Alpha- 1-Antitrypsin Deficiency—A Cause of Cryptogenic Liver Disease in the Elderly
We report a 73-year-old woman with homozygous ZZ alpha-1-antitrypsin deficiency (AATD), micronodular cirrhosis, cholestatic jaundice, and emphysema. An elevated SGOT/SGPT ratio was noted in the absence of chronic alcoholism. ERCP demonstrated a normal extrahepatic biliary system and suggested obstru...
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| Veröffentlicht in: | Journal of clinical gastroenterology 1982-06, Vol.4 (3), p.269-274 |
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| container_end_page | 274 |
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| container_title | Journal of clinical gastroenterology |
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| creator | Battle, William M Matarazzo, Stephen A Selhat, George F Catalano, Edison |
| description | We report a 73-year-old woman with homozygous ZZ alpha-1-antitrypsin deficiency (AATD), micronodular cirrhosis, cholestatic jaundice, and emphysema. An elevated SGOT/SGPT ratio was noted in the absence of chronic alcoholism. ERCP demonstrated a normal extrahepatic biliary system and suggested obstruction of the intrahepatic ducts. An operative liver biopsy demonstrated periodic acid-Schiff-positive, diastase resistant intracytoplasmic inclusion bodies. This patient reminds us that metabolic causes of cryptogenic liver disease need to be considered, even in the elderly. We review briefly the literature concerning AATD |
| doi_str_mv | 10.1097/00004836-198206000-00014 |
| format | Article |
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An elevated SGOT/SGPT ratio was noted in the absence of chronic alcoholism. ERCP demonstrated a normal extrahepatic biliary system and suggested obstruction of the intrahepatic ducts. An operative liver biopsy demonstrated periodic acid-Schiff-positive, diastase resistant intracytoplasmic inclusion bodies. This patient reminds us that metabolic causes of cryptogenic liver disease need to be considered, even in the elderly. 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We review briefly the literature concerning AATD</description><subject>Aged</subject><subject>Alleles</subject><subject>alpha 1-Antitrypsin - genetics</subject><subject>alpha 1-Antitrypsin Deficiency</subject><subject>Female</subject><subject>Humans</subject><subject>Liver - pathology</subject><subject>Liver Cirrhosis - etiology</subject><subject>Liver Function Tests</subject><subject>Phenotype</subject><issn>0192-0790</issn><issn>1539-2031</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kc9OGzEQxq0KBCn0EZB86s2tvbbX62MU0j9SJC5wtmxnlrh1dlN7l2hvfQiekCfBkMCNkUYj6_u-sfQbhDCj3xjV6jstJRpeE6abitblRUoz8QnNmOSaVJSzEzSjTFeEKk3P0eec_xSH4pydobNaN7Tieobu5nG3sQQzMu-GMKRpl0OHr6ENPkDnp6f_j3O8sGMG3Ld4UfShv4cueLwKD5Dwdchgi1hCwwbwMq4hxekSnbY2ZvhynBfo7sfydvGLrG5-_l7MV8RzKQVxommkdYJLr3nFtNRghfWtVq62jmvnmFR2rbxuvdBKWeuqmleSi9atayn5Bfp62LtL_b8R8mC2IXuI0XbQj9kowWSlhSrG5mD0qc85QWt2KWxtmgyj5oWoeSNq3omaV6IlenX8Y3RbWL8HjwiLLg76vo8DpPw3jntIZgM2Dhvz0aH4M5UogJY</recordid><startdate>198206</startdate><enddate>198206</enddate><creator>Battle, William M</creator><creator>Matarazzo, Stephen A</creator><creator>Selhat, George F</creator><creator>Catalano, Edison</creator><general>Lippincott-Raven Publishers</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>8BM</scope></search><sort><creationdate>198206</creationdate><title>Alpha- 1-Antitrypsin Deficiency—A Cause of Cryptogenic Liver Disease in the Elderly</title><author>Battle, William M ; Matarazzo, Stephen A ; Selhat, George F ; Catalano, Edison</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3554-b4885ab435c9321959ea4acf97b6ab39bb157ad7c9fc4977aab2632534fbd6553</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Aged</topic><topic>Alleles</topic><topic>alpha 1-Antitrypsin - genetics</topic><topic>alpha 1-Antitrypsin Deficiency</topic><topic>Female</topic><topic>Humans</topic><topic>Liver - pathology</topic><topic>Liver Cirrhosis - etiology</topic><topic>Liver Function Tests</topic><topic>Phenotype</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Battle, William M</creatorcontrib><creatorcontrib>Matarazzo, Stephen A</creatorcontrib><creatorcontrib>Selhat, George F</creatorcontrib><creatorcontrib>Catalano, Edison</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>ComDisDome</collection><jtitle>Journal of clinical gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Battle, William M</au><au>Matarazzo, Stephen A</au><au>Selhat, George F</au><au>Catalano, Edison</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alpha- 1-Antitrypsin Deficiency—A Cause of Cryptogenic Liver Disease in the Elderly</atitle><jtitle>Journal of clinical gastroenterology</jtitle><addtitle>J Clin Gastroenterol</addtitle><date>1982-06</date><risdate>1982</risdate><volume>4</volume><issue>3</issue><spage>269</spage><epage>274</epage><pages>269-274</pages><issn>0192-0790</issn><eissn>1539-2031</eissn><abstract>We report a 73-year-old woman with homozygous ZZ alpha-1-antitrypsin deficiency (AATD), micronodular cirrhosis, cholestatic jaundice, and emphysema. 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| identifier | ISSN: 0192-0790 |
| ispartof | Journal of clinical gastroenterology, 1982-06, Vol.4 (3), p.269-274 |
| issn | 0192-0790 1539-2031 |
| language | eng |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Aged Alleles alpha 1-Antitrypsin - genetics alpha 1-Antitrypsin Deficiency Female Humans Liver - pathology Liver Cirrhosis - etiology Liver Function Tests Phenotype |
| title | Alpha- 1-Antitrypsin Deficiency—A Cause of Cryptogenic Liver Disease in the Elderly |
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