[(3-Aryl-1,2-benzisoxazol-6-yl)oxy]acetic acids. A new diuretic series

A series of [(3-aryl-1,2-benzisoxazol-6-yl)oxy]acetic acids was synthesized and tested for diuretic activity in saline-loaded mice and in conscious, water-loaded dogs. The structural requirements for good diuretic activity in both mice and dogs were found to be very specific. In summary, the compoun...

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Veröffentlicht in:	Journal of medicinal chemistry 1982-01, Vol.25 (1), p.36-44
Hauptverfasser:	Shutske, Gregory M, Setescak, Linda L, Allen, Richard C, Davis, Larry, Effland, Richard C, Ranbom, Karen, Kitzen, Jan M, Wilker, Jeffrey C, Novick, William J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Diuretics - chemical synthesis Diuretics - pharmacology Dogs Isoxazoles - chemical synthesis Isoxazoles - pharmacology Male Mice Oxazoles - chemical synthesis Structure-Activity Relationship Uricosuric Agents - pharmacology
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