Inhibition of reverse transcriptase activity of avian myeloblastosis virus by pyrophosphate analogues

Several pyrophosphate analogues have been studied for their effects on avian myeloblastosis virus reverse transcriptase and on cellular DNA polymerase α. Examination of structure-activity relationships for these compounds revealed that two acidic groups connected by a short bridge were necessary, bu...

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Veröffentlicht in:	Antiviral research 1982-01, Vol.2 (1), p.81-95
Hauptverfasser:	Eriksson, Bertil, Stening, Göran, Öberg, Bo
Format:	Artikel
Sprache:	eng
Schlagworte:	AMV reverse transcriptase animal diseases animal health Avian Leukosis Virus - enzymology Avian Myeloblastosis Virus - enzymology Diphosphates - pharmacology Diphosphonates - pharmacology DNA Polymerase II - antagonists & inhibitors Foscarnet inhibitors Kinetics Phosphonoacetic Acid - analogs & derivatives Phosphonoacetic Acid - pharmacology phosphonoformate Polydeoxyribonucleotides - pharmacology pyrophosphate analogues Reverse Transcriptase Inhibitors Structure-Activity Relationship viral diseases of animals and humans
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