Immunoreactive somatostatin in catecholamine‐producing extra‐adrenal paraganglioma

A patient with catecholamine‐producing extra‐adrenal paraganglioma was found to have a high concentration of immunoreactive somatostatin (IR‐SRIF) in the peripheral blood plasma (47.0 pg/ml, normal; 13.3 ± 5.3 pg/ml, mean ± SD). After removal of the tumor, the plasma SRIF level fell within normal ra...

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Veröffentlicht in:	Cancer 1982-08, Vol.50 (3), p.560-565
Hauptverfasser:	Saito, Haruhiko, Saito, Shiro, Sano, Toshiaki, Kagawa, Noriko, Hizawa, Kazuo, Tatara, Kiyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal Gland Neoplasms - metabolism Adult Epinephrine - blood Female Humans Immunoenzyme Techniques Norepinephrine - blood Paraganglioma - metabolism Paraganglioma - pathology Paraganglioma - surgery Radioimmunoassay Somatostatin - blood
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container_title	Cancer
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creator	Saito, Haruhiko Saito, Shiro Sano, Toshiaki Kagawa, Noriko Hizawa, Kazuo Tatara, Kiyoshi
description	A patient with catecholamine‐producing extra‐adrenal paraganglioma was found to have a high concentration of immunoreactive somatostatin (IR‐SRIF) in the peripheral blood plasma (47.0 pg/ml, normal; 13.3 ± 5.3 pg/ml, mean ± SD). After removal of the tumor, the plasma SRIF level fell within normal range (8.7 pg/ml). In the resected tumor, a considerable amount of IR‐SRIF (71.0 ng/g wet weight) was also detected and SRIF‐positive tumor cells were demonstrated by the immunoperoxidase technique. Chromatographic analysis of an extract of the tumor showed the presence of two IR‐SRIF components of large molecular size besides a component consistent with authentic tetradecapeptide SRIF (SRIF 14), and one of these had the same molecular size as octacosapeptide SRIF (SRIF 28). This seems to be the first report of a catecholamine‐producing extra‐adrenal paraganglioma that produces IR‐SRIF with molecular heterogeneity.
doi_str_mv	10.1002/1097-0142(19820801)50:3<560::AID-CNCR2820500329>3.0.CO;2-I
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After removal of the tumor, the plasma SRIF level fell within normal range (8.7 pg/ml). In the resected tumor, a considerable amount of IR‐SRIF (71.0 ng/g wet weight) was also detected and SRIF‐positive tumor cells were demonstrated by the immunoperoxidase technique. Chromatographic analysis of an extract of the tumor showed the presence of two IR‐SRIF components of large molecular size besides a component consistent with authentic tetradecapeptide SRIF (SRIF 14), and one of these had the same molecular size as octacosapeptide SRIF (SRIF 28). This seems to be the first report of a catecholamine‐producing extra‐adrenal paraganglioma that produces IR‐SRIF with molecular heterogeneity.</description><identifier>ISSN: 0008-543X</identifier><identifier>EISSN: 1097-0142</identifier><identifier>DOI: 10.1002/1097-0142(19820801)50:3<560::AID-CNCR2820500329>3.0.CO;2-I</identifier><identifier>PMID: 6124312</identifier><language>eng</language><publisher>New York: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adrenal Gland Neoplasms - metabolism ; Adult ; Epinephrine - blood ; Female ; Humans ; Immunoenzyme Techniques ; Norepinephrine - blood ; Paraganglioma - metabolism ; Paraganglioma - pathology ; Paraganglioma - surgery ; Radioimmunoassay ; Somatostatin - blood</subject><ispartof>Cancer, 1982-08, Vol.50 (3), p.560-565</ispartof><rights>Copyright © 1982 American Cancer Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c4499-58ee6d5ea984043434a52dfd552e28f617e776545947e0c159316c4fea006cc13</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6124312$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Saito, Haruhiko</creatorcontrib><creatorcontrib>Saito, Shiro</creatorcontrib><creatorcontrib>Sano, Toshiaki</creatorcontrib><creatorcontrib>Kagawa, Noriko</creatorcontrib><creatorcontrib>Hizawa, Kazuo</creatorcontrib><creatorcontrib>Tatara, Kiyoshi</creatorcontrib><title>Immunoreactive somatostatin in catecholamine‐producing extra‐adrenal paraganglioma</title><title>Cancer</title><addtitle>Cancer</addtitle><description>A patient with catecholamine‐producing extra‐adrenal paraganglioma was found to have a high concentration of immunoreactive somatostatin (IR‐SRIF) in the peripheral blood plasma (47.0 pg/ml, normal; 13.3 ± 5.3 pg/ml, mean ± SD). After removal of the tumor, the plasma SRIF level fell within normal range (8.7 pg/ml). In the resected tumor, a considerable amount of IR‐SRIF (71.0 ng/g wet weight) was also detected and SRIF‐positive tumor cells were demonstrated by the immunoperoxidase technique. Chromatographic analysis of an extract of the tumor showed the presence of two IR‐SRIF components of large molecular size besides a component consistent with authentic tetradecapeptide SRIF (SRIF 14), and one of these had the same molecular size as octacosapeptide SRIF (SRIF 28). This seems to be the first report of a catecholamine‐producing extra‐adrenal paraganglioma that produces IR‐SRIF with molecular heterogeneity.