Reduction of nitroimidazoles in model chemical and biological systems

Some chemical and biological properties of intermediates obtained during reduction of nitroimidazoles are discussed. These include: rate data for the decay of the nitro radical-anion, stoichiometry and absorption spectra for reduction via the radical-anion or using dithionite, stoichiometry with oth...

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Veröffentlicht in:	Int. J. Radiat. Oncol., Biol. Phys.; (United States) Biol. Phys.; (United States), 1982-03, Vol.8 (3), p.777-780
Hauptverfasser:	Wardman, P., Anderson, R.F., Clarke, E.D., Phil, M., Jones, N.R., Minchinton, A.I., Patel, K.B., Stratford, M.R.L., Watts, M.E.
Format:	Artikel
Sprache:	eng
Schlagworte:	560302 > Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987) ABSORPTION SPECTRA AMINES Animals AZOLES BACTERIA Cells, Cultured Chemical Phenomena CHEMICAL REACTIONS Chemistry Drug Stability ENZYMES ESCHERICHIA COLI Escherichia coli - metabolism Hepatic metabolism HETEROCYCLIC COMPOUNDS HYDROXYLAMINE Hydroxylamines IMIDAZOLES In Vitro Techniques Kinetics Liver - metabolism Metabolic potentiation of radiosensitization METABOLITES Mice MICROORGANISMS Models, Chemical NITRO COMPOUNDS NITRO-GROUP DEHYDROGENASES Nitroimidazoles - metabolism Nitroimidazoles - pharmacology Nitroreductases ORGANIC COMPOUNDS ORGANIC NITROGEN COMPOUNDS Oxidation-Reduction OXIDOREDUCTASES OXYGENASES RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT Radiation-Sensitizing Agents - metabolism Radical-anion RADIOSENSITIVITY EFFECTS REDUCTION Reduction of nitroimidazoles Reduction stoichiometry SPECTRA 560131 > Radiation Effects on Microorganisms-- Basic Studies-- (-1987) STOICHIOMETRY Xanthine oxidase
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