Pinazepam: a precursor of N-desmethyldiazepam
The plasma profile of a single oral dose of pinazepam 10 mg was studied in 6 healthy male volunteers, aged 26 to 31 years. The concentrations of the parent compound and of its metabolite in plasma were measured by gas-chromatography. The peak plasma levels of pinazepam was 36.8 +/- 5.1 ng/ml and of...
Gespeichert in:
| Veröffentlicht in: | European journal of clinical pharmacology 1982-01, Vol.22 (3), p.225-228 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 228 |
|---|---|
| container_issue | 3 |
| container_start_page | 225 |
| container_title | European journal of clinical pharmacology |
| container_volume | 22 |
| creator | Pacifici, G M Placidi, G F Fornaro, P Gomeni, R |
| description | The plasma profile of a single oral dose of pinazepam 10 mg was studied in 6 healthy male volunteers, aged 26 to 31 years. The concentrations of the parent compound and of its metabolite in plasma were measured by gas-chromatography. The peak plasma levels of pinazepam was 36.8 +/- 5.1 ng/ml and of N-desmethyldiazepam 150 +/- 13.3 ng/ml. The plasma concentration of the metabolite become higher than that of the parent compound shortly after administration, suggesting that pinazepam acts as a prodrug. |
| doi_str_mv | 10.1007/BF00545219 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_74144380</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>74144380</sourcerecordid><originalsourceid>FETCH-LOGICAL-c282t-b1d8e7a5336a822e7d9837bf2980942786fef40cf4bef94e478663882ef7d0893</originalsourceid><addsrcrecordid>eNpFkE1LxDAURYMoYx3duBe6ciFEXz7aJO50cFQY1IWuS9q-YKWd1qRdjL_eDi26unA53AuHkHMG1wxA3dyvARKZcGYOSMSk4JSBZIckAhCMpkbBMTkJ4QuAJQbEgixSDUYqFRH6Vm3tD3a2uY1t3HksBh9aH7cufqElhgb7z11dVhNzSo6crQOezbkkH-uH99UT3bw-Pq_uNrTgmvc0Z6VGZRMhUqs5R1UaLVTuuNnfcqVTh05C4WSOzkiUY5MKrTk6VYI2Ykkup93Ot98Dhj5rqlBgXdsttkPIlGRSCg0jeDWBhW9D8OiyzleN9buMQbZ3k_27GeGLeXXIGyz_0FmG-AUIj1xs</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74144380</pqid></control><display><type>article</type><title>Pinazepam: a precursor of N-desmethyldiazepam</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Pacifici, G M ; Placidi, G F ; Fornaro, P ; Gomeni, R</creator><creatorcontrib>Pacifici, G M ; Placidi, G F ; Fornaro, P ; Gomeni, R</creatorcontrib><description>The plasma profile of a single oral dose of pinazepam 10 mg was studied in 6 healthy male volunteers, aged 26 to 31 years. The concentrations of the parent compound and of its metabolite in plasma were measured by gas-chromatography. The peak plasma levels of pinazepam was 36.8 +/- 5.1 ng/ml and of N-desmethyldiazepam 150 +/- 13.3 ng/ml. The plasma concentration of the metabolite become higher than that of the parent compound shortly after administration, suggesting that pinazepam acts as a prodrug.</description><identifier>ISSN: 0031-6970</identifier><identifier>EISSN: 1432-1041</identifier><identifier>DOI: 10.1007/BF00545219</identifier><identifier>PMID: 6809477</identifier><language>eng</language><publisher>Germany</publisher><subject>Adult ; Anti-Anxiety Agents ; Benzodiazepines ; Benzodiazepinones - blood ; Diazepam - analogs & derivatives ; Half-Life ; Humans ; Kinetics ; Male ; Nordazepam - blood</subject><ispartof>European journal of clinical pharmacology, 1982-01, Vol.22 (3), p.225-228</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c282t-b1d8e7a5336a822e7d9837bf2980942786fef40cf4bef94e478663882ef7d0893</citedby><cites>FETCH-LOGICAL-c282t-b1d8e7a5336a822e7d9837bf2980942786fef40cf4bef94e478663882ef7d0893</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,782,786,27933,27934</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6809477$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pacifici, G M</creatorcontrib><creatorcontrib>Placidi, G F</creatorcontrib><creatorcontrib>Fornaro, P</creatorcontrib><creatorcontrib>Gomeni, R</creatorcontrib><title>Pinazepam: a precursor of N-desmethyldiazepam</title><title>European journal of clinical pharmacology</title><addtitle>Eur J Clin Pharmacol</addtitle><description>The plasma profile of a single oral dose of pinazepam 10 mg was studied in 6 healthy male volunteers, aged 26 to 31 years. The concentrations of the parent compound and of its metabolite in plasma were measured by gas-chromatography. The peak plasma levels of pinazepam was 36.8 +/- 5.1 ng/ml and of N-desmethyldiazepam 150 +/- 13.3 ng/ml. The plasma concentration of the metabolite become higher than that of the parent compound shortly after administration, suggesting that pinazepam acts as a prodrug.