Genetic mechanisms of resistance to acyclovir in herpes simplex virus

Resistance to acyclovir in herpes simplex virus (HSV) is mediated by two genetic loci on the herpes virus genome: viral thymldine kinase and DNA polymerase. Passage of HSV in the presence of 10 μ M or 2 μ M acyclovir readily coselects for virus deficient in the expression of viral thymidine kinase a...

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Veröffentlicht in:	The American journal of medicine 1982-07, Vol.73 (1), p.361-368
Hauptverfasser:	Crumpacker, Clyde S., Schnipper, Lowell E., Chartrand, Pierre, Knopf, Karl W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acyclovir Antiviral Agents - pharmacology DNA-Directed DNA Polymerase - genetics DNA-Directed DNA Polymerase - metabolism Drug Resistance, Microbial Genes, Viral Guanine - analogs & derivatives Guanine - pharmacology Mutation Phosphonoacetic Acid - pharmacology Recombination, Genetic Simplexvirus - drug effects Simplexvirus - genetics Thymidine Kinase - genetics Thymidine Kinase - metabolism
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