THE EFFECT OF BROMOCRIPTINE ON RAT STRIATAL ADENYLATE CYCLASE AND RAT BRAIN MONOAMINE METABOLISM
In slices and homogenate from rat brain striatum bromocriptine in marked contrast to DA. NA and apomorphine. had no stimulatory effect on adenylate cyclase activity, but antagonised the stimulatory effects of both NA and DA. Bromocriptine (10 mg/kg s.c.) decreased the turnover of DA in striatum and...
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| Veröffentlicht in: | Journal of neurochemistry 1978-11, Vol.31 (5), p.1163-1172 |
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| container_end_page | 1172 |
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| container_issue | 5 |
| container_start_page | 1163 |
| container_title | Journal of neurochemistry |
| container_volume | 31 |
| creator | Markstein, R. Herrling, P. L. Asper, H. R. Buurki. H. Ruch, W. |
| description | In slices and homogenate from rat brain striatum bromocriptine in marked contrast to DA. NA and apomorphine. had no stimulatory effect on adenylate cyclase activity, but antagonised the stimulatory effects of both NA and DA.
Bromocriptine (10 mg/kg s.c.) decreased the turnover of DA in striatum and limbic structures 3h after drug administration. However, an increase in the turnover of NA in the brain stem and that of 5‐HT in the cortex was observed 4h following treatment with bromocriptine. Possible modes of action of bromocriptine are discussed. |
| doi_str_mv | 10.1111/j.1471-4159.1978.tb06240.x |
| format | Article |
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Bromocriptine (10 mg/kg s.c.) decreased the turnover of DA in striatum and limbic structures 3h after drug administration. However, an increase in the turnover of NA in the brain stem and that of 5‐HT in the cortex was observed 4h following treatment with bromocriptine. Possible modes of action of bromocriptine are discussed.</description><identifier>ISSN: 0022-3042</identifier><identifier>EISSN: 1471-4159</identifier><identifier>DOI: 10.1111/j.1471-4159.1978.tb06240.x</identifier><identifier>PMID: 702165</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Adenylyl Cyclases - metabolism ; Animals ; Biogenic Amines - metabolism ; Brain - drug effects ; Brain - metabolism ; Bromocriptine - pharmacology ; Corpus Striatum - drug effects ; Corpus Striatum - enzymology ; Dopamine - pharmacology ; Male ; Norepinephrine - pharmacology ; Rats ; Tissue Distribution</subject><ispartof>Journal of neurochemistry, 1978-11, Vol.31 (5), p.1163-1172</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2843-c0f842edb13ce36fa24ca2b2ca95ec76e5cdc3f4a9b27c231461a7a8fc2d68243</citedby><cites>FETCH-LOGICAL-c2843-c0f842edb13ce36fa24ca2b2ca95ec76e5cdc3f4a9b27c231461a7a8fc2d68243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1471-4159.1978.tb06240.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1471-4159.1978.tb06240.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/702165$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Markstein, R.</creatorcontrib><creatorcontrib>Herrling, P. L.</creatorcontrib><creatorcontrib>Asper, H. R. Buurki. H.</creatorcontrib><creatorcontrib>Ruch, W.</creatorcontrib><title>THE EFFECT OF BROMOCRIPTINE ON RAT STRIATAL ADENYLATE CYCLASE AND RAT BRAIN MONOAMINE METABOLISM</title><title>Journal of neurochemistry</title><addtitle>J Neurochem</addtitle><description>In slices and homogenate from rat brain striatum bromocriptine in marked contrast to DA. NA and apomorphine. had no stimulatory effect on adenylate cyclase activity, but antagonised the stimulatory effects of both NA and DA.
