A partial characterization of suppressor cells in rat fetal liver cells
Rat fetal liver cells (FLC) obtained at 18–20 days gestation suppressed mixed lymphocyte reactions(MLR) of adult lymph node cells. The suppression was not strain specific: both syngeneic and allogeneic FLC were capable of suppressing the MLR. The same suppressor activity was observed with fetal sple...
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| Veröffentlicht in: | Cellular immunology 1982-03, Vol.68 (1), p.16-24 |
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| container_title | Cellular immunology |
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| creator | Monden, Morito Staruch, Andrea J. Fortner, Joseph G. |
| description | Rat fetal liver cells (FLC) obtained at 18–20 days gestation suppressed mixed lymphocyte reactions(MLR) of adult lymph node cells. The suppression was not strain specific: both syngeneic and allogeneic FLC were capable of suppressing the MLR. The same suppressor activity was observed with fetal spleen cells but not with fetal thymus cells. Removal of phagocytic cells from FLC failed to inhibit the suppressor activity. The suppressor cells were separated into two different types by BSA density gradient: one is radiosensitive, the other radioresistant. A stronger suppressor activity was observed in radiosensitive cells. The suppressor cells belonged to the fraction agglutinated with peanut agglutinin. The data suggest that the suppressor cells in rat FLC may be a proliferating blastoid-type cell rather than mature lymphocytes or mature macrophages. |
| doi_str_mv | 10.1016/0008-8749(82)90086-7 |
| format | Article |
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The suppression was not strain specific: both syngeneic and allogeneic FLC were capable of suppressing the MLR. The same suppressor activity was observed with fetal spleen cells but not with fetal thymus cells. Removal of phagocytic cells from FLC failed to inhibit the suppressor activity. The suppressor cells were separated into two different types by BSA density gradient: one is radiosensitive, the other radioresistant. A stronger suppressor activity was observed in radiosensitive cells. The suppressor cells belonged to the fraction agglutinated with peanut agglutinin. The data suggest that the suppressor cells in rat FLC may be a proliferating blastoid-type cell rather than mature lymphocytes or mature macrophages.</description><identifier>ISSN: 0008-8749</identifier><identifier>EISSN: 1090-2163</identifier><identifier>DOI: 10.1016/0008-8749(82)90086-7</identifier><identifier>PMID: 6211250</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Cell Separation - methods ; Female ; Fetus - immunology ; In Vitro Techniques ; Liver - immunology ; Lymph Nodes - immunology ; Lymphocyte Culture Test, Mixed ; Male ; Pregnancy ; Radiation Tolerance ; Rats ; Rats, Inbred ACI ; T-Lymphocytes, Regulatory - immunology ; T-Lymphocytes, Regulatory - radiation effects</subject><ispartof>Cellular immunology, 1982-03, Vol.68 (1), p.16-24</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c306t-608ffa71ab230810721899c485f77ff7c2ee1208aa41e52895eb9f8b0b13f4b63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0008874982900867$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6211250$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Monden, Morito</creatorcontrib><creatorcontrib>Staruch, Andrea J.</creatorcontrib><creatorcontrib>Fortner, Joseph G.</creatorcontrib><title>A partial characterization of suppressor cells in rat fetal liver cells</title><title>Cellular immunology</title><addtitle>Cell Immunol</addtitle><description>Rat fetal liver cells (FLC) obtained at 18–20 days gestation suppressed mixed lymphocyte reactions(MLR) of adult lymph node cells. The suppression was not strain specific: both syngeneic and allogeneic FLC were capable of suppressing the MLR. The same suppressor activity was observed with fetal spleen cells but not with fetal thymus cells. Removal of phagocytic cells from FLC failed to inhibit the suppressor activity. The suppressor cells were separated into two different types by BSA density gradient: one is radiosensitive, the other radioresistant. A stronger suppressor activity was observed in radiosensitive cells. The suppressor cells belonged to the fraction agglutinated with peanut agglutinin. The data suggest that the suppressor cells in rat FLC may be a proliferating blastoid-type cell rather than mature lymphocytes or mature macrophages.