Prostate specific acid phosphatase: further studies with immunological techniques
In the continuing saga of examining new immunological methods for the measurement of prostate-specific acid phosphatase (PAcP), we have compared the new technique of immunoenzymatic assay (IEA) to radioimmunoassay (RIA). No marked advantages in either the early diagnosis or the follow-up of prostati...
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| Veröffentlicht in: | Clinica chimica acta 1982-06, Vol.122 (1), p.29-38 |
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| creator | Davies, Sally N. Griffiths, John C. |
| description | In the continuing saga of examining new immunological methods for the measurement of prostate-specific acid phosphatase (PAcP), we have compared the new technique of immunoenzymatic assay (IEA) to radioimmunoassay (RIA). No marked advantages in either the early diagnosis or the follow-up of prostatic cancer were apparent, with comparable specificities and sensitivities for both methods. The simple procedure, inexpensive equipment and stable reagents needed for the IEA were its major advantages. A comparison with digital rectal examination suggests that until the 'at risk' population is screened regularly by a PAcP assay, the most appropriate use of the assay is monitoring treatment effectivity. |
| doi_str_mv | 10.1016/0009-8981(82)90091-2 |
| format | Article |
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No marked advantages in either the early diagnosis or the follow-up of prostatic cancer were apparent, with comparable specificities and sensitivities for both methods. The simple procedure, inexpensive equipment and stable reagents needed for the IEA were its major advantages. 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A comparison with digital rectal examination suggests that until the 'at risk' population is screened regularly by a PAcP assay, the most appropriate use of the assay is monitoring treatment effectivity.</description><subject>Acid Phosphatase - analysis</subject><subject>Adenocarcinoma - enzymology</subject><subject>Adult</subject><subject>Aged</subject><subject>False Positive Reactions</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Prostate - enzymology</subject><subject>Prostatectomy</subject><subject>Prostatic Hyperplasia - enzymology</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - drug therapy</subject><subject>Prostatic Neoplasms - enzymology</subject><subject>Radioimmunoassay</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMo67r6DRRyEj1Uk6ZpUg-CLP6DBRX0HLLJ1EbabU1SxW9v6y579DQ85r0Z3g-hY0ouKKH5JSGkSGQh6ZlMz4tB0CTdQVMqBUtYVqS7aLq17KODED4GmZGcTtAkp0JyJqfo5dm3IeoIOHRgXOkM1sZZ3FVt6CoddYArXPY-VuBxiL11EPC3ixV2TdOv2rp9d0bXOIKpVu6zh3CI9kpdBzjazBl6u7t9nT8ki6f7x_nNIjGMi5gUppBSS851biUnxBCba2sNp1RqkknKhC7zcsmAg2BQWkIFJzTNQQpjjWYzdLq-2_l2_BtV44KButYraPugREYJJ6IYjNnaaIaqwUOpOu8a7X8UJWokqUZMasSkZKr-SKp0iJ1s7vfLBuw2tEE37K_XexhKfjnwKhgHKwPWeTBR2db9_-AXUqKDxQ</recordid><startdate>19820616</startdate><enddate>19820616</enddate><creator>Davies, Sally N.</creator><creator>Griffiths, John C.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19820616</creationdate><title>Prostate specific acid phosphatase: further studies with immunological techniques</title><author>Davies, Sally N. ; Griffiths, John C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-9c988a855a6d8500c0d6addc5118a048137af6fb3e5e73efd01750126e87cdca3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Acid Phosphatase - analysis</topic><topic>Adenocarcinoma - enzymology</topic><topic>Adult</topic><topic>Aged</topic><topic>False Positive Reactions</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Prostate - enzymology</topic><topic>Prostatectomy</topic><topic>Prostatic Hyperplasia - enzymology</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Prostatic Neoplasms - drug therapy</topic><topic>Prostatic Neoplasms - enzymology</topic><topic>Radioimmunoassay</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Davies, Sally N.</creatorcontrib><creatorcontrib>Griffiths, John C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Davies, Sally N.</au><au>Griffiths, John C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prostate specific acid phosphatase: further studies with immunological techniques</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>1982-06-16</date><risdate>1982</risdate><volume>122</volume><issue>1</issue><spage>29</spage><epage>38</epage><pages>29-38</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>In the continuing saga of examining new immunological methods for the measurement of prostate-specific acid phosphatase (PAcP), we have compared the new technique of immunoenzymatic assay (IEA) to radioimmunoassay (RIA). 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| ispartof | Clinica chimica acta, 1982-06, Vol.122 (1), p.29-38 |
| issn | 0009-8981 1873-3492 |
| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier) |
| subjects | Acid Phosphatase - analysis Adenocarcinoma - enzymology Adult Aged False Positive Reactions Female Humans Immunoenzyme Techniques Male Middle Aged Prostate - enzymology Prostatectomy Prostatic Hyperplasia - enzymology Prostatic Neoplasms - diagnosis Prostatic Neoplasms - drug therapy Prostatic Neoplasms - enzymology Radioimmunoassay |
| title | Prostate specific acid phosphatase: further studies with immunological techniques |
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