Studies of the cytosol 3α-hydroxysteroid dehydrogenase of human prostatic tissue: Comparison of enzyme activities in hyperplastic, malignant and normal tissues

The conversion of dihydrotestosterone (DHT) to 3α-androstanediol (3α-Adiol) was studied using the cytosol fractions of hyperplastic [20], malignant [15] and normal [1] human prostatic tissues. Standard assay conditions for the 3α-hydroxysteroid dehydrogenase in hyperplastic tissue were: 0.5 μM DHT,...

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Veröffentlicht in:	Journal of steroid biochemistry 1982-03, Vol.16 (3), p.373-377
1. Verfasser:	Hudson, Robert W.
Format:	Artikel
Sprache:	eng
Schlagworte:	3-alpha-Hydroxysteroid Dehydrogenase (B-Specific) 3-Hydroxysteroid Dehydrogenases - metabolism Adult Androstanols - metabolism Cytosol - enzymology Dihydrotestosterone - metabolism Humans Hydrogen-Ion Concentration Male Prostate - enzymology Prostatic Hyperplasia - enzymology Prostatic Neoplasms - enzymology Subcellular Fractions - enzymology
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