</description><subject>Animals</subject><subject>Cell Separation - methods</subject><subject>Female</subject><subject>Fetus - immunology</subject><subject>In Vitro Techniques</subject><subject>Liver - immunology</subject><subject>Lymph Nodes - immunology</subject><subject>Lymphocyte Culture Test, Mixed</subject><subject>Male</subject><subject>Pregnancy</subject><subject>Radiation Tolerance</subject><subject>Rats</subject><subject>Rats, Inbred ACI</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>T-Lymphocytes, Regulatory - radiation effects</subject><issn>0008-8749</issn><issn>1090-2163</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1Lw0AQhhdRaq3-A4WcRA_Rmc3Hbi5CKVqFghc9L5vtLK6kTdxNCvrrTWzo0dMwvO87Hw9jlwh3CJjfA4CMpUiLG8lvi77JY3HEpggFxBzz5JhND5ZTdhbCJwBiWsCETXKOyDOYsuU8arRvna4i86G9Ni1596NbV2-j2kahaxpPIdQ-MlRVIXLbyOs2stT2icrtaBTO2YnVVaCLsc7Y-9Pj2-I5Xr0uXxbzVWwSyNs4B2mtFqhLnoBEEBxlUZhUZlYIa4XhRMhBap0iZVwWGZWFlSWUmNi0zJMZu97PbXz91VFo1caF4QK9pboLSqQIWZZnvTHdG42vQ_BkVePdRvtvhaAGfmqAowY4SnL1x0-JPnY1zu_KDa0PoRFYrz_sdeqf3DnyKhhHW0Nr58m0al27_xf8AoLGfnU</recordid><startdate>19820315</startdate><enddate>19820315</enddate><creator>Monden, Morito</creator><creator>Staruch, Andrea J.</creator><creator>Fortner, Joseph G.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19820315</creationdate><title>A partial characterization of suppressor cells in rat fetal liver cells</title><author>Monden, Morito ; Staruch, Andrea J. ; Fortner, Joseph G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c306t-608ffa71ab230810721899c485f77ff7c2ee1208aa41e52895eb9f8b0b13f4b63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Cell Separation - methods</topic><topic>Female</topic><topic>Fetus - immunology</topic><topic>In Vitro Techniques</topic><topic>Liver - immunology</topic><topic>Lymph Nodes - immunology</topic><topic>Lymphocyte Culture Test, Mixed</topic><topic>Male</topic><topic>Pregnancy</topic><topic>Radiation Tolerance</topic><topic>Rats</topic><topic>Rats, Inbred ACI</topic><topic>T-Lymphocytes, Regulatory - immunology</topic><topic>T-Lymphocytes, Regulatory - radiation effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Monden, Morito</creatorcontrib><creatorcontrib>Staruch, Andrea J.</creatorcontrib><creatorcontrib>Fortner, Joseph G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Cellular immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Monden, Morito</au><au>Staruch, Andrea J.</au><au>Fortner, Joseph G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A partial characterization of suppressor cells in rat fetal liver cells</atitle><jtitle>Cellular immunology</jtitle><addtitle>Cell Immunol</addtitle><date>1982-03-15</date><risdate>1982</risdate><volume>68</volume><issue>1</issue><spage>16</spage><epage>24</epage><pages>16-24</pages><issn>0008-8749</issn><eissn>1090-2163</eissn><abstract>Rat fetal liver cells (FLC) obtained at 18–20 days gestation suppressed mixed lymphocyte reactions(MLR) of adult lymph node cells. The suppression was not strain specific: both syngeneic and allogeneic FLC were capable of suppressing the MLR. The same suppressor activity was observed with fetal spleen cells but not with fetal thymus cells. Removal of phagocytic cells from FLC failed to inhibit the suppressor activity. The suppressor cells were separated into two different types by BSA density gradient: one is radiosensitive, the other radioresistant. A stronger suppressor activity was observed in radiosensitive cells. The suppressor cells belonged to the fraction agglutinated with peanut agglutinin. The data suggest that the suppressor cells in rat FLC may be a proliferating blastoid-type cell rather than mature lymphocytes or mature macrophages.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>6211250</pmid><doi>10.1016/0008-8749(82)90086-7</doi><tpages>9</tpages></addata></record> |
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| ispartof | Cellular immunology, 1982-03, Vol.68 (1), p.16-24 |
| issn | 0008-8749 1090-2163 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Cell Separation - methods Female Fetus - immunology In Vitro Techniques Liver - immunology Lymph Nodes - immunology Lymphocyte Culture Test, Mixed Male Pregnancy Radiation Tolerance Rats Rats, Inbred ACI T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - radiation effects |
| title | A partial characterization of suppressor cells in rat fetal liver cells |
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