The role of calcium in supersensitivity to the inotropic effects of norepinephrine
Experiments using electrically stimulated rabbit left atria have demonstrated that supersensitivity to the inotropic effects of norepinephrine can be induced by either chronic reserpine pretreatment or hypothermia (lowering the temperature of the bathing medium). These two experimental conditions fo...
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| Veröffentlicht in: | European journal of pharmacology 1978-08, Vol.50 (4), p.359-367 |
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| container_title | European journal of pharmacology |
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| creator | Tenner, Thomas E. McNeill, John H. Carrier, Oliver |
| description | Experiments using electrically stimulated rabbit left atria have demonstrated that supersensitivity to the inotropic effects of norepinephrine can be induced by either chronic reserpine pretreatment or hypothermia (lowering the temperature of the bathing medium). These two experimental conditions for inducing supersensitivity were not additive implying that they shared a common mechanism of action. Norepinephrine had no significant effect on the amplitude of a potentiated contraction of the rabbit atrium when the temperature was reduced from 37 to 30°C or following pretreatment with reserpine (30 or 37°C). Under these same conditions the ED
50 of norepinephrine on the normal contraction was reduced. It is concluded that both reserpine pretreatment and hypothermia induced supersensitivity to the inotropic effects of norepinephrine by enhancing the cellular store of activator calcium while not affecting the ability of norepinephrine to release activator calcium. |
| doi_str_mv | 10.1016/0014-2999(78)90141-3 |
| format | Article |
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50 of norepinephrine on the normal contraction was reduced. It is concluded that both reserpine pretreatment and hypothermia induced supersensitivity to the inotropic effects of norepinephrine by enhancing the cellular store of activator calcium while not affecting the ability of norepinephrine to release activator calcium.</description><identifier>ISSN: 0014-2999</identifier><identifier>EISSN: 1879-0712</identifier><identifier>DOI: 10.1016/0014-2999(78)90141-3</identifier><identifier>PMID: 699962</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Calcium ; Calcium - physiology ; Female ; Hypothermia- and reserpine-induced supersensitivity ; In Vitro Techniques ; Male ; Myocardial Contraction - drug effects ; Norepinephrine ; Norepinephrine - pharmacology ; Potentiated contraction ; Rabbits ; Reserpine - pharmacology ; Temperature</subject><ispartof>European journal of pharmacology, 1978-08, Vol.50 (4), p.359-367</ispartof><rights>1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-8079be5050cebca45323a908101b610d5472d0383c6f0ad10b9a89da40cfd0093</citedby><cites>FETCH-LOGICAL-c337t-8079be5050cebca45323a908101b610d5472d0383c6f0ad10b9a89da40cfd0093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0014299978901413$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/699962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tenner, Thomas E.</creatorcontrib><creatorcontrib>McNeill, John H.</creatorcontrib><creatorcontrib>Carrier, Oliver</creatorcontrib><title>The role of calcium in supersensitivity to the inotropic effects of norepinephrine</title><title>European journal of pharmacology</title><addtitle>Eur J Pharmacol</addtitle><description>Experiments using electrically stimulated rabbit left atria have demonstrated that supersensitivity to the inotropic effects of norepinephrine can be induced by either chronic reserpine pretreatment or hypothermia (lowering the temperature of the bathing medium). These two experimental conditions for inducing supersensitivity were not additive implying that they shared a common mechanism of action. Norepinephrine had no significant effect on the amplitude of a potentiated contraction of the rabbit atrium when the temperature was reduced from 37 to 30°C or following pretreatment with reserpine (30 or 37°C). Under these same conditions the ED
