Studies on the Mechanism of the Acute Antihypertensive and Vasodilator Actions of Several β-Adrenoceptor Antagonists

SUMMARYSeveral new β-adrenoceptor antagonists (sulfinalol, MK 761, and prizidilol) have been reported to possess direct vasodilator activity in addition to blocking β-receptors. The mechanism of the hypotensive and vasodilator actions of these agents was examined and compared to that of pindolol and...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 1982-09, Vol.4 (5), p.749-758
Hauptverfasser:	Sybertz, Edmund J, Baum, Thomas, Pula, Kathryn K, Nelson, Steven, Eynon, Emma, Sabin, Crawford
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic beta-Antagonists - pharmacology Animals Antihypertensive Agents - pharmacology Blood Flow Velocity Blood Pressure - drug effects Dogs Female Heart Rate - drug effects Hemodynamics - drug effects Hypertension - drug therapy Male Pyridazines - pharmacology Pyridines - pharmacology Rats Rats, Inbred Strains Vasodilator Agents - pharmacology
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