The use of crystallography, graphics, and quantitative structure-activity relationships in the analysis of the papain hydrolysis of X-phenyl hippurates

The effect of 3- and 4-monosubstitution and 3,5-disubstitution on the phenyl leaving group of the papain-catalyzed hydrolysis of 27 phenyl hippurates is reported. The Michaelis-Menten constant ( K m ) at 25.0 °C and pH 6.0 was determined for the substrates and, in addition, the first-order rate cons...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Archives of biochemistry and biophysics 1982-04, Vol.215 (1), p.319-328
Hauptverfasser:	Smith, R.Nelson, Hansch, Corwin, Kim, Ki Hwan, Omiya, Bruce, Fukumura, Glen, Selassie, Cynthia Dias, Jow, Priscilla Y.C., Blaney, Jeffrey M., Langridge, Robert
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Sites Chemical Phenomena Chemistry Hippurates Hydrolysis Kinetics Models, Chemical Models, Molecular Papain Protein Binding Structure-Activity Relationship X-Ray Diffraction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!