Exercise-induced left ventricular dysfunction in symptomatic and asymptomatic patients with aortic regurgitation: Assessment with radionuclide cineangiography
In patients with aortic regurgitation, left ventricular dysfunction at rest, which is associated with a poor long-term prognosis, often develops before severe symptoms. To determine whether evidence of left ventricular dysfunction could be detected before if appeared at rest, 43 patients with severe...
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| Veröffentlicht in: | The American journal of cardiology 1978-09, Vol.42 (3), p.351-357 |
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| container_title | The American journal of cardiology |
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| creator | Borer, Jeffrey S. Bacharach, Stephen L. Green, Michael V. Kent, Kenneth M. Henry, Walter L. Rosing, Douglas R. Seides, Stuart F. Johnston, Gerald S. Epstein, Stephen E. |
| description | In patients with aortic regurgitation, left ventricular dysfunction at rest, which is associated with a poor long-term prognosis, often develops before severe symptoms. To determine whether evidence of left ventricular dysfunction could be detected before if appeared at rest, 43 patients with severe aortic regurgitation were studied using radionuclide cineanglography during exercise. In 30 normal subjects, left ventricular ejection fraction increased during exercise (57 ± 1 percent [mean ± standard error] at rest, 71 ± 2 percent during exercise,
P < 0.001). In contrast, among 21
symptomatic patients, ejection fraction was normal at rest in 14 patients (average 47 ± 2 percent) but normal during exercise in only one patient (average 38 ± 2 percent,
P < 0.001). Ejection fraction was normal at rest in 21 of 22
asymptomatic patients (average 62 ± 2 percent) but was normal during exercise in only 13 (average 57 ± 3 percent,
P < 0.001). Thus, exercise-induced left ventricular dysfunction can precede symptoms and dysfunction at rest. Radionuclide assessment of left ventricular function during exercise may prove valuable in sequentially following the state of left ventricular function in patients before the onset of symptoms or of irreversible left ventricular failure. |
| doi_str_mv | 10.1016/0002-9149(78)90927-X |
| format | Article |
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P < 0.001). In contrast, among 21
symptomatic patients, ejection fraction was normal at rest in 14 patients (average 47 ± 2 percent) but normal during exercise in only one patient (average 38 ± 2 percent,
P < 0.001). Ejection fraction was normal at rest in 21 of 22
asymptomatic patients (average 62 ± 2 percent) but was normal during exercise in only 13 (average 57 ± 3 percent,
P < 0.001). Thus, exercise-induced left ventricular dysfunction can precede symptoms and dysfunction at rest. Radionuclide assessment of left ventricular function during exercise may prove valuable in sequentially following the state of left ventricular function in patients before the onset of symptoms or of irreversible left ventricular failure.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/0002-9149(78)90927-X</identifier><identifier>PMID: 685847</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adolescent ; Adult ; Aged ; Aortic Valve Insufficiency - diagnostic imaging ; Aortic Valve Insufficiency - physiopathology ; Blood Pressure ; Cardiac Catheterization ; Cardiac Volume ; Electrocardiography ; Female ; Heart Ventricles - diagnostic imaging ; Heart Ventricles - physiopathology ; Humans ; Male ; Middle Aged ; Myocardial Contraction ; Physical Exertion ; Prognosis ; Radionuclide Imaging ; Technetium</subject><ispartof>The American journal of cardiology, 1978-09, Vol.42 (3), p.351-357</ispartof><rights>1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-8a18fd2be3fafb525c58c9db102f93ade24d2a48ba4b3be372e8b1581443b82a3</citedby><cites>FETCH-LOGICAL-c356t-8a18fd2be3fafb525c58c9db102f93ade24d2a48ba4b3be372e8b1581443b82a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/000291497890927X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/685847$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Borer, Jeffrey S.