Methylthioadenosine nucleoside phosphorylase deficiency in methylthio-dependent cancer cells

The cleavage of the methylthio group from methylthioadenosine is shown to involve two enzymes, a nucleosidase which catalyses the phosphorolytic cleavage of methylthioadenosine to yield adenine and 5-methylthioribose-1-phosphate and an enzyme which uses the latter compound as substrate and catalyses...

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Veröffentlicht in:	Biochemical and biophysical research communications 1978-07, Vol.83 (1), p.27-35
1. Verfasser:	Toohey, John I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - analogs & derivatives Adenosine Deaminase - metabolism Arsenates - pharmacology Cell Line Hydrolases Kinetics Pentosyltransferases - deficiency Phosphates - pharmacology Purine-Nucleoside Phosphorylase - deficiency Purine-Nucleoside Phosphorylase - metabolism Ribosemonophosphates Thionucleosides Thionucleotides
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