Platelet size in health and hematologic disease
In normal subjects, mean platelet volume (MPV) has an inverse, nonlinear relation with platelet count, while platelet volume heterogeneity has a direct, nonlinear relation with MPV. Compared with the reference range established for normal subjects, patients with chronic lymphocytic leukemia, atheros...
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| Veröffentlicht in: | American journal of clinical pathology 1982-08, Vol.78 (2), p.150-153 |
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| container_title | American journal of clinical pathology |
| container_volume | 78 |
| creator | Bessman, J D Williams, L J Gilmer, Jr, P R |
| description | In normal subjects, mean platelet volume (MPV) has an inverse, nonlinear relation with platelet count, while platelet volume heterogeneity has a direct, nonlinear relation with MPV. Compared with the reference range established for normal subjects, patients with chronic lymphocytic leukemia, atherosclerotic heart disease, diabetes mellitus, and chronic undifferentiated schizophrenia had normal platelet volume mean and heterogeneity. Patients treated with cytotoxic chemotherapy for acute nonlymphocytic leukemia, patients with megaloblastic anemia, and patients with aplastic anemia had abnormally small platelets with increased heterogeneity. Patients with chronic myelogenous leukemia had abnormally large platelets with increased heterogeneity. |
| doi_str_mv | 10.1093/ajcp/78.2.150 |
| format | Article |
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Compared with the reference range established for normal subjects, patients with chronic lymphocytic leukemia, atherosclerotic heart disease, diabetes mellitus, and chronic undifferentiated schizophrenia had normal platelet volume mean and heterogeneity. Patients treated with cytotoxic chemotherapy for acute nonlymphocytic leukemia, patients with megaloblastic anemia, and patients with aplastic anemia had abnormally small platelets with increased heterogeneity. 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Compared with the reference range established for normal subjects, patients with chronic lymphocytic leukemia, atherosclerotic heart disease, diabetes mellitus, and chronic undifferentiated schizophrenia had normal platelet volume mean and heterogeneity. Patients treated with cytotoxic chemotherapy for acute nonlymphocytic leukemia, patients with megaloblastic anemia, and patients with aplastic anemia had abnormally small platelets with increased heterogeneity. Patients with chronic myelogenous leukemia had abnormally large platelets with increased heterogeneity.</description><subject>Anemia, Megaloblastic - blood</subject><subject>Arteriosclerosis - blood</subject><subject>Blood Platelets - physiology</subject><subject>Blood Volume</subject><subject>Diabetes Mellitus - blood</subject><subject>Female</subject><subject>Hematologic Diseases - blood</subject><subject>Humans</subject><subject>Leukemia, Lymphoid - blood</subject><subject>Leukemia, Myeloid - blood</subject><subject>Male</subject><subject>Platelet Count</subject><subject>Schizophrenia - blood</subject><issn>0002-9173</issn><issn>1943-7722</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kDtPwzAURi0EKqUwMiJlYkt6_cq1R1TxkirBALPlV2kqpylxOsCvJ1Urpu8bjs5wCLmlUFHQfG43fjdHVbGKSjgjU6oFLxEZOydTAGClpsgvyVXOGwDKFIgJmdRaCiVhSubvyQ4xxaHIzW8smm2xjjYN68Juw3hbO3Sp-2p8EZocbY7X5GJlU443p52Rz6fHj8VLuXx7fl08LEvPpRhKVE5xEC445bUTAX1NqXMI0tc-QI2UOxQYHRfOaRX0ylHUWgO3HrlkfEbuj95d333vYx5M22QfU7Lb2O2zQUEFBalGsDyCvu9y7uPK7Pqmtf2PoWAOgcwhkEFlmBkDjfzdSbx3bQz_9KkI_wPj7mBQ</recordid><startdate>198208</startdate><enddate>198208</enddate><creator>Bessman, J D</creator><creator>Williams, L J</creator><creator>Gilmer, Jr, P R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198208</creationdate><title>Platelet size in health and hematologic disease</title><author>Bessman, J D ; Williams, L J ; Gilmer, Jr, P R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c354t-78b8304bdb8c9b4d7c611bb705c6cd06713b747eb34bb98d9fb1799903ac73523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Anemia, Megaloblastic - blood</topic><topic>Arteriosclerosis - blood</topic><topic>Blood Platelets - physiology</topic><topic>Blood Volume</topic><topic>Diabetes Mellitus - blood</topic><topic>Female</topic><topic>Hematologic Diseases - blood</topic><topic>Humans</topic><topic>Leukemia, Lymphoid - blood</topic><topic>Leukemia, Myeloid - blood</topic><topic>Male</topic><topic>Platelet Count</topic><topic>Schizophrenia - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bessman, J D</creatorcontrib><creatorcontrib>Williams, L J</creatorcontrib><creatorcontrib>Gilmer, Jr, P R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of clinical pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bessman, J D</au><au>Williams, L J</au><au>Gilmer, Jr, P R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Platelet size in health and hematologic disease</atitle><jtitle>American journal of clinical pathology</jtitle><addtitle>Am J Clin Pathol</addtitle><date>1982-08</date><risdate>1982</risdate><volume>78</volume><issue>2</issue><spage>150</spage><epage>153</epage><pages>150-153</pages><issn>0002-9173</issn><eissn>1943-7722</eissn><abstract>In normal subjects, mean platelet volume (MPV) has an inverse, nonlinear relation with platelet count, while platelet volume heterogeneity has a direct, nonlinear relation with MPV. 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| fulltext | fulltext |
| identifier | ISSN: 0002-9173 |
| ispartof | American journal of clinical pathology, 1982-08, Vol.78 (2), p.150-153 |
| issn | 0002-9173 1943-7722 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74141058 |
| source | Oxford University Press Journals Digital Archive legacy; MEDLINE |
| subjects | Anemia, Megaloblastic - blood Arteriosclerosis - blood Blood Platelets - physiology Blood Volume Diabetes Mellitus - blood Female Hematologic Diseases - blood Humans Leukemia, Lymphoid - blood Leukemia, Myeloid - blood Male Platelet Count Schizophrenia - blood |
| title | Platelet size in health and hematologic disease |
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