Ovine placental lactogen stimulation of ornithine decarboxylase activity in brain and liver of neonatal rats
Ovine placental lactogen (oPL), growth hormone (oGH), prolactin (oPRL) and human placental lactogen (hPL) were administered intracisternally (ic) or intraperitoneally (ip) to 17 day old rats and brain and liver ODC activities determined four hours later. When given ic, oPL, oGH and oPRL caused signi...
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| Veröffentlicht in: | Life sciences (1973) 1978-06, Vol.22 (23), p.2073-2078 |
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| container_end_page | 2078 |
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| container_issue | 23 |
| container_start_page | 2073 |
| container_title | Life sciences (1973) |
| container_volume | 22 |
| creator | Butler, S.R. Hurley, T.W. Schanberg, S.M. Handwerger, S. |
| description | Ovine placental lactogen (oPL), growth hormone (oGH), prolactin (oPRL) and human placental lactogen (hPL) were administered intracisternally (ic) or intraperitoneally (ip) to 17 day old rats and brain and liver ODC activities determined four hours later. When given ic, oPL, oGH and oPRL caused significant increases in brain ODC activity, while hPL had no significant effect. After ip administration, oPL and oGH also caused a significant increase in brain as well as liver ODC activity but oPRL and hPL were without significant effect. The stimulation of polyamine metabolism by oPL together with earlier reports of its potent somatotropic effects and its high concentration in the fetus supports the hypothesis that oPL may be important in the regulation of fetal growth. |
| doi_str_mv | 10.1016/0024-3205(78)90450-2 |
| format | Article |
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When given ic, oPL, oGH and oPRL caused significant increases in brain ODC activity, while hPL had no significant effect. After ip administration, oPL and oGH also caused a significant increase in brain as well as liver ODC activity but oPRL and hPL were without significant effect. The stimulation of polyamine metabolism by oPL together with earlier reports of its potent somatotropic effects and its high concentration in the fetus supports the hypothesis that oPL may be important in the regulation of fetal growth.</description><identifier>ISSN: 0024-3205</identifier><identifier>EISSN: 1879-0631</identifier><identifier>DOI: 10.1016/0024-3205(78)90450-2</identifier><identifier>PMID: 672447</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Animals ; Animals, Newborn - metabolism ; Brain - drug effects ; Brain - enzymology ; Carboxy-Lyases - metabolism ; Growth Hormone - pharmacology ; Humans ; Liver - drug effects ; Liver - enzymology ; Ornithine Decarboxylase - metabolism ; Placental Lactogen - pharmacology ; Prolactin - pharmacology ; Rats ; Sheep ; Stimulation, Chemical</subject><ispartof>Life sciences (1973), 1978-06, Vol.22 (23), p.2073-2078</ispartof><rights>1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-42fbd5d35434631d6d8d171e74e8117d85b8de0945c2fd05afe80ebcef5ceeaa3</citedby><cites>FETCH-LOGICAL-c356t-42fbd5d35434631d6d8d171e74e8117d85b8de0945c2fd05afe80ebcef5ceeaa3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0024320578904502$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/672447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Butler, S.R.</creatorcontrib><creatorcontrib>Hurley, T.W.</creatorcontrib><creatorcontrib>Schanberg, S.M.</creatorcontrib><creatorcontrib>Handwerger, S.</creatorcontrib><title>Ovine placental lactogen stimulation of ornithine decarboxylase activity in brain and liver of neonatal rats</title><title>Life sciences (1973)</title><addtitle>Life Sci</addtitle><description>Ovine placental lactogen (oPL), growth hormone (oGH), prolactin (oPRL) and human placental lactogen (hPL) were administered intracisternally (ic) or intraperitoneally (ip) to 17 day old rats and brain and liver ODC activities determined four hours later. When given ic, oPL, oGH and oPRL caused significant increases in brain ODC activity, while hPL had no significant effect. After ip administration, oPL and oGH also caused a significant increase in brain as well as liver ODC activity but oPRL and hPL were without significant effect. The stimulation of polyamine metabolism by oPL together with earlier reports of its potent somatotropic effects and its high concentration in the fetus supports the hypothesis that oPL may be important in the regulation of fetal growth.