effect of vitamin E on platelet kinetics of stroke-prone spontaneously hypertensive rats (SHRSP)

The platelet survival time was shortened in stroke-prone spontaneously hypertensive rats (SHRSP) at 10 weeks of age on feeding the regular diet but it was normalized on administering the vitamin E-supplemented diet. Platelet survival time was normal in stroke-resistant spontaneously hypertensive rat...

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Veröffentlicht in:Journal of Nutritional Science and Vitaminology 1982, Vol.28(1), pp.1-10
Hauptverfasser: Koganemaru, S, Kuramoto, A
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creator Koganemaru, S
Kuramoto, A
description The platelet survival time was shortened in stroke-prone spontaneously hypertensive rats (SHRSP) at 10 weeks of age on feeding the regular diet but it was normalized on administering the vitamin E-supplemented diet. Platelet survival time was normal in stroke-resistant spontaneously hypertensive rats (SHRSR) at 10 weeks of age on feeding the regular diet but it was shortened when supplying the vitamin E-free diet. The maximal uptake of 75Se-selenomethionine by platelets was in-creased in SHRSP at 10 weeks of age on feeding the regular diet. It was further increased in SHRSP on feeding the vitamin E-free diet. On the other hand, the increased maximal uptake of 75 Se-selenomethionine by platelets was normalized in SHRSP on feeding both the vitamin E-supplemented diet and the vitamin E-supplemented diet after administer-ing the vitamin E-free diet. Therefore, we concluded that the deficiency of vitamin E brought about the shortening of platelet survival time and enhanced platelet production.
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Platelet survival time was normal in stroke-resistant spontaneously hypertensive rats (SHRSR) at 10 weeks of age on feeding the regular diet but it was shortened when supplying the vitamin E-free diet. The maximal uptake of 75Se-selenomethionine by platelets was in-creased in SHRSP at 10 weeks of age on feeding the regular diet. It was further increased in SHRSP on feeding the vitamin E-free diet. On the other hand, the increased maximal uptake of 75 Se-selenomethionine by platelets was normalized in SHRSP on feeding both the vitamin E-supplemented diet and the vitamin E-supplemented diet after administer-ing the vitamin E-free diet. 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source J-STAGE Free; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
subjects 75Se-selenomethionine
Animals
Blood Platelets - physiology
Cell Survival - drug effects
Cerebrovascular Disorders - blood
diet-related diseases
Disease Susceptibility
Female
human nutrition
Hypertension - blood
Hypertension - genetics
Kinetics
Male
Platelet Count
platelet kinetics
Rats
Rats, Inbred Strains
Selenium - metabolism
Selenomethionine - metabolism
SHRSP
SHRSR
vitamin E
Vitamin E - pharmacology
Vitamin E Deficiency - blood
title effect of vitamin E on platelet kinetics of stroke-prone spontaneously hypertensive rats (SHRSP)
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