Unconjugated steroids in leiomyomas and tumor-bearing myometrium
The concentration of 17β-estradiol, progesterone, and estrone in leiomyomas and tumor-bearing myometrium were determined by specific radioimmunoassays in hysterectomy specimens from 12 women aged between 30 and 47 years. The concentration of 17β-estradiol was significantly higher in leiomyomas than...
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| Veröffentlicht in: | American journal of obstetrics and gynecology 1982-05, Vol.143 (2), p.130-133 |
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| container_end_page | 133 |
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| container_issue | 2 |
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| container_title | American journal of obstetrics and gynecology |
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| creator | Otubu, J.A. Buttram, V.C. Besch, N.F. Besch, P.K. |
| description | The concentration of 17β-estradiol, progesterone, and estrone in leiomyomas and tumor-bearing myometrium were determined by specific radioimmunoassays in hysterectomy specimens from 12 women aged between 30 and 47 years. The concentration of 17β-estradiol was significantly higher in leiomyomas than in myometrium. There was no difference in the concentration of progesterone in leiomyomas and myometrium. The concentration of estrone was higher in the myometrium than in the leiomyomas, although the difference was not statistically significant. The concentrations of progesterone, 17β-estradiol, and to some extent estrone show variation with the phase of the menstrual cycle. The significance of the difference in concentration of 17β-estradiol in leiomyomas and myometrium, the relationship of this difference to the concentrations of estrogen and progesterone receptors, and factors possibly related to the growth of leiomyomas are discussed. |
| doi_str_mv | 10.1016/0002-9378(82)90640-8 |
| format | Article |
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The concentration of 17β-estradiol was significantly higher in leiomyomas than in myometrium. There was no difference in the concentration of progesterone in leiomyomas and myometrium. The concentration of estrone was higher in the myometrium than in the leiomyomas, although the difference was not statistically significant. The concentrations of progesterone, 17β-estradiol, and to some extent estrone show variation with the phase of the menstrual cycle. The significance of the difference in concentration of 17β-estradiol in leiomyomas and myometrium, the relationship of this difference to the concentrations of estrogen and progesterone receptors, and factors possibly related to the growth of leiomyomas are discussed.</description><identifier>ISSN: 0002-9378</identifier><identifier>EISSN: 1097-6868</identifier><identifier>DOI: 10.1016/0002-9378(82)90640-8</identifier><identifier>PMID: 7081322</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Estradiol - analysis ; Estrone - analysis ; Female ; Gonadal Steroid Hormones - analysis ; Humans ; Leiomyoma - analysis ; Menstruation ; Middle Aged ; Myometrium - analysis ; Neoplasms, Hormone-Dependent - analysis ; Progesterone - analysis ; Radioimmunoassay ; Uterine Neoplasms - analysis ; Uterus - analysis</subject><ispartof>American journal of obstetrics and gynecology, 1982-05, Vol.143 (2), p.130-133</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-e82361b4cafd9ee5791d37dd14bfbd5bf1298f4ddb53777f4b4733ad474025d33</citedby><cites>FETCH-LOGICAL-c357t-e82361b4cafd9ee5791d37dd14bfbd5bf1298f4ddb53777f4b4733ad474025d33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9378(82)90640-8$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,777,781,3537,27905,27906,45976</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7081322$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Otubu, J.A.</creatorcontrib><creatorcontrib>Buttram, V.C.</creatorcontrib><creatorcontrib>Besch, N.F.</creatorcontrib><creatorcontrib>Besch, P.K.