Mechanism of Macrophage-Mediated Tumor Cell Cytotoxicity

Activated macrophages inhibit the incorporation of 125IUDR into the DNA of Lewis lung cells and lead to the cytotoxicity of these target tumor cells. Despite this apparent inhibition of DNA synthesis, an early increase in the number of Lewis lung (LL) cells occurs when LL is cultured with activated...

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Veröffentlicht in:	The Journal of immunology (1950) 1978-11, Vol.121 (5), p.1781-1789
Hauptverfasser:	Kaplan, Alan M, Brown, Judith, Collins, James M, Morahan, Page S, Snodgrass, Michael J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Division Cell Transformation, Neoplastic Cells, Cultured Cytotoxicity, Immunologic DNA - metabolism Lung Neoplasms - immunology Macrophages - cytology Macrophages - immunology Male Metaphase Mice Mice, Inbred C57BL Neoplasms, Experimental - immunology Uridine - metabolism
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