Mouse gallbladder emptying by egg yolk: A possible new rapid method for antispasmodic activity evaluation in vivo
Gallbladder emptying was induced in female albino mice by single oral administrations of 30% lyophylized egg yolk suspension. Mice were killed 15 min later, their gallbladders removed and then weighed. Gallbladder emptying was assessed by comparing weights from control and egg yolk administered mice...
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| Veröffentlicht in: | Journal of pharmacological methods 1982-05, Vol.7 (3), p.193-195 |
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| container_title | Journal of pharmacological methods |
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| creator | Valsecchi, Bruno Toson, Giancarlo |
| description | Gallbladder emptying was induced in female albino mice by single oral administrations of 30% lyophylized egg yolk suspension. Mice were killed 15 min later, their gallbladders removed and then weighed. Gallbladder emptying was assessed by comparing weights from control and egg yolk administered mice. The ability of the antispasmodic drugs atropine,
N-butylscopolamine, papaverine, trimebutine, dicyclomine, and rociverine to delay gallbladder emptying was determined by administering them either intraperitoneally or orally 7.5 or 15 min prior to egg yolk. |
| doi_str_mv | 10.1016/0160-5402(82)90035-3 |
| format | Article |
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N-butylscopolamine, papaverine, trimebutine, dicyclomine, and rociverine to delay gallbladder emptying was determined by administering them either intraperitoneally or orally 7.5 or 15 min prior to egg yolk.</description><identifier>ISSN: 0160-5402</identifier><identifier>DOI: 10.1016/0160-5402(82)90035-3</identifier><identifier>PMID: 7109644</identifier><language>eng</language><publisher>United States: Elsevier B.V</publisher><subject>Administration, Oral ; Animals ; Antispasmodic drugs ; Drug Evaluation, Preclinical - methods ; effect of ; Egg Yolk ; Female ; Gallbladder - drug effects ; Gallbladder emptying ; Injections, Intraperitoneal ; Mice ; Parasympatholytics - pharmacology</subject><ispartof>Journal of pharmacological methods, 1982-05, Vol.7 (3), p.193-195</ispartof><rights>1982</rights><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c272t-92fc1724ce37f3d264ae7918ef766a5a6b146b35a8f2ecdfab0a6c6f28f51d93</citedby><cites>FETCH-LOGICAL-c272t-92fc1724ce37f3d264ae7918ef766a5a6b146b35a8f2ecdfab0a6c6f28f51d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7109644$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Valsecchi, Bruno</creatorcontrib><creatorcontrib>Toson, Giancarlo</creatorcontrib><title>Mouse gallbladder emptying by egg yolk: A possible new rapid method for antispasmodic activity evaluation in vivo</title><title>Journal of pharmacological methods</title><addtitle>J Pharmacol Methods</addtitle><description>Gallbladder emptying was induced in female albino mice by single oral administrations of 30% lyophylized egg yolk suspension. Mice were killed 15 min later, their gallbladders removed and then weighed. Gallbladder emptying was assessed by comparing weights from control and egg yolk administered mice. The ability of the antispasmodic drugs atropine,
N-butylscopolamine, papaverine, trimebutine, dicyclomine, and rociverine to delay gallbladder emptying was determined by administering them either intraperitoneally or orally 7.5 or 15 min prior to egg yolk.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Antispasmodic drugs</subject><subject>Drug Evaluation, Preclinical - methods</subject><subject>effect of</subject><subject>Egg Yolk</subject><subject>Female</subject><subject>Gallbladder - drug effects</subject><subject>Gallbladder emptying</subject><subject>Injections, Intraperitoneal</subject><subject>Mice</subject><subject>Parasympatholytics - pharmacology</subject><issn>0160-5402</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9v1DAQxX0oasvCNyiSTwgOAf9JnIQDUlVBi1TEpXdrYo-3BidObW-q_fZk2VWPHEYjzZt5o_cj5IqzT5xx9XktVjU1Ex868bFnTDaVPCOXL-ML8jrn34wJLqU4J-ctZ72q60vy9DPuMtIthDAEsBYTxXEuez9t6bCnuN3SfQx_vtBrOsec_RCQTvhME8ze0hHLY7TUxURhKj7PkMdovaFgil98WQ0WCDsoPk7UT3TxS3xDXjkIGd-e-oY8fP_2cHNX3f-6_XFzfV8Z0YpS9cIZ3oraoGydtELVgG3PO3StUtCAGnitBtlA5wQa62BgoIxyonMNt73ckPdH2znFpx3mokefDYYAE66RdVvztjvw2JD6uGjSGjCh03PyI6S95kwf4OoDRX2gqDuh_8HVcj17d_LfDSPal6MT2VX_etRxzbh4TDobj5NB6xOaom30_3_wF1B1jNg</recordid><startdate>198205</startdate><enddate>198205</enddate><creator>Valsecchi, Bruno</creator><creator>Toson, Giancarlo</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198205</creationdate><title>Mouse gallbladder emptying by egg yolk: A possible new rapid method for antispasmodic activity evaluation in vivo</title><author>Valsecchi, Bruno ; Toson, Giancarlo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c272t-92fc1724ce37f3d264ae7918ef766a5a6b146b35a8f2ecdfab0a6c6f28f51d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Antispasmodic drugs</topic><topic>Drug Evaluation, Preclinical - methods</topic><topic>effect of</topic><topic>Egg Yolk</topic><topic>Female</topic><topic>Gallbladder - drug effects</topic><topic>Gallbladder emptying</topic><topic>Injections, Intraperitoneal</topic><topic>Mice</topic><topic>Parasympatholytics - pharmacology</topic><toplevel>online_resources</toplevel><creatorcontrib>Valsecchi, Bruno</creatorcontrib><creatorcontrib>Toson, Giancarlo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmacological methods</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Valsecchi, Bruno</au><au>Toson, Giancarlo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mouse gallbladder emptying by egg yolk: A possible new rapid method for antispasmodic activity evaluation in vivo</atitle><jtitle>Journal of pharmacological methods</jtitle><addtitle>J Pharmacol Methods</addtitle><date>1982-05</date><risdate>1982</risdate><volume>7</volume><issue>3</issue><spage>193</spage><epage>195</epage><pages>193-195</pages><issn>0160-5402</issn><abstract>Gallbladder emptying was induced in female albino mice by single oral administrations of 30% lyophylized egg yolk suspension. Mice were killed 15 min later, their gallbladders removed and then weighed. Gallbladder emptying was assessed by comparing weights from control and egg yolk administered mice. The ability of the antispasmodic drugs atropine,
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| identifier | ISSN: 0160-5402 |
| ispartof | Journal of pharmacological methods, 1982-05, Vol.7 (3), p.193-195 |
| issn | 0160-5402 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Administration, Oral Animals Antispasmodic drugs Drug Evaluation, Preclinical - methods effect of Egg Yolk Female Gallbladder - drug effects Gallbladder emptying Injections, Intraperitoneal Mice Parasympatholytics - pharmacology |
| title | Mouse gallbladder emptying by egg yolk: A possible new rapid method for antispasmodic activity evaluation in vivo |
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