</creatorcontrib><creatorcontrib>Bacharach, Stephen L.</creatorcontrib><creatorcontrib>Green, Michael V.</creatorcontrib><creatorcontrib>Kent, Kenneth M.</creatorcontrib><creatorcontrib>Henry, Walter L.</creatorcontrib><creatorcontrib>Rosing, Douglas R.</creatorcontrib><creatorcontrib>Seides, Stuart F.</creatorcontrib><creatorcontrib>Johnston, Gerald S.</creatorcontrib><creatorcontrib>Epstein, Stephen E.</creatorcontrib><title>Exercise-induced left ventricular dysfunction in symptomatic and asymptomatic patients with aortic regurgitation: Assessment with radionuclide cineangiography</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>In patients with aortic regurgitation, left ventricular dysfunction at rest, which is associated with a poor long-term prognosis, often develops before severe symptoms. To determine whether evidence of left ventricular dysfunction could be detected before if appeared at rest, 43 patients with severe aortic regurgitation were studied using radionuclide cineanglography during exercise. In 30 normal subjects, left ventricular ejection fraction increased during exercise (57 ± 1 percent [mean ± standard error] at rest, 71 ± 2 percent during exercise,
P < 0.001). In contrast, among 21
symptomatic patients, ejection fraction was normal at rest in 14 patients (average 47 ± 2 percent) but normal during exercise in only one patient (average 38 ± 2 percent,
P < 0.001). Ejection fraction was normal at rest in 21 of 22
asymptomatic patients (average 62 ± 2 percent) but was normal during exercise in only 13 (average 57 ± 3 percent,
P < 0.001). Thus, exercise-induced left ventricular dysfunction can precede symptoms and dysfunction at rest. Radionuclide assessment of left ventricular function during exercise may prove valuable in sequentially following the state of left ventricular function in patients before the onset of symptoms or of irreversible left ventricular failure.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aortic Valve Insufficiency - diagnostic imaging</subject><subject>Aortic Valve Insufficiency - physiopathology</subject><subject>Blood Pressure</subject><subject>Cardiac Catheterization</subject><subject>Cardiac Volume</subject><subject>Electrocardiography</subject><subject>Female</subject><subject>Heart Ventricles - diagnostic imaging</subject><subject>Heart Ventricles - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Contraction</subject><subject>Physical Exertion</subject><subject>Prognosis</subject><subject>Radionuclide Imaging</subject><subject>Technetium</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1u1TAQhS3E36XwBl14hegi1HacxGGBVFUtrVSJTZG6syb25NYocYLtFO7L8Kw4pKpYsbHlM98cyecQcszZR854fcoYE0XLZfuhUScta0VT3D0jO66atuAtL5-T3RPymryJ8Xt-cl7Vr8jLWlVKNjvy--IXBuMiFs7bxaClA_aJPqBPwZllgEDtIfaLN8lNnjpP42Gc0zRCcoaCtxT-FeZ85tVIf7p0T2EKqxhwv4S9S7BafKJnMWKMY8Y2KoDN-mIGZ5Ea5xH83k37APP94S150cMQ8d3jfUS-XV7cnl8VN1-_XJ-f3RSmrOpUKOCqt6LDsoe-q0RlKmVa23Em-rYEi0JaAVJ1ILsyU41A1fFKcSnLTgkoj8j7zXcO048FY9KjiwaHATxOS9SN5Kyqa55BuYEmTDEG7PUc3AjhoDnTayt6jVyvketG6b-t6Lu8dvzov3Qj2qelrYY8_ryNMf_xwWHQ0eQccx0uoEnaTu7__n8A3wOitg</recordid><startdate>197809</startdate><enddate>197809</enddate><creator>Borer, Jeffrey S.</creator><creator>Bacharach, Stephen L.</creator><creator>Green, Michael V.</creator><creator>Kent, Kenneth M.</creator><creator>Henry, Walter L.</creator><creator>Rosing, Douglas R.</creator><creator>Seides, Stuart F.</creator><creator>Johnston, Gerald S.</creator><creator>Epstein, Stephen E.