</creatorcontrib><title>Unconjugated steroids in leiomyomas and tumor-bearing myometrium</title><title>American journal of obstetrics and gynecology</title><addtitle>Am J Obstet Gynecol</addtitle><description>The concentration of 17β-estradiol, progesterone, and estrone in leiomyomas and tumor-bearing myometrium were determined by specific radioimmunoassays in hysterectomy specimens from 12 women aged between 30 and 47 years. The concentration of 17β-estradiol was significantly higher in leiomyomas than in myometrium. There was no difference in the concentration of progesterone in leiomyomas and myometrium. The concentration of estrone was higher in the myometrium than in the leiomyomas, although the difference was not statistically significant. The concentrations of progesterone, 17β-estradiol, and to some extent estrone show variation with the phase of the menstrual cycle. The significance of the difference in concentration of 17β-estradiol in leiomyomas and myometrium, the relationship of this difference to the concentrations of estrogen and progesterone receptors, and factors possibly related to the growth of leiomyomas are discussed.</description><subject>Adult</subject><subject>Estradiol - analysis</subject><subject>Estrone - analysis</subject><subject>Female</subject><subject>Gonadal Steroid Hormones - analysis</subject><subject>Humans</subject><subject>Leiomyoma - analysis</subject><subject>Menstruation</subject><subject>Middle Aged</subject><subject>Myometrium - analysis</subject><subject>Neoplasms, Hormone-Dependent - analysis</subject><subject>Progesterone - analysis</subject><subject>Radioimmunoassay</subject><subject>Uterine Neoplasms - analysis</subject><subject>Uterus - analysis</subject><issn>0002-9378</issn><issn>1097-6868</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLw0AQxxdRaq1-A4WcRA_RfSW7uYhSfEHBiz0v-5iULU227iZCv70JLT16Gob_Y5gfQtcEPxBMykeMMc0rJuSdpPcVLjnO5QmaElyJvJSlPEXTo-UcXaS0Hlda0QmaCCwJo3SKnpetDe26X-kOXJY6iMG7lPk224APzS40OmW6dVnXNyHmBnT07SobBeii75tLdFbrTYKrw5yh5dvr9_wjX3y9f85fFrllhehykJSVxHCra1cBFKIijgnnCDe1cYWpCa1kzZ0zBRNC1NxwwZh2XHBMC8fYDN3ue7cx_PSQOtX4ZGGz0S2EPqnBJzFj5WDke6ONIaUItdpG3-i4UwSrEZwaMaiRipLDHMEpOcRuDv29acAdQwdSg_6012F48tdDVMl6aC04H8F2ygX__4E_NOZ9XQ</recordid><startdate>19820515</startdate><enddate>19820515</enddate><creator>Otubu, J.A.</creator><creator>Buttram, V.C.</creator><creator>Besch, N.F.</creator><creator>Besch, P.K.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19820515</creationdate><title>Unconjugated steroids in leiomyomas and tumor-bearing myometrium</title><author>Otubu, J.A. ; Buttram, V.C. ; Besch, N.F. ; Besch, P.K.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-e82361b4cafd9ee5791d37dd14bfbd5bf1298f4ddb53777f4b4733ad474025d33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Estradiol - analysis</topic><topic>Estrone - analysis</topic><topic>Female</topic><topic>Gonadal Steroid Hormones - analysis</topic><topic>Humans</topic><topic>Leiomyoma - analysis</topic><topic>Menstruation</topic><topic>Middle Aged</topic><topic>Myometrium - analysis</topic><topic>Neoplasms, Hormone-Dependent - analysis</topic><topic>Progesterone - analysis</topic><topic>Radioimmunoassay</topic><topic>Uterine Neoplasms - analysis</topic><topic>Uterus - analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Otubu, J.A.</creatorcontrib><creatorcontrib>Buttram, V.C.</creatorcontrib><creatorcontrib>Besch, N.F.</creatorcontrib><creatorcontrib>Besch, P.K.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of obstetrics and gynecology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Otubu, J.A.</au><au>Buttram, V.C.</au><au>Besch, N.F.</au><au>Besch, P.K.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Unconjugated steroids in leiomyomas and tumor-bearing myometrium</atitle><jtitle>American journal of obstetrics and gynecology</jtitle><addtitle>Am J Obstet Gynecol</addtitle><date>1982-05-15</date><risdate>1982</risdate><volume>143</volume><issue>2</issue><spage>130</spage><epage>133</epage><pages>130-133</pages><issn>0002-9378</issn><eissn>1097-6868</eissn><abstract>The concentration of 17β-estradiol, progesterone, and estrone in leiomyomas and tumor-bearing myometrium were determined by specific radioimmunoassays in hysterectomy specimens from 12 women aged between 30 and 47 years. 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| identifier | ISSN: 0002-9378 |
| ispartof | American journal of obstetrics and gynecology, 1982-05, Vol.143 (2), p.130-133 |
| issn | 0002-9378 1097-6868 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adult Estradiol - analysis Estrone - analysis Female Gonadal Steroid Hormones - analysis Humans Leiomyoma - analysis Menstruation Middle Aged Myometrium - analysis Neoplasms, Hormone-Dependent - analysis Progesterone - analysis Radioimmunoassay Uterine Neoplasms - analysis Uterus - analysis |
| title | Unconjugated steroids in leiomyomas and tumor-bearing myometrium |
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