Changes in a somatomedin-like factor and immunoassayable growth hormone during growth of normal and dwarf pullets and cockerels
Serum somatomedin-like factor (Sm) and growth hormone (GH) were determined in normal and dwarf Leghorn chickens during the growth period from 7 to 30 weeks of age. The serum Sm activity was reduced with the advance in age, although there was no distinct decrease in serum GH concentrations by strain...
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Veröffentlicht in: | Poultry science 1982-04, Vol.61 (4), p.777-784 |
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creator | Hoshino, S Wakita, M Suzuki, M Yamamoto, K |
description | Serum somatomedin-like factor (Sm) and growth hormone (GH) were determined in normal and dwarf Leghorn chickens during the growth period from 7 to 30 weeks of age. The serum Sm activity was reduced with the advance in age, although there was no distinct decrease in serum GH concentrations by strain or sex. In both strains, serum from male showed significantly greater Sm activity than that from females. In contrast, the GH level in male serum was lower than that in females. In dwarf chickens, serum GH levels were comparable to those in normal chickens but Sm activity was extremely low, from 1% to 33% of the normal male serum. The serum level of inorganic sulfate, butanol extractable inhibitor, and free fatty acids in the dwarf bird was in the normal range, indicating that the low Sm activity was not attributable to a change in these factors. The response to Sm of cartilages from both dwarf and normal chickens was similar. The results indicate that the cause of the dwarfism is not poor-response of cartilage to Sm, but mainly low Sm activity during the period of growth, suggesting a possible Laron-type dwarfism in chicken. |
doi_str_mv | 10.3382/ps.0610777 |
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The serum Sm activity was reduced with the advance in age, although there was no distinct decrease in serum GH concentrations by strain or sex. In both strains, serum from male showed significantly greater Sm activity than that from females. In contrast, the GH level in male serum was lower than that in females. In dwarf chickens, serum GH levels were comparable to those in normal chickens but Sm activity was extremely low, from 1% to 33% of the normal male serum. The serum level of inorganic sulfate, butanol extractable inhibitor, and free fatty acids in the dwarf bird was in the normal range, indicating that the low Sm activity was not attributable to a change in these factors. The response to Sm of cartilages from both dwarf and normal chickens was similar. The results indicate that the cause of the dwarfism is not poor-response of cartilage to Sm, but mainly low Sm activity during the period of growth, suggesting a possible Laron-type dwarfism in chicken.</description><identifier>ISSN: 0032-5791</identifier><identifier>DOI: 10.3382/ps.0610777</identifier><identifier>PMID: 7100063</identifier><language>eng</language><publisher>England</publisher><subject>Animals ; Cartilage - metabolism ; Chickens - growth & development ; Dwarfism - physiopathology ; Dwarfism - veterinary ; Fatty Acids, Nonesterified - blood ; Female ; Growth Hormone - blood ; Male ; Poultry Diseases - physiopathology ; Sex Factors ; Somatomedins - blood ; Sulfates - metabolism</subject><ispartof>Poultry science, 1982-04, Vol.61 (4), p.777-784</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c384t-f77ec77a5c7f29b6db189c11eabc58b4fde3453b0a3f336083038ed9b3d0ad803</citedby><cites>FETCH-LOGICAL-c384t-f77ec77a5c7f29b6db189c11eabc58b4fde3453b0a3f336083038ed9b3d0ad803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7100063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hoshino, S</creatorcontrib><creatorcontrib>Wakita, M</creatorcontrib><creatorcontrib>Suzuki, M</creatorcontrib><creatorcontrib>Yamamoto, K</creatorcontrib><title>Changes in a somatomedin-like factor and immunoassayable growth hormone during growth of normal and dwarf pullets and cockerels</title><title>Poultry science</title><addtitle>Poult Sci</addtitle><description>Serum somatomedin-like factor (Sm) and growth hormone (GH) were determined in normal and dwarf Leghorn chickens during the growth period from 7 to 30 weeks of age. The serum Sm activity was reduced with the advance in age, although there was no distinct decrease in serum GH concentrations by strain or sex. In both strains, serum from male showed significantly greater Sm activity than that from females. In contrast, the GH level in male serum was lower than that in females. In dwarf chickens, serum GH levels were comparable to those in normal chickens but Sm activity was extremely low, from 1% to 33% of the normal male serum. The serum level of inorganic sulfate, butanol extractable inhibitor, and free fatty acids in the dwarf bird was in the normal range, indicating that the low Sm activity was not attributable to a change in these factors. The response to Sm of cartilages from both dwarf and normal chickens was similar. The results indicate that the cause of the dwarfism is not poor-response of cartilage to Sm, but mainly low Sm activity during the period of growth, suggesting a possible Laron-type dwarfism in chicken.