</description><subject>Adult</subject><subject>Anti-Anxiety Agents</subject><subject>Benzodiazepines</subject><subject>Benzodiazepinones - blood</subject><subject>Diazepam - analogs & derivatives</subject><subject>Half-Life</subject><subject>Humans</subject><subject>Kinetics</subject><subject>Male</subject><subject>Nordazepam - blood</subject><issn>0031-6970</issn><issn>1432-1041</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1LxDAURYMoYx3duBe6ciFEXz7aJO50cFQY1IWuS9q-YKWd1qRdjL_eDi26unA53AuHkHMG1wxA3dyvARKZcGYOSMSk4JSBZIckAhCMpkbBMTkJ4QuAJQbEgixSDUYqFRH6Vm3tD3a2uY1t3HksBh9aH7cufqElhgb7z11dVhNzSo6crQOezbkkH-uH99UT3bw-Pq_uNrTgmvc0Z6VGZRMhUqs5R1UaLVTuuNnfcqVTh05C4WSOzkiUY5MKrTk6VYI2Ykkup93Ot98Dhj5rqlBgXdsttkPIlGRSCg0jeDWBhW9D8OiyzleN9buMQbZ3k_27GeGLeXXIGyz_0FmG-AUIj1xs</recordid><startdate>19820101</startdate><enddate>19820101</enddate><creator>Pacifici, G M</creator><creator>Placidi, G F</creator><creator>Fornaro, P</creator><creator>Gomeni, R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19820101</creationdate><title>Pinazepam: a precursor of N-desmethyldiazepam</title><author>Pacifici, G M ; Placidi, G F ; Fornaro, P ; Gomeni, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c282t-b1d8e7a5336a822e7d9837bf2980942786fef40cf4bef94e478663882ef7d0893</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Anti-Anxiety Agents</topic><topic>Benzodiazepines</topic><topic>Benzodiazepinones - blood</topic><topic>Diazepam - analogs & derivatives</topic><topic>Half-Life</topic><topic>Humans</topic><topic>Kinetics</topic><topic>Male</topic><topic>Nordazepam - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pacifici, G M</creatorcontrib><creatorcontrib>Placidi, G F</creatorcontrib><creatorcontrib>Fornaro, P</creatorcontrib><creatorcontrib>Gomeni, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pacifici, G M</au><au>Placidi, G F</au><au>Fornaro, P</au><au>Gomeni, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pinazepam: a precursor of N-desmethyldiazepam</atitle><jtitle>European journal of clinical pharmacology</jtitle><addtitle>Eur J Clin Pharmacol</addtitle><date>1982-01-01</date><risdate>1982</risdate><volume>22</volume><issue>3</issue><spage>225</spage><epage>228</epage><pages>225-228</pages><issn>0031-6970</issn><eissn>1432-1041</eissn><abstract>The plasma profile of a single oral dose of pinazepam 10 mg was studied in 6 healthy male volunteers, aged 26 to 31 years. The concentrations of the parent compound and of its metabolite in plasma were measured by gas-chromatography. The peak plasma levels of pinazepam was 36.8 +/- 5.1 ng/ml and of N-desmethyldiazepam 150 +/- 13.3 ng/ml. The plasma concentration of the metabolite become higher than that of the parent compound shortly after administration, suggesting that pinazepam acts as a prodrug.</abstract><cop>Germany</cop><pmid>6809477</pmid><doi>10.1007/BF00545219</doi><tpages>4</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0031-6970 |
| ispartof | European journal of clinical pharmacology, 1982-01, Vol.22 (3), p.225-228 |
| issn | 0031-6970 1432-1041 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74144380 |
| source | MEDLINE; SpringerNature Journals |
| subjects | Adult Anti-Anxiety Agents Benzodiazepines Benzodiazepinones - blood Diazepam - analogs & derivatives Half-Life Humans Kinetics Male Nordazepam - blood |
| title | Pinazepam: a precursor of N-desmethyldiazepam |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-02T06%3A46%3A55IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Pinazepam:%20a%20precursor%20of%20N-desmethyldiazepam&rft.jtitle=European%20journal%20of%20clinical%20pharmacology&rft.au=Pacifici,%20G%20M&rft.date=1982-01-01&rft.volume=22&rft.issue=3&rft.spage=225&rft.epage=228&rft.pages=225-228&rft.issn=0031-6970&rft.eissn=1432-1041&rft_id=info:doi/10.1007/BF00545219&rft_dat=%3Cproquest_cross%3E74144380%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=74144380&rft_id=info:pmid/6809477&rfr_iscdi=true |