The central antiserotonergic action of mianserin
The central antiserotonergic action of mianserin (MS) was tested in mice, rats, and rabbits. MS, like cyproheptadine, to which it was compared, inhibits the head-twitch response to 5-hydroxytryptophan in mice and rats without affecting the pinna reflex. MS does not change the flexor reflex of the hi...
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| Veröffentlicht in: | Psychopharmacology 1978-01, Vol.59 (1), p.79-84 |
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| creator | Maj, J Sowińska, H Baran, L Gancarczyk, L Rawłów, A |
| description | The central antiserotonergic action of mianserin (MS) was tested in mice, rats, and rabbits. MS, like cyproheptadine, to which it was compared, inhibits the head-twitch response to 5-hydroxytryptophan in mice and rats without affecting the pinna reflex. MS does not change the flexor reflex of the hind limb of the spinal rat; it antagonizes its stimulation induced by fenfluramine, LSD, and quipazine, but not that induced by clonidine. The hyperthermia in rabbits caused by the serotonergic stimulants cited above is also antagonized by pretreatment with MS. Unlike cyproheptadine, MS is not active in the oxotremorine test. The results indicate that at low doses MS is a central serotonergic-receptor blocker. |
| doi_str_mv | 10.1007/bf00428035 |
| format | Article |
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The results indicate that at low doses MS is a central serotonergic-receptor blocker.</description><subject>Animals</subject><subject>Behavior, Animal - drug effects</subject><subject>Body Temperature - drug effects</subject><subject>Dibenzazepines - pharmacology</subject><subject>Hindlimb - drug effects</subject><subject>Lysergic Acid Diethylamide - pharmacology</subject><subject>Male</subject><subject>Mianserin - pharmacology</subject><subject>Mice</subject><subject>Oxotremorine - pharmacology</subject><subject>Quipazine - pharmacology</subject><subject>Rabbits</subject><subject>Rats</subject><subject>Reflex - drug effects</subject><subject>Serotonin</subject><subject>Serotonin Antagonists</subject><subject>Time Factors</subject><issn>0033-3158</issn><issn>1432-2072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkDtPwzAUhS3EqxQWZoZMDEiB61fjjLSigFSJpcyRY1-DUWIXOx3496RqkTjLHc53z_ARck3hngJUD60DEEwBl0dkQgVnJYOKHZMJAOclp1Kdk4ucv2CMUOKMnI5vitYTAutPLAyGIemu0GHwGVMcYsD04U2hzeBjKKIreq_DWPlwSU6c7jJeHe6UvC-f1ouXcvX2_Lp4XJWGzdhQcjYDBDlDZp1RwppatyBNq3jdVtYJ0NKB5lbXKDm6mjsLnHIrpXKKGcGn5Ha_u0nxe4t5aHqfDXadDhi3uakEpaqmdATv9qBJMeeErtkk3-v001Bodnaa-fLPzgjfHFa3bY_2H7rTwX8Bzgdebw</recordid><startdate>197801</startdate><enddate>197801</enddate><creator>Maj, J</creator><creator>Sowińska, H</creator><creator>Baran, L</creator><creator>Gancarczyk, L</creator><creator>Rawłów, A</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197801</creationdate><title>The central antiserotonergic action of mianserin</title><author>Maj, J ; Sowińska, H ; Baran, L ; Gancarczyk, L ; Rawłów, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c262t-3260e056e2dfc84dc9ab05cb839b7df40a5f0a3da9e53ef93fd0313d558f82c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Behavior, Animal - drug effects</topic><topic>Body Temperature - drug effects</topic><topic>Dibenzazepines - pharmacology</topic><topic>Hindlimb - drug effects</topic><topic>Lysergic Acid Diethylamide - pharmacology</topic><topic>Male</topic><topic>Mianserin - pharmacology</topic><topic>Mice</topic><topic>Oxotremorine - pharmacology</topic><topic>Quipazine - pharmacology</topic><topic>Rabbits</topic><topic>Rats</topic><topic>Reflex - drug effects</topic><topic>Serotonin</topic><topic>Serotonin Antagonists</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Maj, J</creatorcontrib><creatorcontrib>Sowińska, H</creatorcontrib><creatorcontrib>Baran, L</creatorcontrib><creatorcontrib>Gancarczyk, L</creatorcontrib><creatorcontrib>Rawłów, A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychopharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Maj, J</au><au>Sowińska, H</au><au>Baran, L</au><au>Gancarczyk, L</au><au>Rawłów, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The central antiserotonergic action of mianserin</atitle><jtitle>Psychopharmacology</jtitle><addtitle>Psychopharmacology (Berl)</addtitle><date>1978-01</date><risdate>1978</risdate><volume>59</volume><issue>1</issue><spage>79</spage><epage>84</epage><pages>79-84</pages><issn>0033-3158</issn><eissn>1432-2072</eissn><abstract>The central antiserotonergic action of mianserin (MS) was tested in mice, rats, and rabbits. 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| fulltext | fulltext |
| identifier | ISSN: 0033-3158 |
| ispartof | Psychopharmacology, 1978-01, Vol.59 (1), p.79-84 |
| issn | 0033-3158 1432-2072 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Animals Behavior, Animal - drug effects Body Temperature - drug effects Dibenzazepines - pharmacology Hindlimb - drug effects Lysergic Acid Diethylamide - pharmacology Male Mianserin - pharmacology Mice Oxotremorine - pharmacology Quipazine - pharmacology Rabbits Rats Reflex - drug effects Serotonin Serotonin Antagonists Time Factors |
| title | The central antiserotonergic action of mianserin |
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