</description><subject>Animals</subject><subject>Animals, Newborn - metabolism</subject><subject>Brain - drug effects</subject><subject>Brain - enzymology</subject><subject>Carboxy-Lyases - metabolism</subject><subject>Growth Hormone - pharmacology</subject><subject>Humans</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Ornithine Decarboxylase - metabolism</subject><subject>Placental Lactogen - pharmacology</subject><subject>Prolactin - pharmacology</subject><subject>Rats</subject><subject>Sheep</subject><subject>Stimulation, Chemical</subject><issn>0024-3205</issn><issn>1879-0631</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEFPHCEYhkmjrevWf-CBU1MPozDAwF6aGKNtE5O92DNh4JsWw8IW2I3778u4xmMvQPI97xu-B6FLSq4pocMNIT3vWE_EV6muVoQL0vUf0IIquerIwOgJWrwjZ-i8lGdCiBCSfUIfB9lzLhcorPc-At4GYyFWE3B71PQbIi7Vb3bBVJ8iThNOOfr6Z2YdWJPH9HIIpgBuuN_7esA-4jGbdprocPB7yHMsQopm7s2mls_odDKhwMXbvUS_Hu6f7n50j-vvP-9uHzvLxFA73k-jE44Jznhbww1OOSopSA6KUumUGJUDsuLC9pMjwkygCIwWJmEBjGFL9OXYu83p7w5K1RtfLIRg2nd2RUtO1MCYaiA_gjanUjJMepv9xuSDpkTPjvUsUM8CtVT61bHuW-zyrX83bsC9h45S2_jbcQxtx72HrIv1EC04n8FW7ZL_f_8_YoKNoA</recordid><startdate>19780619</startdate><enddate>19780619</enddate><creator>Butler, S.R.</creator><creator>Hurley, T.W.</creator><creator>Schanberg, S.M.</creator><creator>Handwerger, S.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19780619</creationdate><title>Ovine placental lactogen stimulation of ornithine decarboxylase activity in brain and liver of neonatal rats</title><author>Butler, S.R. ; Hurley, T.W. ; Schanberg, S.M. ; Handwerger, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-42fbd5d35434631d6d8d171e74e8117d85b8de0945c2fd05afe80ebcef5ceeaa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Animals, Newborn - metabolism</topic><topic>Brain - drug effects</topic><topic>Brain - enzymology</topic><topic>Carboxy-Lyases - metabolism</topic><topic>Growth Hormone - pharmacology</topic><topic>Humans</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Ornithine Decarboxylase - metabolism</topic><topic>Placental Lactogen - pharmacology</topic><topic>Prolactin - pharmacology</topic><topic>Rats</topic><topic>Sheep</topic><topic>Stimulation, Chemical</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Butler, S.R.</creatorcontrib><creatorcontrib>Hurley, T.W.</creatorcontrib><creatorcontrib>Schanberg, S.M.</creatorcontrib><creatorcontrib>Handwerger, S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Life sciences (1973)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Butler, S.R.</au><au>Hurley, T.W.</au><au>Schanberg, S.M.</au><au>Handwerger, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Ovine placental lactogen stimulation of ornithine decarboxylase activity in brain and liver of neonatal rats</atitle><jtitle>Life sciences (1973)</jtitle><addtitle>Life Sci</addtitle><date>1978-06-19</date><risdate>1978</risdate><volume>22</volume><issue>23</issue><spage>2073</spage><epage>2078</epage><pages>2073-2078</pages><issn>0024-3205</issn><eissn>1879-0631</eissn><abstract>Ovine placental lactogen (oPL), growth hormone (oGH), prolactin (oPRL) and human placental lactogen (hPL) were administered intracisternally (ic) or intraperitoneally (ip) to 17 day old rats and brain and liver ODC activities determined four hours later. When given ic, oPL, oGH and oPRL caused significant increases in brain ODC activity, while hPL had no significant effect. After ip administration, oPL and oGH also caused a significant increase in brain as well as liver ODC activity but oPRL and hPL were without significant effect. The stimulation of polyamine metabolism by oPL together with earlier reports of its potent somatotropic effects and its high concentration in the fetus supports the hypothesis that oPL may be important in the regulation of fetal growth.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>672447</pmid><doi>10.1016/0024-3205(78)90450-2</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0024-3205 |
| ispartof | Life sciences (1973), 1978-06, Vol.22 (23), p.2073-2078 |
| issn | 0024-3205 1879-0631 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74086338 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Animals, Newborn - metabolism Brain - drug effects Brain - enzymology Carboxy-Lyases - metabolism Growth Hormone - pharmacology Humans Liver - drug effects Liver - enzymology Ornithine Decarboxylase - metabolism Placental Lactogen - pharmacology Prolactin - pharmacology Rats Sheep Stimulation, Chemical |
| title | Ovine placental lactogen stimulation of ornithine decarboxylase activity in brain and liver of neonatal rats |
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