Bromocriptine (10 mg/kg s.c.) decreased the turnover of DA in striatum and limbic structures 3h after drug administration. However, an increase in the turnover of NA in the brain stem and that of 5‐HT in the cortex was observed 4h following treatment with bromocriptine. Possible modes of action of bromocriptine are discussed.</description><subject>Adenylyl Cyclases - metabolism</subject><subject>Animals</subject><subject>Biogenic Amines - metabolism</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Bromocriptine - pharmacology</subject><subject>Corpus Striatum - drug effects</subject><subject>Corpus Striatum - enzymology</subject><subject>Dopamine - pharmacology</subject><subject>Male</subject><subject>Norepinephrine - pharmacology</subject><subject>Rats</subject><subject>Tissue Distribution</subject><issn>0022-3042</issn><issn>1471-4159</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkMtO4zAUhi3EAJ3OvAELi8XsEnxLnLBBbnAhKJdR6lmwMo7rSK1aWhKqgbcnoVX3nM1Z_Jej8wFwhZGP-7le-phx7DEcxD6OeeS_1SgkDPnvJ2B0lE7BCCFCPIoYuQA_u26JEA5ZiM_BGUcEh8EIPKsHCeV0KhMFyymcVGVeJlX6V6WFhGUBK6HgTFWpUCKD4k4WT5lQEiZPSSZmEori7ssyqURawLwsSpEPyVwqMSmzdJb_Aj8as-rc78Meg39TqZIHLyvv00RkniURo55FTcSIm9eYWkfDxhBmDamJNXHgLA9dYOeWNszENeGWUNy_YbiJGkvmYUQYHYM_-95tu3ndue5NrxeddauVeXGbXac5w5zyOOiNN3ujbTdd17pGb9vF2rQfGiM90NVLPSDUA0I90NUHuvq9D18eruzqtZsfo3ucvXy7l_8vVu7jG8X6sUgwDin9BIIvgcA</recordid><startdate>197811</startdate><enddate>197811</enddate><creator>Markstein, R.</creator><creator>Herrling, P. L.</creator><creator>Asper, H. R. Buurki. H.</creator><creator>Ruch, W.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197811</creationdate><title>THE EFFECT OF BROMOCRIPTINE ON RAT STRIATAL ADENYLATE CYCLASE AND RAT BRAIN MONOAMINE METABOLISM</title><author>Markstein, R. ; Herrling, P. L. ; Asper, H. R. Buurki. H. ; Ruch, W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2843-c0f842edb13ce36fa24ca2b2ca95ec76e5cdc3f4a9b27c231461a7a8fc2d68243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adenylyl Cyclases - metabolism</topic><topic>Animals</topic><topic>Biogenic Amines - metabolism</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Bromocriptine - pharmacology</topic><topic>Corpus Striatum - drug effects</topic><topic>Corpus Striatum - enzymology</topic><topic>Dopamine - pharmacology</topic><topic>Male</topic><topic>Norepinephrine - pharmacology</topic><topic>Rats</topic><topic>Tissue Distribution</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Markstein, R.</creatorcontrib><creatorcontrib>Herrling, P. L.</creatorcontrib><creatorcontrib>Asper, H. R. Buurki. H.</creatorcontrib><creatorcontrib>Ruch, W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of neurochemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Markstein, R.</au><au>Herrling, P. L.</au><au>Asper, H. R. Buurki. H.</au><au>Ruch, W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THE EFFECT OF BROMOCRIPTINE ON RAT STRIATAL ADENYLATE CYCLASE AND RAT BRAIN MONOAMINE METABOLISM</atitle><jtitle>Journal of neurochemistry</jtitle><addtitle>J Neurochem</addtitle><date>1978-11</date><risdate>1978</risdate><volume>31</volume><issue>5</issue><spage>1163</spage><epage>1172</epage><pages>1163-1172</pages><issn>0022-3042</issn><eissn>1471-4159</eissn><abstract>In slices and homogenate from rat brain striatum bromocriptine in marked contrast to DA. NA and apomorphine. had no stimulatory effect on adenylate cyclase activity, but antagonised the stimulatory effects of both NA and DA.
Bromocriptine (10 mg/kg s.c.) decreased the turnover of DA in striatum and limbic structures 3h after drug administration. However, an increase in the turnover of NA in the brain stem and that of 5‐HT in the cortex was observed 4h following treatment with bromocriptine. Possible modes of action of bromocriptine are discussed.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>702165</pmid><doi>10.1111/j.1471-4159.1978.tb06240.x</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of neurochemistry, 1978-11, Vol.31 (5), p.1163-1172 |
| issn | 0022-3042 1471-4159 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adenylyl Cyclases - metabolism Animals Biogenic Amines - metabolism Brain - drug effects Brain - metabolism Bromocriptine - pharmacology Corpus Striatum - drug effects Corpus Striatum - enzymology Dopamine - pharmacology Male Norepinephrine - pharmacology Rats Tissue Distribution |
| title | THE EFFECT OF BROMOCRIPTINE ON RAT STRIATAL ADENYLATE CYCLASE AND RAT BRAIN MONOAMINE METABOLISM |
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