50 of norepinephrine on the normal contraction was reduced. It is concluded that both reserpine pretreatment and hypothermia induced supersensitivity to the inotropic effects of norepinephrine by enhancing the cellular store of activator calcium while not affecting the ability of norepinephrine to release activator calcium.</description><subject>Animals</subject><subject>Calcium</subject><subject>Calcium - physiology</subject><subject>Female</subject><subject>Hypothermia- and reserpine-induced supersensitivity</subject><subject>In Vitro Techniques</subject><subject>Male</subject><subject>Myocardial Contraction - drug effects</subject><subject>Norepinephrine</subject><subject>Norepinephrine - pharmacology</subject><subject>Potentiated contraction</subject><subject>Rabbits</subject><subject>Reserpine - pharmacology</subject><subject>Temperature</subject><issn>0014-2999</issn><issn>1879-0712</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LxDAQhoP4ta7-gz30JHqoTpq2SS6CLH7BgiDrOaTplI10m5q0C_vvzbqLRy8zzMz7vjAPITMKdxRoeQ9A8zSTUt5wcSvjQFN2RCZUcJkCp9kxmfxJzslFCF8AUMisOCOnZdyV2YR8LFeYeNdi4prE6NbYcZ3YLgljjz5gF-xgN3bYJoNLhii1nRu8661JsGnQDGHn65zH3nbYr3ysl-Sk0W3Aq0Ofks_np-X8NV28v7zNHxepYYwPqQAuKyygAIOV0XnBMqYliPhaVVKoi5xnNTDBTNmArilUUgtZ6xxMUwNINiXX-9zeu-8Rw6DWNhhsW92hG4PiOeWlKEQU5nuh8S4Ej43qvV1rv1UU1I6k2mFSO0yKC_VLUrFomx3yx2qN9Z9pjy6eH_ZnjD9uLHoVjMXOYG19BKNqZ__P_wHl2oKs</recordid><startdate>19780815</startdate><enddate>19780815</enddate><creator>Tenner, Thomas E.</creator><creator>McNeill, John H.</creator><creator>Carrier, Oliver</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19780815</creationdate><title>The role of calcium in supersensitivity to the inotropic effects of norepinephrine</title><author>Tenner, Thomas E. ; McNeill, John H. ; Carrier, Oliver</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-8079be5050cebca45323a908101b610d5472d0383c6f0ad10b9a89da40cfd0093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Calcium</topic><topic>Calcium - physiology</topic><topic>Female</topic><topic>Hypothermia- and reserpine-induced supersensitivity</topic><topic>In Vitro Techniques</topic><topic>Male</topic><topic>Myocardial Contraction - drug effects</topic><topic>Norepinephrine</topic><topic>Norepinephrine - pharmacology</topic><topic>Potentiated contraction</topic><topic>Rabbits</topic><topic>Reserpine - pharmacology</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tenner, Thomas E.</creatorcontrib><creatorcontrib>McNeill, John H.</creatorcontrib><creatorcontrib>Carrier, Oliver</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tenner, Thomas E.</au><au>McNeill, John H.</au><au>Carrier, Oliver</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of calcium in supersensitivity to the inotropic effects of norepinephrine</atitle><jtitle>European journal of pharmacology</jtitle><addtitle>Eur J Pharmacol</addtitle><date>1978-08-15</date><risdate>1978</risdate><volume>50</volume><issue>4</issue><spage>359</spage><epage>367</epage><pages>359-367</pages><issn>0014-2999</issn><eissn>1879-0712</eissn><abstract>Experiments using electrically stimulated rabbit left atria have demonstrated that supersensitivity to the inotropic effects of norepinephrine can be induced by either chronic reserpine pretreatment or hypothermia (lowering the temperature of the bathing medium). These two experimental conditions for inducing supersensitivity were not additive implying that they shared a common mechanism of action. Norepinephrine had no significant effect on the amplitude of a potentiated contraction of the rabbit atrium when the temperature was reduced from 37 to 30°C or following pretreatment with reserpine (30 or 37°C). Under these same conditions the ED
50 of norepinephrine on the normal contraction was reduced. It is concluded that both reserpine pretreatment and hypothermia induced supersensitivity to the inotropic effects of norepinephrine by enhancing the cellular store of activator calcium while not affecting the ability of norepinephrine to release activator calcium.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>699962</pmid><doi>10.1016/0014-2999(78)90141-3</doi><tpages>9</tpages></addata></record> |
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| ispartof | European journal of pharmacology, 1978-08, Vol.50 (4), p.359-367 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Calcium Calcium - physiology Female Hypothermia- and reserpine-induced supersensitivity In Vitro Techniques Male Myocardial Contraction - drug effects Norepinephrine Norepinephrine - pharmacology Potentiated contraction Rabbits Reserpine - pharmacology Temperature |
| title | The role of calcium in supersensitivity to the inotropic effects of norepinephrine |
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