Neurotropic and Psychotropic Agents. VI. 1-Alkoxymethyl-1, 3-dihydro-2H-1, 4-benzodiazepin-2-ones
1-Alkoxymethyl-1, 3-dihydro-2H-1, 4-benzodiazepin-2-ones (II) were prepared by two methods : one was direct alkylation of 1, 4-benzodiazepin-2-ones (I) with alkoxymethyl chlorides and the other was via 2-[N-(alkoxymethyl) phthalimidoacetamido] benzophenones (IV) which were prepared from the correspo...
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Veröffentlicht in: | Chemical & pharmaceutical bulletin 1982/04/25, Vol.30(4), pp.1477-1480 |
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creator | KISHIMOTO, TEIJI MATSUO, MASAAKI UEDA, IKUO |
description | 1-Alkoxymethyl-1, 3-dihydro-2H-1, 4-benzodiazepin-2-ones (II) were prepared by two methods : one was direct alkylation of 1, 4-benzodiazepin-2-ones (I) with alkoxymethyl chlorides and the other was via 2-[N-(alkoxymethyl) phthalimidoacetamido] benzophenones (IV) which were prepared from the corresponding 2-(phthalimidoactamido) benzophenones (III) and alkoxymethyl chlorides. Certain compounds prepared had comparable activity to diazepam and chlorodiazepoxide in taming and anticonvulsant tests in mice. |
doi_str_mv | 10.1248/cpb.30.1477 |
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Certain compounds prepared had comparable activity to diazepam and chlorodiazepoxide in taming and anticonvulsant tests in mice.</description><identifier>ISSN: 0009-2363</identifier><identifier>EISSN: 1347-5223</identifier><identifier>DOI: 10.1248/cpb.30.1477</identifier><identifier>PMID: 7201889</identifier><language>eng</language><publisher>Japan: The Pharmaceutical Society of Japan</publisher><subject>Aggression - drug effects ; Animals ; anticonvulsant effect in mice ; Anticonvulsants - chemical synthesis ; Benzodiazepinones - chemical synthesis ; Benzodiazepinones - pharmacology ; Humans ; Mice ; Psychotropic Drugs - chemical synthesis</subject><ispartof>Chemical and Pharmaceutical Bulletin, 1982/04/25, Vol.30(4), pp.1477-1480</ispartof><rights>The Pharmaceutical Society of Japan</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4647-e897e9760f4f5c7a843272043872652a83218efc47e399d6e7df209da35cd2213</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,1877,4010,27900,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7201889$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>KISHIMOTO, TEIJI</creatorcontrib><creatorcontrib>MATSUO, MASAAKI</creatorcontrib><creatorcontrib>UEDA, IKUO</creatorcontrib><title>Neurotropic and Psychotropic Agents. 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Certain compounds prepared had comparable activity to diazepam and chlorodiazepoxide in taming and anticonvulsant tests in mice.</description><subject>Aggression - drug effects</subject><subject>Animals</subject><subject>anticonvulsant effect in mice</subject><subject>Anticonvulsants - chemical synthesis</subject><subject>Benzodiazepinones - chemical synthesis</subject><subject>Benzodiazepinones - pharmacology</subject><subject>Humans</subject><subject>Mice</subject><subject>Psychotropic Drugs - chemical synthesis</subject><issn>0009-2363</issn><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkDtPwzAUhS0EgvKYmJEysYCLX4mdsSpPqQIGYI1c-4YG0jjYqUT663HUAst9naNPVwehU0rGlAl1Zdr5mMdZSLmDRpQLiVPG-C4aEUJyzHjGD9BhCB-EsJRIvo_2JSNUqXyE9COsvOu8ayuT6MYmz6E3i9_D5B2aLoyTt4dxQvGk_nTf_RK6RV9jeplwbKtFb73D7H7YBZ5Ds3a20mtoqwYz7BoIx2iv1HWAk20_Qq-3Ny_Tezx7unuYTmbYiCx-DCqXkMuMlKJMjdRKcBa_FFxJlqVMK86ogtIICTzPbQbSlozkVvPUWMYoP0LnG27r3dcKQlcsq2CgrnUDbhUKKWhGKVPReLExGu9C8FAWra-W2vcFJcUQaBEDLXicY6DRfbbFruZLsH_ebYJRv97oH6HT7_Cna99VpoaBRfNUDTyxKQP2X15oX0DDfwAXrIYj</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>KISHIMOTO, TEIJI</creator><creator>MATSUO, MASAAKI</creator><creator>UEDA, IKUO</creator><general>The Pharmaceutical Society of Japan</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1982</creationdate><title>Neurotropic and Psychotropic Agents. 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VI. 1-Alkoxymethyl-1, 3-dihydro-2H-1, 4-benzodiazepin-2-ones</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem. Pharm. Bull.</addtitle><date>1982</date><risdate>1982</risdate><volume>30</volume><issue>4</issue><spage>1477</spage><epage>1480</epage><pages>1477-1480</pages><issn>0009-2363</issn><eissn>1347-5223</eissn><abstract>1-Alkoxymethyl-1, 3-dihydro-2H-1, 4-benzodiazepin-2-ones (II) were prepared by two methods : one was direct alkylation of 1, 4-benzodiazepin-2-ones (I) with alkoxymethyl chlorides and the other was via 2-[N-(alkoxymethyl) phthalimidoacetamido] benzophenones (IV) which were prepared from the corresponding 2-(phthalimidoactamido) benzophenones (III) and alkoxymethyl chlorides. 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source | J-STAGE Free; MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry |
subjects | Aggression - drug effects Animals anticonvulsant effect in mice Anticonvulsants - chemical synthesis Benzodiazepinones - chemical synthesis Benzodiazepinones - pharmacology Humans Mice Psychotropic Drugs - chemical synthesis |
title | Neurotropic and Psychotropic Agents. VI. 1-Alkoxymethyl-1, 3-dihydro-2H-1, 4-benzodiazepin-2-ones |
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