fraction. These results suggest that the nylon wool “receptor” is a useful early B cell marker.
Since the in vitro recruitment of both cycling and resting precursors was shown to be essentially dependent on agar mitogen(s), cumulative data suggest that the receptors for agar mitogen(s) appear shortly before surface IgM on proliferating pre‐B cells. Nylon wool adherence potential develops next on their resting progeny, followed by full lipopolysaccharide reactivity as cells further mature.</abstract><cop>Weinheim</cop><pub>WILEY‐VCH Verlag GmbH</pub><pmid>6980120</pmid><doi>10.1002/eji.1830120406</doi><tpages>5</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0014-2980 |
| ispartof | European journal of immunology, 1982, Vol.12 (4), p.285-289 |
| issn | 0014-2980 1521-4141 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74189023 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals B-Lymphocytes - classification B-Lymphocytes - cytology B-Lymphocytes - immunology Bone Marrow Cells Cell Adhesion Cell Cycle Cell Differentiation Cell Separation Colony-Forming Units Assay Culture Media Female Hematopoietic Stem Cells - cytology Hematopoietic Stem Cells - immunology Immunoglobulin M - biosynthesis Immunologic Capping Male Mice Mice, Inbred C3H Rats Rats, Inbred Strains Receptors, Antigen, B-Cell - biosynthesis |
| title | The nylon wool adherence marker of the B cell lineage appears at the resting pre‐B cell stage |
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