Fasting-induced torpor in Mus musculus and its implications in the use of murine models for human obesity studies
1. 1. Fasting at room temperature for 24–48 hr can induce shallow daily torpor in mice of several strains. 2. 2. Genetically-obese (ob/ob) C57B1/6 mice show torpor even in the presence of food. 3. 3. Chemically-obese (gold-thioglucose or bipiperidyl mustard) mice of C57B1/6 and T/O strains appear re...
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| Veröffentlicht in: | Comparative biochemistry and physiology. A, Comparative physiology Comparative physiology, 1982, Vol.72 (1), p.211-219 |
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| container_title | Comparative biochemistry and physiology. A, Comparative physiology |
| container_volume | 72 |
| creator | Webb, G.P Jagot, S.A Jakobson, M.E |
| description | 1.
1. Fasting at room temperature for 24–48 hr can induce shallow daily torpor in mice of several strains.
2.
2. Genetically-obese (ob/ob) C57B1/6 mice show torpor even in the presence of food.
3.
3. Chemically-obese (gold-thioglucose or bipiperidyl mustard) mice of C57B1/6 and T/O strains appear resistant to torpor.
4.
4. During cold acclimation (3–5°) fasting also induces torpor in lean mice, with gradually improving rates of arousal.
5.
5. In acute cold shock (3–5°), previously weight-reduced ob/ob mice show resistance to change in body temperature, while control ob/ob mice drift immediately towards hypothermia. |
| doi_str_mv | 10.1016/0300-9629(82)90035-4 |
| format | Article |
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1. Fasting at room temperature for 24–48 hr can induce shallow daily torpor in mice of several strains.
2.
2. Genetically-obese (ob/ob) C57B1/6 mice show torpor even in the presence of food.
3.
3. Chemically-obese (gold-thioglucose or bipiperidyl mustard) mice of C57B1/6 and T/O strains appear resistant to torpor.
4.
4. During cold acclimation (3–5°) fasting also induces torpor in lean mice, with gradually improving rates of arousal.
5.
5. In acute cold shock (3–5°), previously weight-reduced ob/ob mice show resistance to change in body temperature, while control ob/ob mice drift immediately towards hypothermia.</description><identifier>ISSN: 0300-9629</identifier><identifier>DOI: 10.1016/0300-9629(82)90035-4</identifier><identifier>PMID: 6124358</identifier><language>eng</language><publisher>England: Elsevier B.V</publisher><subject>Adaptation, Physiological ; Animals ; Body Temperature Regulation ; Cold Temperature ; diet-related diseases ; Disease Models, Animal ; Fasting ; human nutrition ; Humans ; Hypothermia - physiopathology ; Mice ; Mice, Inbred Strains ; Mice, Obese - physiology ; Obesity - physiopathology ; Sleep Stages</subject><ispartof>Comparative biochemistry and physiology. A, Comparative physiology, 1982, Vol.72 (1), p.211-219</ispartof><rights>1982</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-ed11a88884659634d6102435e7fa5fbf171260d54ca6e53672e0a25b0f2e3d213</citedby><cites>FETCH-LOGICAL-c447t-ed11a88884659634d6102435e7fa5fbf171260d54ca6e53672e0a25b0f2e3d213</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6124358$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Webb, G.P</creatorcontrib><creatorcontrib>Jagot, S.A</creatorcontrib><creatorcontrib>Jakobson, M.E</creatorcontrib><title>Fasting-induced torpor in Mus musculus and its implications in the use of murine models for human obesity studies</title><title>Comparative biochemistry and physiology. A, Comparative physiology</title><addtitle>Comp Biochem Physiol A Comp Physiol</addtitle><description>1.
1. Fasting at room temperature for 24–48 hr can induce shallow daily torpor in mice of several strains.
2.
2. Genetically-obese (ob/ob) C57B1/6 mice show torpor even in the presence of food.
3.
3. Chemically-obese (gold-thioglucose or bipiperidyl mustard) mice of C57B1/6 and T/O strains appear resistant to torpor.
4.
4. During cold acclimation (3–5°) fasting also induces torpor in lean mice, with gradually improving rates of arousal.
5.
