Early atherosclerotic lesions in rat aorta. Effect of cholesterol feeding and immunization
Germ-free and conventional rats were fed cholesterol or normal pellets and part of both groups were immunized repeatedly with horseradish peroxidase (HRP). Four days after the last injections all the rats were killed, aortas removed and prepared for immunocytology and chemical analysis. Free peroxid...
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| Veröffentlicht in: | Research in experimental medicine 1978-10, Vol.173 (3), p.251-259 |
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| container_title | Research in experimental medicine |
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| creator | Horsch, A K Kuhlmann, W D Bleyl, U Salomon, J C |
| description | Germ-free and conventional rats were fed cholesterol or normal pellets and part of both groups were immunized repeatedly with horseradish peroxidase (HRP). Four days after the last injections all the rats were killed, aortas removed and prepared for immunocytology and chemical analysis. Free peroxidase was not detected in the arterial wall and in all immunized rats only faint staining of free anti-HRP antibodies occurred in the intima. In contrast there was a consistent deposition of HRP-anti-HRP antibody complexes in the inner two thirds of the arterial wall in all HRP-immunized animals. Immunization and cholesterol feeding increased the cholesterol content of the aorta and produced early lesions, whereas cholesterol feeding or immunization alone was less effective. |
| doi_str_mv | 10.1007/BF01851497 |
| format | Article |
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Immunization and cholesterol feeding increased the cholesterol content of the aorta and produced early lesions, whereas cholesterol feeding or immunization alone was less effective.</description><identifier>ISSN: 0300-9130</identifier><identifier>EISSN: 1433-8580</identifier><identifier>DOI: 10.1007/BF01851497</identifier><identifier>PMID: 725328</identifier><language>eng</language><publisher>Germany</publisher><subject>Animals ; Antigen-Antibody Complex ; Aorta - metabolism ; Aorta - pathology ; Arteriosclerosis - etiology ; Arteriosclerosis - immunology ; Arteriosclerosis - pathology ; Cholesterol, Dietary - adverse effects ; Endothelium - pathology ; Germ-Free Life ; Immunization ; Lipid Metabolism ; Lipids - blood ; Rats</subject><ispartof>Research in experimental medicine, 1978-10, Vol.173 (3), p.251-259</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c240t-7fb522caf1c791d94ec0701c5b44e22dc813237b919a624a2cee34438b5281023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/725328$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Horsch, A K</creatorcontrib><creatorcontrib>Kuhlmann, W D</creatorcontrib><creatorcontrib>Bleyl, U</creatorcontrib><creatorcontrib>Salomon, J C</creatorcontrib><title>Early atherosclerotic lesions in rat aorta. 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Immunization and cholesterol feeding increased the cholesterol content of the aorta and produced early lesions, whereas cholesterol feeding or immunization alone was less effective.</description><subject>Animals</subject><subject>Antigen-Antibody Complex</subject><subject>Aorta - metabolism</subject><subject>Aorta - pathology</subject><subject>Arteriosclerosis - etiology</subject><subject>Arteriosclerosis - immunology</subject><subject>Arteriosclerosis - pathology</subject><subject>Cholesterol, Dietary - adverse effects</subject><subject>Endothelium - pathology</subject><subject>Germ-Free Life</subject><subject>Immunization</subject><subject>Lipid Metabolism</subject><subject>Lipids - blood</subject><subject>Rats</subject><issn>0300-9130</issn><issn>1433-8580</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkD1PwzAQhi3EVykszAyeGJBS7mwnTkaoWkCqxAILS-Q6NjXKR7Gdofx6jIpguVue99XdQ8glwgwB5O39ErDMUVTygExQcJ6VeQmHZAIcIKuQwyk5C-EDAGUh8YQcS5ZzVk7I20L5dkdV3Bg_BN2mGZ2mrQlu6AN1PfUqUjX4qGZ0Ya3RkQ6W6s2QkJjollpjGte_U9U31HXd2LsvFVP6nBxZ1QZz8bun5HW5eJk_Zqvnh6f53SrTTEDMpF3njGllUcsKm0oYDRJQ52shDGONLpEzLtcVVqpgQjFtDBeClylWIjA-Jdf73q0fPsd0Vd25oE3bqt4MY6ilQAlFUSTwZg_q9GrwxtZb7zrldzVC_eOx_veY4Kvf1nHdmeYP3Yvj37W9bM0</recordid><startdate>197810</startdate><enddate>197810</enddate><creator>Horsch, A K</creator><creator>Kuhlmann, W D</creator><creator>Bleyl, U</creator><creator>Salomon, J C</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197810</creationdate><title>Early atherosclerotic lesions in rat aorta. 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Effect of cholesterol feeding and immunization</atitle><jtitle>Research in experimental medicine</jtitle><addtitle>Res Exp Med (Berl)</addtitle><date>1978-10</date><risdate>1978</risdate><volume>173</volume><issue>3</issue><spage>251</spage><epage>259</epage><pages>251-259</pages><issn>0300-9130</issn><eissn>1433-8580</eissn><abstract>Germ-free and conventional rats were fed cholesterol or normal pellets and part of both groups were immunized repeatedly with horseradish peroxidase (HRP). Four days after the last injections all the rats were killed, aortas removed and prepared for immunocytology and chemical analysis. Free peroxidase was not detected in the arterial wall and in all immunized rats only faint staining of free anti-HRP antibodies occurred in the intima. In contrast there was a consistent deposition of HRP-anti-HRP antibody complexes in the inner two thirds of the arterial wall in all HRP-immunized animals. Immunization and cholesterol feeding increased the cholesterol content of the aorta and produced early lesions, whereas cholesterol feeding or immunization alone was less effective.</abstract><cop>Germany</cop><pmid>725328</pmid><doi>10.1007/BF01851497</doi><tpages>9</tpages></addata></record> |
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| ispartof | Research in experimental medicine, 1978-10, Vol.173 (3), p.251-259 |
| issn | 0300-9130 1433-8580 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Antigen-Antibody Complex Aorta - metabolism Aorta - pathology Arteriosclerosis - etiology Arteriosclerosis - immunology Arteriosclerosis - pathology Cholesterol, Dietary - adverse effects Endothelium - pathology Germ-Free Life Immunization Lipid Metabolism Lipids - blood Rats |
| title | Early atherosclerotic lesions in rat aorta. Effect of cholesterol feeding and immunization |
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