THIOLACTOMYCIN, A NEW ANTIBIOTIC: III. IN VITRO ANTIBACTERIAL ACTIVITY
Thiolactomycin is a new broad-spectrum antibiotic, active in vitro against many species of Gram-positive cocci, Enterobacteriaceae, Haemophilus, acid-fast bacteria and anaerobic bacteria. However, the activity is generally moderate and bacteriostatic in action. This antibiotic eludes cross resistanc...
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| Veröffentlicht in: | Journal of antibiotics 1982, Vol.35(4), pp.401-410 |
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| container_end_page | 410 |
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| container_issue | 4 |
| container_start_page | 401 |
| container_title | Journal of antibiotics |
| container_volume | 35 |
| creator | NOTO, TAKAO MIYAKAWA, SATOHIDE OISHI, HIDEO ENDO, HISAO OKAZAKI, HIROSHI |
| description | Thiolactomycin is a new broad-spectrum antibiotic, active in vitro against many species of Gram-positive cocci, Enterobacteriaceae, Haemophilus, acid-fast bacteria and anaerobic bacteria. However, the activity is generally moderate and bacteriostatic in action. This antibiotic eludes cross resistance with any of the known antibacterial drugs such as ampicill in, carbenicillin or cycloserine. The effect on Gram-negative bacilli in vitro is little affected by the inoculum size, the presence of horse serum, the pH of the medium or the type of medium. When thiolactomycin was added to the assay medium, the minimum inhibitory concentration of ampicillin against inducible β-lactamase producing strains of Staphylococcus aureus and Pseudonzonasa eruginosa was reduced. Thiolactomycin inhibited the production of inducible β-lactamase in several organisms. |
| doi_str_mv | 10.7164/antibiotics.35.401 |
| format | Article |
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When thiolactomycin was added to the assay medium, the minimum inhibitory concentration of ampicillin against inducible β-lactamase producing strains of Staphylococcus aureus and Pseudonzonasa eruginosa was reduced. 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Thiolactomycin inhibited the production of inducible β-lactamase in several organisms.</description><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Bacteria - drug effects</subject><subject>Bacteria - enzymology</subject><subject>beta-Lactamase Inhibitors</subject><subject>Enterobacteriaceae</subject><subject>Haemophilus</subject><subject>Lactones - pharmacology</subject><subject>Microbial Sensitivity Tests</subject><subject>Pseudomonas aeruginosa</subject><subject>Thiophenes</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkL1OwzAURi0EKqXwAkhImZhIseP_MUSFRpRmCUJMluM4kCptIE4H3h5DqqobLPcO37lHVx8AlwhOOWLkVm_6uqjbvjZuiumUQHQExkgIFCLC5DEYQxihUIgInoIz51YQYo65GIERk8JHdAyCfJ5mizjJs6fXJF3eBHGwnL0E8TJP79IsT5NzcFLpxtmL3Z6A5_tZnszDRfaQJvEiNIRiFBYwokxAxmWBC2wqJsrCFFZEHGmi_TvGGiupjHQJS2Y5RYjxyjJtOa8ktHgCrgfvR9d-bq3r1bp2xjaN3th26xQniECMyZ8gohRSgvE_QEIkiqgHowE0XetcZyv10dVr3X0pBNVP0eqgaIWp8kX7o6udfVusbbk_2TXr88chX7lev9l9rjtvaeyhEkkmfrXD8PY9Zd51p-wGfwNFppKC</recordid><startdate>1982</startdate><enddate>1982</enddate><creator>NOTO, TAKAO</creator><creator>MIYAKAWA, SATOHIDE</creator><creator>OISHI, HIDEO</creator><creator>ENDO, HISAO</creator><creator>OKAZAKI, HIROSHI</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>1982</creationdate><title>THIOLACTOMYCIN, A NEW ANTIBIOTIC</title><author>NOTO, TAKAO ; MIYAKAWA, SATOHIDE ; OISHI, HIDEO ; ENDO, HISAO ; OKAZAKI, HIROSHI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4531-b025680679b3b3cf68dbcbe8271a4a146cece9592ad0d6e751167fe6ae77f90e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Bacteria - drug effects</topic><topic>Bacteria - enzymology</topic><topic>beta-Lactamase Inhibitors</topic><topic>Enterobacteriaceae</topic><topic>Haemophilus</topic><topic>Lactones - pharmacology</topic><topic>Microbial Sensitivity Tests</topic><topic>Pseudomonas aeruginosa</topic><topic>Thiophenes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>NOTO, TAKAO</creatorcontrib><creatorcontrib>MIYAKAWA, SATOHIDE</creatorcontrib><creatorcontrib>OISHI, HIDEO</creatorcontrib><creatorcontrib>ENDO, HISAO</creatorcontrib><creatorcontrib>OKAZAKI, HIROSHI</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>NOTO, TAKAO</au><au>MIYAKAWA, SATOHIDE</au><au>OISHI, HIDEO</au><au>ENDO, HISAO</au><au>OKAZAKI, HIROSHI</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>THIOLACTOMYCIN, A NEW ANTIBIOTIC: III. 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| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1982, Vol.35(4), pp.401-410 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74140334 |
| source | MEDLINE; J-STAGE |
| subjects | Anti-Bacterial Agents - pharmacology Bacteria - drug effects Bacteria - enzymology beta-Lactamase Inhibitors Enterobacteriaceae Haemophilus Lactones - pharmacology Microbial Sensitivity Tests Pseudomonas aeruginosa Thiophenes |
| title | THIOLACTOMYCIN, A NEW ANTIBIOTIC: III. IN VITRO ANTIBACTERIAL ACTIVITY |
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