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197809</creationdate><title>Exercise-induced left ventricular dysfunction in symptomatic and asymptomatic patients with aortic regurgitation: Assessment with radionuclide cineangiography</title><author>Borer, Jeffrey S. ; Bacharach, Stephen L. ; Green, Michael V. ; Kent, Kenneth M. ; Henry, Walter L. ; Rosing, Douglas R. ; Seides, Stuart F. ; Johnston, Gerald S. ; Epstein, Stephen E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-8a18fd2be3fafb525c58c9db102f93ade24d2a48ba4b3be372e8b1581443b82a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aortic Valve Insufficiency - diagnostic imaging</topic><topic>Aortic Valve Insufficiency - physiopathology</topic><topic>Blood Pressure</topic><topic>Cardiac Catheterization</topic><topic>Cardiac Volume</topic><topic>Electrocardiography</topic><topic>Female</topic><topic>Heart Ventricles - diagnostic imaging</topic><topic>Heart Ventricles - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Contraction</topic><topic>Physical Exertion</topic><topic>Prognosis</topic><topic>Radionuclide Imaging</topic><topic>Technetium</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Borer, Jeffrey S.</creatorcontrib><creatorcontrib>Bacharach, Stephen L.</creatorcontrib><creatorcontrib>Green, Michael V.</creatorcontrib><creatorcontrib>Kent, Kenneth M.</creatorcontrib><creatorcontrib>Henry, Walter L.</creatorcontrib><creatorcontrib>Rosing, Douglas R.</creatorcontrib><creatorcontrib>Seides, Stuart F.</creatorcontrib><creatorcontrib>Johnston, Gerald S.</creatorcontrib><creatorcontrib>Epstein, Stephen E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Borer, Jeffrey S.</au><au>Bacharach, Stephen L.</au><au>Green, Michael V.</au><au>Kent, Kenneth M.</au><au>Henry, Walter L.</au><au>Rosing, Douglas R.</au><au>Seides, Stuart F.</au><au>Johnston, Gerald S.</au><au>Epstein, Stephen E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exercise-induced left ventricular dysfunction in symptomatic and asymptomatic patients with aortic regurgitation: Assessment with radionuclide cineangiography</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1978-09</date><risdate>1978</risdate><volume>42</volume><issue>3</issue><spage>351</spage><epage>357</epage><pages>351-357</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>In patients with aortic regurgitation, left ventricular dysfunction at rest, which is associated with a poor long-term prognosis, often develops before severe symptoms. To determine whether evidence of left ventricular dysfunction could be detected before if appeared at rest, 43 patients with severe aortic regurgitation were studied using radionuclide cineanglography during exercise. In 30 normal subjects, left ventricular ejection fraction increased during exercise (57 ± 1 percent [mean ± standard error] at rest, 71 ± 2 percent during exercise,
P < 0.001). In contrast, among 21
symptomatic patients, ejection fraction was normal at rest in 14 patients (average 47 ± 2 percent) but normal during exercise in only one patient (average 38 ± 2 percent,
P < 0.001). Ejection fraction was normal at rest in 21 of 22
asymptomatic patients (average 62 ± 2 percent) but was normal during exercise in only 13 (average 57 ± 3 percent,
P < 0.001). Thus, exercise-induced left ventricular dysfunction can precede symptoms and dysfunction at rest. Radionuclide assessment of left ventricular function during exercise may prove valuable in sequentially following the state of left ventricular function in patients before the onset of symptoms or of irreversible left ventricular failure.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>685847</pmid><doi>10.1016/0002-9149(78)90927-X</doi><tpages>7</tpages></addata></record> |
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| ispartof | The American journal of cardiology, 1978-09, Vol.42 (3), p.351-357 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent Adult Aged Aortic Valve Insufficiency - diagnostic imaging Aortic Valve Insufficiency - physiopathology Blood Pressure Cardiac Catheterization Cardiac Volume Electrocardiography Female Heart Ventricles - diagnostic imaging Heart Ventricles - physiopathology Humans Male Middle Aged Myocardial Contraction Physical Exertion Prognosis Radionuclide Imaging Technetium |
| title | Exercise-induced left ventricular dysfunction in symptomatic and asymptomatic patients with aortic regurgitation: Assessment with radionuclide cineangiography |
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