</description><subject>Adrenal Gland Neoplasms - metabolism</subject><subject>Adult</subject><subject>Epinephrine - blood</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Norepinephrine - blood</subject><subject>Paraganglioma - metabolism</subject><subject>Paraganglioma - pathology</subject><subject>Paraganglioma - surgery</subject><subject>Radioimmunoassay</subject><subject>Somatostatin - blood</subject><issn>0008-543X</issn><issn>1097-0142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkNuKFDEQhoMo67j6CMJciV70WDn1YRRhbU8NiwOiIt4UZbp6bOnDmHSre-cj-Iw-iRlmXNALQRIIyVf5q_iEeCxhJQHUfQlFloA06q4scgU5yHsW1vqhTWG9PqueJOXL8pWKxAJoVTzSK1iVmwcqqa6IxeXnq2IBAHlijX53XdwI4VO8ZsrqE3GSSmW0VAvxtur7eRg9k5vaL7wMY0_TGCaa2mEZt6OJ3cexo74d-Of3Hzs_1rNrh-2Sv02e4gvVngfqljvytKVh27Ux4qa41lAX-NbxPBVvnj19Xb5IzjfPq_LsPHHGFEVic-a0tkxFbsDouMiquqmtVazyJpUZZ1lqjS1MxuCkLbRMnWmYAFLnpD4Vdw65ca7PM4cJ-zY47joaeJwDZkZKBQpi4ftDofNjCJ4b3Pm2J3-BEnAvHffecO8Nf0tHC6gxSkeM0vFP6ZEAlhtUWMXw28cp5g8915fRR8uR84F_bTu--K_O_2z8F9G_AMRjoW8</recordid><startdate>19820801</startdate><enddate>19820801</enddate><creator>Saito, Haruhiko</creator><creator>Saito, Shiro</creator><creator>Sano, Toshiaki</creator><creator>Kagawa, Noriko</creator><creator>Hizawa, Kazuo</creator><creator>Tatara, Kiyoshi</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19820801</creationdate><title>Immunoreactive somatostatin in catecholamine‐producing extra‐adrenal paraganglioma</title><author>Saito, Haruhiko ; Saito, Shiro ; Sano, Toshiaki ; Kagawa, Noriko ; Hizawa, Kazuo ; Tatara, Kiyoshi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4499-58ee6d5ea984043434a52dfd552e28f617e776545947e0c159316c4fea006cc13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adrenal Gland Neoplasms - metabolism</topic><topic>Adult</topic><topic>Epinephrine - blood</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Norepinephrine - blood</topic><topic>Paraganglioma - metabolism</topic><topic>Paraganglioma - pathology</topic><topic>Paraganglioma - surgery</topic><topic>Radioimmunoassay</topic><topic>Somatostatin - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Saito, Haruhiko</creatorcontrib><creatorcontrib>Saito, Shiro</creatorcontrib><creatorcontrib>Sano, Toshiaki</creatorcontrib><creatorcontrib>Kagawa, Noriko</creatorcontrib><creatorcontrib>Hizawa, Kazuo</creatorcontrib><creatorcontrib>Tatara, Kiyoshi</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Saito, Haruhiko</au><au>Saito, Shiro</au><au>Sano, Toshiaki</au><au>Kagawa, Noriko</au><au>Hizawa, Kazuo</au><au>Tatara, Kiyoshi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoreactive somatostatin in catecholamine‐producing extra‐adrenal paraganglioma</atitle><jtitle>Cancer</jtitle><addtitle>Cancer</addtitle><date>1982-08-01</date><risdate>1982</risdate><volume>50</volume><issue>3</issue><spage>560</spage><epage>565</epage><pages>560-565</pages><issn>0008-543X</issn><eissn>1097-0142</eissn><abstract>A patient with catecholamine‐producing extra‐adrenal paraganglioma was found to have a high concentration of immunoreactive somatostatin (IR‐SRIF) in the peripheral blood plasma (47.0 pg/ml, normal; 13.3 ± 5.3 pg/ml, mean ± SD). After removal of the tumor, the plasma SRIF level fell within normal range (8.7 pg/ml). In the resected tumor, a considerable amount of IR‐SRIF (71.0 ng/g wet weight) was also detected and SRIF‐positive tumor cells were demonstrated by the immunoperoxidase technique. Chromatographic analysis of an extract of the tumor showed the presence of two IR‐SRIF components of large molecular size besides a component consistent with authentic tetradecapeptide SRIF (SRIF 14), and one of these had the same molecular size as octacosapeptide SRIF (SRIF 28). This seems to be the first report of a catecholamine‐producing extra‐adrenal paraganglioma that produces IR‐SRIF with molecular heterogeneity.</abstract><cop>New York</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>6124312</pmid><doi>10.1002/1097-0142(19820801)50:3<560::AID-CNCR2820500329>3.0.CO;2-I</doi><tpages>6</tpages></addata></record>
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subjects	Adrenal Gland Neoplasms - metabolism Adult Epinephrine - blood Female Humans Immunoenzyme Techniques Norepinephrine - blood Paraganglioma - metabolism Paraganglioma - pathology Paraganglioma - surgery Radioimmunoassay Somatostatin - blood
title	Immunoreactive somatostatin in catecholamine‐producing extra‐adrenal paraganglioma
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