Natural history of dysgerminoma
Data on 56 patients with pure dysgerminoma are discussed. Forty-nine patients were classified as having new disease or were to have reassessment of disease, and seven cases were to be restaged (one with and six without clinical evidence of disease). Of new and reassessment cases, 44 patients underwe...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1982-08, Vol.143 (7), p.799-807 |
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| creator | De Palo, Giuseppe Pilotti, Silvana Kenda, Rado Ratti, Elisabetta Musumeci, Renato Mangioni, Costantino Di Re, Francesco Lattuada, Angelo Conti, Umberta Cefis, Francesco Recanatini, Liliana Carinelli, Silvestro Rossi, Gianfranco |
| description | Data on 56 patients with pure dysgerminoma are discussed. Forty-nine patients were classified as having new disease or were to have reassessment of disease, and seven cases were to be restaged (one with and six without clinical evidence of disease). Of new and reassessment cases, 44 patients underwent lymphography, 16 underwent peritoneoscopy with diaphragmatic inspection and 30 had peritoneal cytologic testing performed. Positive lymphography resulted in restaging in 31.6% of patients. Diaphragmatic inspection was always negative. Peritoneal cytologic testing was positive for malignant cells in three patients and worsened the stage in one. Pathologic staging of disease was as follows: Stage IA, 24; Stage IB, one; Stage IC, one; Stage III peritoneal disease, two; Stage III retroperitoneal disease, 12; Stage III peritoneal and retroperitoneal disease; four. The 5-year relapse-free survival rates were 91% in patients with pathologic Stages IA, IB, and IC; 74% in those with Stage III retroperitoneal disease and 24% in patients with Stage III peritoneal disease or peritoneal plus retroperitoneal disease. The results indicate that the prognosis is excellent for patients with Stage I and Stage III retroperitoneal disease whereas peritoneal involvement is associated with a poor prognosis. |
| doi_str_mv | 10.1016/0002-9378(82)90013-8 |
| format | Article |
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Forty-nine patients were classified as having new disease or were to have reassessment of disease, and seven cases were to be restaged (one with and six without clinical evidence of disease). Of new and reassessment cases, 44 patients underwent lymphography, 16 underwent peritoneoscopy with diaphragmatic inspection and 30 had peritoneal cytologic testing performed. Positive lymphography resulted in restaging in 31.6% of patients. Diaphragmatic inspection was always negative. Peritoneal cytologic testing was positive for malignant cells in three patients and worsened the stage in one. Pathologic staging of disease was as follows: Stage IA, 24; Stage IB, one; Stage IC, one; Stage III peritoneal disease, two; Stage III retroperitoneal disease, 12; Stage III peritoneal and retroperitoneal disease; four. The 5-year relapse-free survival rates were 91% in patients with pathologic Stages IA, IB, and IC; 74% in those with Stage III retroperitoneal disease and 24% in patients with Stage III peritoneal disease or peritoneal plus retroperitoneal disease. The results indicate that the prognosis is excellent for patients with Stage I and Stage III retroperitoneal disease whereas peritoneal involvement is associated with a poor prognosis.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(82)90013-8</identifier><identifier>PMID: 6213157</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Ascitic Fluid - cytology ; Child ; Dysgerminoma - diagnosis ; Dysgerminoma - pathology ; Female ; Follow-Up Studies ; Humans ; Laparoscopy ; Laparotomy ; Lymphography ; Middle Aged ; Neoplasm Staging ; Ovarian Neoplasms - diagnosis ; Ovarian Neoplasms - pathology ; Peritoneal Neoplasms - secondary ; Prognosis ; Recurrence ; Retroperitoneal Neoplasms - secondary ; Retrospective Studies</subject><ispartof>American journal of obstetrics and gynecology, 1982-08, Vol.143 (7), p.799-807</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-fda9aef7e8d913e6b2f854f83aec4d0929ab74cdc4bc5842dc7f1259e060a5a3</citedby><cites>FETCH-LOGICAL-c357t-fda9aef7e8d913e6b2f854f83aec4d0929ab74cdc4bc5842dc7f1259e060a5a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0002937882900138$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6213157$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>De Palo, Giuseppe</creatorcontrib><creatorcontrib>Pilotti, Silvana</creatorcontrib><creatorcontrib>Kenda, Rado</creatorcontrib><creatorcontrib>Ratti, Elisabetta</creatorcontrib><creatorcontrib>Musumeci, Renato</creatorcontrib><creatorcontrib>Mangioni, Costantino</creatorcontrib><creatorcontrib>Di Re, Francesco</creatorcontrib><creatorcontrib>Lattuada, Angelo</creatorcontrib><creatorcontrib>Conti, Umberta</creatorcontrib><creatorcontrib>Cefis, Francesco</creatorcontrib><creatorcontrib>Recanatini, Liliana</creatorcontrib><creatorcontrib>Carinelli, Silvestro</creatorcontrib><creatorcontrib>Rossi, Gianfranco</creatorcontrib><title>Natural history of dysgerminoma</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>Data on 56 patients with pure dysgerminoma are discussed. Forty-nine patients were classified as having new disease or were to have reassessment of disease, and seven cases were to be restaged (one with and six without clinical evidence of disease). Of new and reassessment cases, 44 patients underwent lymphography, 16 underwent peritoneoscopy with diaphragmatic inspection and 30 had peritoneal cytologic testing performed. Positive lymphography resulted in restaging in 31.6% of patients. Diaphragmatic inspection was always negative. Peritoneal cytologic testing was positive for malignant cells in three patients and worsened the stage in one. Pathologic staging of disease was as follows: Stage IA, 24; Stage IB, one; Stage IC, one; Stage III peritoneal disease, two; Stage III retroperitoneal disease, 12; Stage III peritoneal and retroperitoneal disease; four. The 5-year relapse-free survival rates were 91% in patients with pathologic Stages IA, IB, and IC; 74% in those with Stage III retroperitoneal disease and 24% in patients with Stage III peritoneal disease or peritoneal plus retroperitoneal disease. The results indicate that the prognosis is excellent for patients with Stage I and Stage III retroperitoneal disease whereas peritoneal involvement is associated with a poor prognosis.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Ascitic Fluid - cytology</subject><subject>Child</subject><subject>Dysgerminoma - diagnosis</subject><subject>Dysgerminoma - pathology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Laparoscopy</subject><subject>Laparotomy</subject><subject>Lymphography</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Ovarian Neoplasms - diagnosis</subject><subject>Ovarian Neoplasms - pathology</subject><subject>Peritoneal Neoplasms - secondary</subject><subject>Prognosis</subject><subject>Recurrence</subject><subject>Retroperitoneal Neoplasms - secondary</subject><subject>Retrospective Studies</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UMtKAzEUDaLUWv0Dxa5EF6N5TpKNIMUXFN10HzLJjUZmOprMCP17Z2jp0tXhch6XcxA6J_iWYFLeYYxpoZlU14reaIwJK9QBmhKsZVGqUh2i6V5yjE5y_hpPqukETUpKGBFyii7fbNcnW88_Y-7atJm3Ye43-QNSE9dtY0_RUbB1hrMdztDq6XG1eCmW78-vi4dl4ZiQXRG81RaCBOU1YVBWNCjBg2IWHPdYU20ryZ13vHJCceqdDIQKDbjEVlg2Q1fb2O_U_vSQO9PE7KCu7RraPhvJCVVE8EHIt0KX2pwTBPOdYmPTxhBsxlnMWNKMnY0acJzFqMF2scvvqwb83rTbYeDvtzwMHX8jJJNdhLUDHxO4zvg2_v_gDynecMY</recordid><startdate>19820801</startdate><enddate>19820801</enddate><creator>De Palo, Giuseppe</creator><creator>Pilotti, Silvana</creator><creator>Kenda, Rado</creator><creator>Ratti, Elisabetta</creator><creator>Musumeci, Renato</creator><creator>Mangioni, Costantino</creator><creator>Di Re, Francesco</creator><creator>Lattuada, Angelo</creator><creator>Conti, Umberta</creator><creator>Cefis, Francesco</creator><creator>Recanatini, Liliana</creator><creator>Carinelli, Silvestro</creator><creator>Rossi, Gianfranco</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19820801</creationdate><title>Natural history of dysgerminoma</title><author>De Palo, Giuseppe ; Pilotti, Silvana ; Kenda, Rado ; Ratti, Elisabetta ; Musumeci, Renato ; Mangioni, Costantino ; Di Re, Francesco ; Lattuada, Angelo ; Conti, Umberta ; Cefis, Francesco ; Recanatini, Liliana ; Carinelli, Silvestro ; Rossi, Gianfranco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-fda9aef7e8d913e6b2f854f83aec4d0929ab74cdc4bc5842dc7f1259e060a5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Ascitic Fluid - cytology</topic><topic>Child</topic><topic>Dysgerminoma - diagnosis</topic><topic>Dysgerminoma - pathology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Laparoscopy</topic><topic>Laparotomy</topic><topic>Lymphography</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Ovarian Neoplasms - diagnosis</topic><topic>Ovarian Neoplasms - pathology</topic><topic>Peritoneal Neoplasms - secondary</topic><topic>Prognosis</topic><topic>Recurrence</topic><topic>Retroperitoneal Neoplasms - secondary</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>De Palo, Giuseppe</creatorcontrib><creatorcontrib>Pilotti, Silvana</creatorcontrib><creatorcontrib>Kenda, Rado</creatorcontrib><creatorcontrib>Ratti, Elisabetta</creatorcontrib><creatorcontrib>Musumeci, Renato</creatorcontrib><creatorcontrib>Mangioni, Costantino</creatorcontrib><creatorcontrib>Di Re, Francesco</creatorcontrib><creatorcontrib>Lattuada, Angelo</creatorcontrib><creatorcontrib>Conti, Umberta</creatorcontrib><creatorcontrib>Cefis, Francesco</creatorcontrib><creatorcontrib>Recanatini, Liliana</creatorcontrib><creatorcontrib>Carinelli, Silvestro</creatorcontrib><creatorcontrib>Rossi, Gianfranco</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>De Palo, Giuseppe</au><au>Pilotti, Silvana</au><au>Kenda, Rado</au><au>Ratti, Elisabetta</au><au>Musumeci, Renato</au><au>Mangioni, Costantino</au><au>Di Re, Francesco</au><au>Lattuada, Angelo</au><au>Conti, Umberta</au><au>Cefis, Francesco</au><au>Recanatini, Liliana</au><au>Carinelli, Silvestro</au><au>Rossi, Gianfranco</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Natural history of dysgerminoma</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1982-08-01</date><risdate>1982</risdate><volume>143</volume><issue>7</issue><spage>799</spage><epage>807</epage><pages>799-807</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>Data on 56 patients with pure dysgerminoma are discussed. Forty-nine patients were classified as having new disease or were to have reassessment of disease, and seven cases were to be restaged (one with and six without clinical evidence of disease). Of new and reassessment cases, 44 patients underwent lymphography, 16 underwent peritoneoscopy with diaphragmatic inspection and 30 had peritoneal cytologic testing performed. Positive lymphography resulted in restaging in 31.6% of patients. Diaphragmatic inspection was always negative. Peritoneal cytologic testing was positive for malignant cells in three patients and worsened the stage in one. Pathologic staging of disease was as follows: Stage IA, 24; Stage IB, one; Stage IC, one; Stage III peritoneal disease, two; Stage III retroperitoneal disease, 12; Stage III peritoneal and retroperitoneal disease; four. The 5-year relapse-free survival rates were 91% in patients with pathologic Stages IA, IB, and IC; 74% in those with Stage III retroperitoneal disease and 24% in patients with Stage III peritoneal disease or peritoneal plus retroperitoneal disease. The results indicate that the prognosis is excellent for patients with Stage I and Stage III retroperitoneal disease whereas peritoneal involvement is associated with a poor prognosis.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>6213157</pmid><doi>10.1016/0002-9378(82)90013-8</doi><tpages>9</tpages></addata></record> |
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| ispartof | American journal of obstetrics and gynecology, 1982-08, Vol.143 (7), p.799-807 |
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| subjects | Adolescent Adult Ascitic Fluid - cytology Child Dysgerminoma - diagnosis Dysgerminoma - pathology Female Follow-Up Studies Humans Laparoscopy Laparotomy Lymphography Middle Aged Neoplasm Staging Ovarian Neoplasms - diagnosis Ovarian Neoplasms - pathology Peritoneal Neoplasms - secondary Prognosis Recurrence Retroperitoneal Neoplasms - secondary Retrospective Studies |
| title | Natural history of dysgerminoma |
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