</description><subject>Animals</subject><subject>Cartilage - metabolism</subject><subject>Chickens - growth & development</subject><subject>Dwarfism - physiopathology</subject><subject>Dwarfism - veterinary</subject><subject>Fatty Acids, Nonesterified - blood</subject><subject>Female</subject><subject>Growth Hormone - blood</subject><subject>Male</subject><subject>Poultry Diseases - physiopathology</subject><subject>Sex Factors</subject><subject>Somatomedins - blood</subject><subject>Sulfates - metabolism</subject><issn>0032-5791</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kD1PwzAURT2ASiks7EieGJBS7DiJkxFVfElILDBHL_ZzG-rYwU5UdeKvU9rC9KT7zr3DIeSKs7kQZXrXxzkrOJNSnpApYyJNclnxM3Ie4ydjKS8KOSETyRljhZiS78UK3BIjbR0FGn0Hg-9Qty6x7RqpATX4QMFp2nbd6DzECFtoLNJl8JthRVc-dN4h1WNo3fIv9Ya63QPsvqo3EAztR2txiPtEebXGgDZekFMDNuLl8c7Ix-PD--I5eX17elncvyZKlNmQGClRSQm5kiatmkI3vKwU5wiNyssmMxpFlouGgTBCFKwUTJSoq0ZoBrpkYkZuDrt98F8jxqHu2qjQWnDox1jLjOdVkZc78PYAquBjDGjqPrQdhG3NWf1ruO5jfTS8g6-Pq2Ozs_aPHvWKH542e3g</recordid><startdate>198204</startdate><enddate>198204</enddate><creator>Hoshino, S</creator><creator>Wakita, M</creator><creator>Suzuki, M</creator><creator>Yamamoto, K</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198204</creationdate><title>Changes in a somatomedin-like factor and immunoassayable growth hormone during growth of normal and dwarf pullets and cockerels</title><author>Hoshino, S ; Wakita, M ; Suzuki, M ; Yamamoto, K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c384t-f77ec77a5c7f29b6db189c11eabc58b4fde3453b0a3f336083038ed9b3d0ad803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Cartilage - metabolism</topic><topic>Chickens - growth & development</topic><topic>Dwarfism - physiopathology</topic><topic>Dwarfism - veterinary</topic><topic>Fatty Acids, Nonesterified - blood</topic><topic>Female</topic><topic>Growth Hormone - blood</topic><topic>Male</topic><topic>Poultry Diseases - physiopathology</topic><topic>Sex Factors</topic><topic>Somatomedins - blood</topic><topic>Sulfates - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hoshino, S</creatorcontrib><creatorcontrib>Wakita, M</creatorcontrib><creatorcontrib>Suzuki, M</creatorcontrib><creatorcontrib>Yamamoto, K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Poultry science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hoshino, S</au><au>Wakita, M</au><au>Suzuki, M</au><au>Yamamoto, K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in a somatomedin-like factor and immunoassayable growth hormone during growth of normal and dwarf pullets and cockerels</atitle><jtitle>Poultry science</jtitle><addtitle>Poult Sci</addtitle><date>1982-04</date><risdate>1982</risdate><volume>61</volume><issue>4</issue><spage>777</spage><epage>784</epage><pages>777-784</pages><issn>0032-5791</issn><abstract>Serum somatomedin-like factor (Sm) and growth hormone (GH) were determined in normal and dwarf Leghorn chickens during the growth period from 7 to 30 weeks of age. The serum Sm activity was reduced with the advance in age, although there was no distinct decrease in serum GH concentrations by strain or sex. In both strains, serum from male showed significantly greater Sm activity than that from females. In contrast, the GH level in male serum was lower than that in females. In dwarf chickens, serum GH levels were comparable to those in normal chickens but Sm activity was extremely low, from 1% to 33% of the normal male serum. The serum level of inorganic sulfate, butanol extractable inhibitor, and free fatty acids in the dwarf bird was in the normal range, indicating that the low Sm activity was not attributable to a change in these factors. The response to Sm of cartilages from both dwarf and normal chickens was similar. The results indicate that the cause of the dwarfism is not poor-response of cartilage to Sm, but mainly low Sm activity during the period of growth, suggesting a possible Laron-type dwarfism in chicken.</abstract><cop>England</cop><pmid>7100063</pmid><doi>10.3382/ps.0610777</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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ispartof | Poultry science, 1982-04, Vol.61 (4), p.777-784 |
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language | eng |
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source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
subjects | Animals Cartilage - metabolism Chickens - growth & development Dwarfism - physiopathology Dwarfism - veterinary Fatty Acids, Nonesterified - blood Female Growth Hormone - blood Male Poultry Diseases - physiopathology Sex Factors Somatomedins - blood Sulfates - metabolism |
title | Changes in a somatomedin-like factor and immunoassayable growth hormone during growth of normal and dwarf pullets and cockerels |
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