Detection and characterization of the intermediate on the folding pathway of human .alpha.-lactalbumin

To discuss the relation between the folding mechanism and the chemical structure of proteins, the reversible unfolding reactions of human alpha-lactalbumin by acidification and by guanidine hydrochloride at 25 degrees C are studied by means of circular dichroism, difference spectra and pH-jump measu...

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Veröffentlicht in:	Biochemistry (Easton) 1978-09, Vol.17 (18), p.3753-3758
Hauptverfasser:	Nozaka, Makoto, Kuwajima, Kunihiro, Nitta, Katsutoshi, Sugai, Shintaro
Format:	Artikel
Sprache:	eng
Schlagworte:	Circular Dichroism Guanidines Humans Kinetics Lactalbumin Protein Conformation Spectrophotometry, Ultraviolet Thermodynamics
Online-Zugang:	Volltext
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