Interaction of nitrofurantoin with diphenylhydantoin

Left-sided motor seizures in a patient with an operated brain tumor were controlled with 300 mg/d DPH. The introduction of antimicrobial therapy with nitrofurantoin caused a fall of serum DPH levels and the recurrence of seizures, at the same time serum gammaGT values were increased. These changes w...

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Veröffentlicht in:	Journal of neurology 1978-08, Vol.218 (4), p.297-301
Hauptverfasser:	Heipertz, R, Pilz, H
Format:	Artikel
Sprache:	eng
Schlagworte:	Humans Male Middle Aged Nitrofurantoin - administration & dosage Phenytoin - administration & dosage Phenytoin - antagonists & inhibitors Seizures - therapy
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description	Left-sided motor seizures in a patient with an operated brain tumor were controlled with 300 mg/d DPH. The introduction of antimicrobial therapy with nitrofurantoin caused a fall of serum DPH levels and the recurrence of seizures, at the same time serum gammaGT values were increased. These changes were reversible after nitrofurantoin treatment was terminated. Both increased DPH metabolism or impaired absorption could be responsible for this effect. The concomittant increase of gammaGT could be interpreted as indirect evidence of hepatic enzyme induction with increased metabolism of DPH. It is important to note the possibility of such interaction so that better anticonvulsant control can be achieved.
doi_str_mv	10.1007/BF00312886
format	Article
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The introduction of antimicrobial therapy with nitrofurantoin caused a fall of serum DPH levels and the recurrence of seizures, at the same time serum gammaGT values were increased. These changes were reversible after nitrofurantoin treatment was terminated. Both increased DPH metabolism or impaired absorption could be responsible for this effect. The concomittant increase of gammaGT could be interpreted as indirect evidence of hepatic enzyme induction with increased metabolism of DPH. 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source	MEDLINE; Springer Nature - Complete Springer Journals
subjects	Humans Male Middle Aged Nitrofurantoin - administration & dosage Phenytoin - administration & dosage Phenytoin - antagonists & inhibitors Seizures - therapy
title	Interaction of nitrofurantoin with diphenylhydantoin
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