5. In acute cold shock (3–5°), previously weight-reduced ob/ob mice show resistance to change in body temperature, while control ob/ob mice drift immediately towards hypothermia.</description><subject>Adaptation, Physiological</subject><subject>Animals</subject><subject>Body Temperature Regulation</subject><subject>Cold Temperature</subject><subject>diet-related diseases</subject><subject>Disease Models, Animal</subject><subject>Fasting</subject><subject>human nutrition</subject><subject>Humans</subject><subject>Hypothermia - physiopathology</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Mice, Obese - physiology</subject><subject>Obesity - physiopathology</subject><subject>Sleep Stages</subject><issn>0300-9629</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU1v1DAQhn0AlbLwD0D4hOAQ8Fec5IJUVRSQijhAz5bXnrRGib312Ej99zjsqkd8seV55tXoGUJecfaBM64_MslYN2kxvRvF-4kx2XfqCTl__H5GniP-Zoxxyfszcqa5ULIfz8n9lcUS4m0Xoq8OPC0pH1KmIdLvFela0dWlPWz0NBSkYT0swdkSUsQNKndAKwJNc2NziEDX5GFBOreQu7raSNMeMJQHiqX6APiCPJ3tgvDydO_IzdXnX5dfu-sfX75dXlx3TqmhdOA5t2M7SveTlsprzraZYZhtP-9nPnChme-Vsxp6qQcBzIp-z2YB0gsud-TtMfeQ030FLGYN6GBZbIRU0QyKj3pkqoHqCLqcEDPM5pDDavOD4cxsds2m0WwazSjMP7tma3t9yq_7Ffxj00ltq7851mebjL3NAc3NT9EWwPg0yrGl7MinI9F8wZ8A2aALENsWQgZXjE_h_yP8Bb3DlOw</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>Webb, G.P</creator><creator>Jagot, S.A</creator><creator>Jakobson, M.E</creator><general>Elsevier B.V</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1982</creationdate><title>Fasting-induced torpor in Mus musculus and its implications in the use of murine models for human obesity studies</title><author>Webb, G.P ; Jagot, S.A ; Jakobson, M.E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-ed11a88884659634d6102435e7fa5fbf171260d54ca6e53672e0a25b0f2e3d213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adaptation, Physiological</topic><topic>Animals</topic><topic>Body Temperature Regulation</topic><topic>Cold Temperature</topic><topic>diet-related diseases</topic><topic>Disease Models, Animal</topic><topic>Fasting</topic><topic>human nutrition</topic><topic>Humans</topic><topic>Hypothermia - physiopathology</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Mice, Obese - physiology</topic><topic>Obesity - physiopathology</topic><topic>Sleep Stages</topic><toplevel>online_resources</toplevel><creatorcontrib>Webb, G.P</creatorcontrib><creatorcontrib>Jagot, S.A</creatorcontrib><creatorcontrib>Jakobson, M.E</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Comparative biochemistry and physiology. A, Comparative physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Webb, G.P</au><au>Jagot, S.A</au><au>Jakobson, M.E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fasting-induced torpor in Mus musculus and its implications in the use of murine models for human obesity studies</atitle><jtitle>Comparative biochemistry and physiology. A, Comparative physiology</jtitle><addtitle>Comp Biochem Physiol A Comp Physiol</addtitle><date>1982</date><risdate>1982</risdate><volume>72</volume><issue>1</issue><spage>211</spage><epage>219</epage><pages>211-219</pages><issn>0300-9629</issn><abstract>1.
1. Fasting at room temperature for 24–48 hr can induce shallow daily torpor in mice of several strains.
2.
2. Genetically-obese (ob/ob) C57B1/6 mice show torpor even in the presence of food.
3.
3. Chemically-obese (gold-thioglucose or bipiperidyl mustard) mice of C57B1/6 and T/O strains appear resistant to torpor.
4.
4. During cold acclimation (3–5°) fasting also induces torpor in lean mice, with gradually improving rates of arousal.
5.
5. In acute cold shock (3–5°), previously weight-reduced ob/ob mice show resistance to change in body temperature, while control ob/ob mice drift immediately towards hypothermia.</abstract><cop>England</cop><pub>Elsevier B.V</pub><pmid>6124358</pmid><doi>10.1016/0300-9629(82)90035-4</doi><tpages>9</tpages></addata></record> |
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| ispartof | Comparative biochemistry and physiology. A, Comparative physiology, 1982, Vol.72 (1), p.211-219 |
| issn | 0300-9629 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74186804 |
| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adaptation, Physiological Animals Body Temperature Regulation Cold Temperature diet-related diseases Disease Models, Animal Fasting human nutrition Humans Hypothermia - physiopathology Mice Mice, Inbred Strains Mice, Obese - physiology Obesity - physiopathology Sleep Stages |
| title | Fasting-induced torpor in Mus musculus and its implications in the use of murine models for human obesity studies |
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