Highly active position eight analogs of somatostatin and separation of peptide diastereomers by partition chromatography

Six stereochemically pure analogues of somatostatin (SS), D- and L-5F-Trp8-SS, D- and L -6F-Trp8-SS, and D- and L-5Br-Trp8-SS, were synthesized and found to be more potent than somatostatin in suppressing the release of growth hormone from cultured rat pituitary cells. Two of the analogues, D-5F-Trp...

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Veröffentlicht in:	Biochemistry (Easton) 1978-06, Vol.17 (12), p.2326-2331
Hauptverfasser:	Meyers, Chester A, Coy, David H, Huang, W. Y, Schally, Andrew V, Redding, Tommie W
Format:	Artikel
Sprache:	eng
Schlagworte:	Cells, Cultured Chemical Phenomena Chemistry Growth Hormone - metabolism Pituitary Gland - drug effects Pituitary Gland - metabolism Somatostatin - analogs & derivatives Somatostatin - chemical synthesis Somatostatin - pharmacology Stereoisomerism Tryptophan
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