The action of disodium cromoglycate on allergen-induced bronchoconstriction
The influence of DSCG administered to the upper and lower area of the air-conducting system on antigen-induced bronchoconstriction was studied in 34 dogs. In high doses DSCG administered to the upper airtract blocked bronchoconstriction and histamine release induced from the lower airways. Bronchoco...
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| Veröffentlicht in: | Research in experimental medicine 1982-01, Vol.180 (2), p.127-137 |
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| container_title | Research in experimental medicine |
| container_volume | 180 |
| creator | Zimmermann, I Ulmer, W T |
| description | The influence of DSCG administered to the upper and lower area of the air-conducting system on antigen-induced bronchoconstriction was studied in 34 dogs. In high doses DSCG administered to the upper airtract blocked bronchoconstriction and histamine release induced from the lower airways. Bronchoconstriction and histamine release originating from the upper airtract were not completely blocked by this kind of drug administration. Effects were differently strong in the individual animals. High doses of DSCG, administered to the lower airways, showed significant effect on bronchoconstriction originating from the lower airways. There was some yet nonsignificant effect on histamine release. Inhibition of respiratory activity without parallel inhibition of histamine release might suggest that plasma histamine concentration does not reflect the mode of action of DSCG in antigen-induced bronchoconstriction. |
| doi_str_mv | 10.1007/BF01851051 |
| format | Article |
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| fulltext | fulltext |
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| ispartof | Research in experimental medicine, 1982-01, Vol.180 (2), p.127-137 |
| issn | 0300-9130 1433-8580 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Animals Ascaris - immunology Bronchi - drug effects Bronchi - physiopathology Bronchial Diseases - drug therapy Bronchial Diseases - etiology Cromolyn Sodium - pharmacology Dogs Female Histamine - blood Histamine Release - drug effects Male Oxygen - blood |
| title | The action of disodium cromoglycate on allergen-induced bronchoconstriction |
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