Depression of primate spinothalamic tract neurons by iontophoretic application of 5-hydroxytryptamine
The effects of iontophoretic applications of 5-hydroxytryptamine (5-HT) were tested upon primate spinothalamic tract neurons recorded extracellularly in the spinal cord of anesthetized monkeys. The activity of most high threshold and wide dynamic range spinothalamic tract cells was depressed. 5-HT a...
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| Veröffentlicht in: | Pain (Amsterdam) 1978-08, Vol.5 (2), p.135-142 |
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| container_title | Pain (Amsterdam) |
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| creator | Jordan, L.M. Kenshalo, D.R. Martin, R.F Haber, L.H. Willis, W.D. |
| description | The effects of iontophoretic applications of 5-hydroxytryptamine (5-HT) were tested upon primate spinothalamic tract neurons recorded extracellularly in the spinal cord of anesthetized monkeys. The activity of most high threshold and wide dynamic range spinothalamic tract cells was depressed. 5-HT also reduced the responses of the cells to glutamate pulses which by themselves had a powerful excitatory action. It is concluded that 5-HT has a depressant action upon the postsynaptic membranes of spinothalamic tract cells, although the action has a slow time course. The observations are consistent with, but by no means prove, the hypothesis that serotonergic pathways descending from the brain stem produce a postsynaptic inhibition of spinothalamic tract neurons. |
| doi_str_mv | 10.1016/0304-3959(78)90035-0 |
| format | Article |
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The activity of most high threshold and wide dynamic range spinothalamic tract cells was depressed. 5-HT also reduced the responses of the cells to glutamate pulses which by themselves had a powerful excitatory action. It is concluded that 5-HT has a depressant action upon the postsynaptic membranes of spinothalamic tract cells, although the action has a slow time course. 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The activity of most high threshold and wide dynamic range spinothalamic tract cells was depressed. 5-HT also reduced the responses of the cells to glutamate pulses which by themselves had a powerful excitatory action. It is concluded that 5-HT has a depressant action upon the postsynaptic membranes of spinothalamic tract cells, although the action has a slow time course. The observations are consistent with, but by no means prove, the hypothesis that serotonergic pathways descending from the brain stem produce a postsynaptic inhibition of spinothalamic tract neurons.</abstract><cop>United States</cop><pub>Elsevier B.V</pub><pmid>99715</pmid><doi>10.1016/0304-3959(78)90035-0</doi><tpages>8</tpages></addata></record> |
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| identifier | ISSN: 0304-3959 |
| ispartof | Pain (Amsterdam), 1978-08, Vol.5 (2), p.135-142 |
| issn | 0304-3959 1872-6623 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74177959 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Depression, Chemical Electrophysiology Evoked Potentials Glutamates - administration & dosage Glutamates - pharmacology Haplorhini Iontophoresis Macaca Pain Serotonin - administration & dosage Serotonin - pharmacology Spinothalamic Tracts - physiology Touch |
| title | Depression of primate spinothalamic tract neurons by iontophoretic application of 5-hydroxytryptamine |
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