Localization of opiate and histamine H1-receptors in the primate sensory ganglia and spinal cord
The autoradiographic localizations of opiate and histamine H1-receptors were studied quantitatively and compared following dorsal root section in the primate spinal cord. High densities of opiate and H1-receptors were found in the superficial layers of the dorsal horn. Dorsal root section produced a...
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| Veröffentlicht in: | Brain research 1982-06, Vol.241 (2), p.197-206 |
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| creator | Ninkovic, M Hunt, S P Gleave, J R |
| description | The autoradiographic localizations of opiate and histamine H1-receptors were studied quantitatively and compared following dorsal root section in the primate spinal cord. High densities of opiate and H1-receptors were found in the superficial layers of the dorsal horn. Dorsal root section produced a 40-50% loss of both receptors types throughout layers I and II with no loss in deeper layers of the dorsal horn. "Bursts' of opiate and H1-receptor labelling was observed over a population of small diameter cells (35-45 micron or micrometer) in the primate dorsal root ganglion. These cells represented approximately 8% of the total cells present. Serial consecutive sections demonstrated a population of cells bearing both opiate and histamine H1-receptors. |
| doi_str_mv | 10.1016/0006-8993(82)91056-3 |
| format | Article |
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High densities of opiate and H1-receptors were found in the superficial layers of the dorsal horn. Dorsal root section produced a 40-50% loss of both receptors types throughout layers I and II with no loss in deeper layers of the dorsal horn. "Bursts' of opiate and H1-receptor labelling was observed over a population of small diameter cells (35-45 micron or micrometer) in the primate dorsal root ganglion. These cells represented approximately 8% of the total cells present. 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High densities of opiate and H1-receptors were found in the superficial layers of the dorsal horn. Dorsal root section produced a 40-50% loss of both receptors types throughout layers I and II with no loss in deeper layers of the dorsal horn. "Bursts' of opiate and H1-receptor labelling was observed over a population of small diameter cells (35-45 micron or micrometer) in the primate dorsal root ganglion. These cells represented approximately 8% of the total cells present. Serial consecutive sections demonstrated a population of cells bearing both opiate and histamine H1-receptors.</description><subject>Animals</subject><subject>Autoradiography</subject><subject>Etorphine - metabolism</subject><subject>Ganglia, Spinal - metabolism</subject><subject>Macaca mulatta</subject><subject>Pyrilamine - metabolism</subject><subject>Receptors, Histamine - metabolism</subject><subject>Receptors, Histamine H1 - metabolism</subject><subject>Receptors, Opioid - metabolism</subject><subject>Spinal Cord - metabolism</subject><subject>Tritium</subject><issn>0006-8993</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1OwzAQhH0AlVJ4A5B8QnAI-Cdx4iNCQJEqcYGzWZxNa5TYwU4P5elp2qqXXe1qZqT5CLni7J4zrh4YYyqrtJa3lbjTnBUqkydkenyfkfOUfranlJpNyESJSrGcT8nXIlho3R8MLngaGhp6BwNS8DVduTRA5zzSOc8iWuyHEBN1ng4rpH103ahM6FOIG7oEv2wd7Jypdx5aakOsL8hpA23Cy8Oekc-X54-nebZ4f317elxkVqpqyBQwJZjWDAqpLNY5EyVXBQdZC1vnSkppa1Gi0EyCxNLmhW04ImyHhUrLGbnZ5_Yx_K4xDaZzyWLbgsewTqbMeV6OKGYk3wttDClFbMyuSdwYzswI04zUzCg1lTA7mEZubdeH_PV3h_XRdCAp_wF573It</recordid><startdate>19820610</startdate><enddate>19820610</enddate><creator>Ninkovic, M</creator><creator>Hunt, S P</creator><creator>Gleave, J R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19820610</creationdate><title>Localization of opiate and histamine H1-receptors in the primate sensory ganglia and spinal cord</title><author>Ninkovic, M ; Hunt, S P ; Gleave, J R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c368t-6a0620990a536ced40271651a3d2cd46333cd27e2903a3e7c45cf1eeaf1eca893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Autoradiography</topic><topic>Etorphine - metabolism</topic><topic>Ganglia, Spinal - metabolism</topic><topic>Macaca mulatta</topic><topic>Pyrilamine - metabolism</topic><topic>Receptors, Histamine - metabolism</topic><topic>Receptors, Histamine H1 - metabolism</topic><topic>Receptors, Opioid - metabolism</topic><topic>Spinal Cord - metabolism</topic><topic>Tritium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ninkovic, M</creatorcontrib><creatorcontrib>Hunt, S P</creatorcontrib><creatorcontrib>Gleave, J R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Brain research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ninkovic, M</au><au>Hunt, S P</au><au>Gleave, J R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Localization of opiate and histamine H1-receptors in the primate sensory ganglia and spinal cord</atitle><jtitle>Brain research</jtitle><addtitle>Brain Res</addtitle><date>1982-06-10</date><risdate>1982</risdate><volume>241</volume><issue>2</issue><spage>197</spage><epage>206</epage><pages>197-206</pages><issn>0006-8993</issn><abstract>The autoradiographic localizations of opiate and histamine H1-receptors were studied quantitatively and compared following dorsal root section in the primate spinal cord. 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| ispartof | Brain research, 1982-06, Vol.241 (2), p.197-206 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Autoradiography Etorphine - metabolism Ganglia, Spinal - metabolism Macaca mulatta Pyrilamine - metabolism Receptors, Histamine - metabolism Receptors, Histamine H1 - metabolism Receptors, Opioid - metabolism Spinal Cord - metabolism Tritium |
| title | Localization of opiate and histamine H1-receptors in the primate sensory ganglia and spinal cord |
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