Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts

To identify the role of the myocardial β-adrenergic pathway in congestive heart failure, we examined β-adrenergic-receptor density, adenylate cyclase and creatine kinase activities, muscle contraction in vitro, and myocardial contractile protein levels in the left ventricles of failing and normally...

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Veröffentlicht in:	The New England journal of medicine 1982-07, Vol.307 (4), p.205-211
Hauptverfasser:	Bristow, Michael R, Ginsburg, Robert, Minobe, Wayne, Cubicciotti, Roger S, Sageman, W. Scott, Lurie, Keith, Billingham, Margaret E, Harrison, Donald C, Stinson, Edward B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylyl Cyclases - analysis Adolescent Adult Catecholamines - pharmacology Contractile Proteins - analysis Creatine Kinase - analysis Dihydroalprenolol - metabolism Female Fluorides - pharmacology Heart Failure - physiopathology Histamine - pharmacology Humans Hydroxyproline - analysis In Vitro Techniques Isoproterenol - pharmacology Male Middle Aged Myocardial Contraction - drug effects Myocardium - analysis Radioligand Assay Receptors, Adrenergic - analysis Receptors, Adrenergic, beta - analysis Tritium
Online-Zugang:	Volltext
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