A "carrier effect" observed in assay of antidiarrhoeal drug compounds

A carrier effect has been shown to exist in a stable isotope dilution assay for diphenoxylate. When a tetradeuterated analogue is used as a carrier and internal standard a sevenfold increase in sensitivity is observed for the unlabelled compound. Examination of a related pharmacologically active com...

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Veröffentlicht in:	Biomedical mass spectrometry 1978-06, Vol.5 (6), p.423-424
Hauptverfasser:	Haskins, N J, Ford, G C, Grigson, S J, Waddell, K A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antidiarrheals - analysis Chromatography, Gas - methods Deuterium Diphenoxylate - analysis
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description	A carrier effect has been shown to exist in a stable isotope dilution assay for diphenoxylate. When a tetradeuterated analogue is used as a carrier and internal standard a sevenfold increase in sensitivity is observed for the unlabelled compound. Examination of a related pharmacologically active compound (SC-27166) showed a much smaller effect.
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language	eng
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source	MEDLINE; Alma/SFX Local Collection
subjects	Antidiarrheals - analysis Chromatography, Gas - methods Deuterium Diphenoxylate - analysis
title	A "carrier effect" observed in assay of antidiarrhoeal drug compounds
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