Afterload reduction with nifedipine in aortic insufficiency
The acute hemodynamic effects of nifedipine were assessed In 12 patients with severe isolated aortic Insufficiency during control conditions and 30 minutes after administration of nifedipine (20 mg sublingually). Left ventricular end-diastollc pressure decreased from 19 ± 8 (mean ± standard deviatio...
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| Veröffentlicht in: | The American journal of cardiology 1982-05, Vol.49 (7), p.1728-1732 |
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| container_title | The American journal of cardiology |
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| creator | Fioretti, Paolo Benussi, Bernardo Scardi, Sabino Klugmann, Silvio Brower, Ronald W. Camerini, Fulvio |
| description | The acute hemodynamic effects of nifedipine were assessed In 12 patients with severe isolated aortic Insufficiency during control conditions and 30 minutes after administration of nifedipine (20 mg sublingually). Left ventricular end-diastollc pressure decreased from 19 ± 8 (mean ± standard deviation) to 9 ± 5 mm Hg (probability [p] < 0.0001), mean aortic pressure from 98 ± 12 to 80 ± 9 mm Hg (p < 0.0001), systemic vascular resistance from 1,135 ± 280 to 794 ± 176 dynes·s·cm
−5 (p < 0.0002) and rate-pressure product from 11,732 ± 1,727 to 10,022 ± 1,103 mm Hg
+ beats/min (p < 0.01). Forward cardiac index increased by 24 percent, from 3.8 ± 1.1 to 4.4 ± 0.8 liters/min per m
2 (p < 0.04). Left ventricular end-diastolic volume, ejection fraction and total stroke work index did not change significantly. Regurgitant fraction, measured in five patients, changed parallel with systemic vascular resistance. Left ventricular function was maintained while both preload and afterload were decreased. Regurgitant flow was moderated and myocardial oxygen demand decreased. This hemodynamically favorable condition, due to nifedlpine, is clinically important and suggests the need for further therapeutic trials. |
| doi_str_mv | 10.1016/0002-9149(82)90252-1 |
| format | Article |
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−5 (p < 0.0002) and rate-pressure product from 11,732 ± 1,727 to 10,022 ± 1,103 mm Hg
+ beats/min (p < 0.01). Forward cardiac index increased by 24 percent, from 3.8 ± 1.1 to 4.4 ± 0.8 liters/min per m
2 (p < 0.04). Left ventricular end-diastolic volume, ejection fraction and total stroke work index did not change significantly. Regurgitant fraction, measured in five patients, changed parallel with systemic vascular resistance. Left ventricular function was maintained while both preload and afterload were decreased. Regurgitant flow was moderated and myocardial oxygen demand decreased. This hemodynamically favorable condition, due to nifedlpine, is clinically important and suggests the need for further therapeutic trials.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/0002-9149(82)90252-1</identifier><identifier>PMID: 7081058</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aortic Valve Insufficiency - drug therapy ; Blood Pressure - drug effects ; Cardiac Volume - drug effects ; Female ; Heart Ventricles - drug effects ; Hemodynamics - drug effects ; Humans ; Male ; Middle Aged ; Myocardial Contraction - drug effects ; Nifedipine - therapeutic use ; Pyridines - therapeutic use ; Stroke Volume - drug effects</subject><ispartof>The American journal of cardiology, 1982-05, Vol.49 (7), p.1728-1732</ispartof><rights>1982</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c357t-e9a5f9795a3bdaaa13fd93e848d9d3c2e18caa8050d43f95dbb415ec99936fc63</citedby><cites>FETCH-LOGICAL-c357t-e9a5f9795a3bdaaa13fd93e848d9d3c2e18caa8050d43f95dbb415ec99936fc63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/0002-9149(82)90252-1$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7081058$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fioretti, Paolo</creatorcontrib><creatorcontrib>Benussi, Bernardo</creatorcontrib><creatorcontrib>Scardi, Sabino</creatorcontrib><creatorcontrib>Klugmann, Silvio</creatorcontrib><creatorcontrib>Brower, Ronald W.</creatorcontrib><creatorcontrib>Camerini, Fulvio</creatorcontrib><title>Afterload reduction with nifedipine in aortic insufficiency</title><title>The American journal of cardiology</title><addtitle>Am J Cardiol</addtitle><description>The acute hemodynamic effects of nifedipine were assessed In 12 patients with severe isolated aortic Insufficiency during control conditions and 30 minutes after administration of nifedipine (20 mg sublingually). Left ventricular end-diastollc pressure decreased from 19 ± 8 (mean ± standard deviation) to 9 ± 5 mm Hg (probability [p] < 0.0001), mean aortic pressure from 98 ± 12 to 80 ± 9 mm Hg (p < 0.0001), systemic vascular resistance from 1,135 ± 280 to 794 ± 176 dynes·s·cm
−5 (p < 0.0002) and rate-pressure product from 11,732 ± 1,727 to 10,022 ± 1,103 mm Hg
+ beats/min (p < 0.01). Forward cardiac index increased by 24 percent, from 3.8 ± 1.1 to 4.4 ± 0.8 liters/min per m
2 (p < 0.04). Left ventricular end-diastolic volume, ejection fraction and total stroke work index did not change significantly. Regurgitant fraction, measured in five patients, changed parallel with systemic vascular resistance. Left ventricular function was maintained while both preload and afterload were decreased. Regurgitant flow was moderated and myocardial oxygen demand decreased. This hemodynamically favorable condition, due to nifedlpine, is clinically important and suggests the need for further therapeutic trials.</description><subject>Adult</subject><subject>Aged</subject><subject>Aortic Valve Insufficiency - drug therapy</subject><subject>Blood Pressure - drug effects</subject><subject>Cardiac Volume - drug effects</subject><subject>Female</subject><subject>Heart Ventricles - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardial Contraction - drug effects</subject><subject>Nifedipine - therapeutic use</subject><subject>Pyridines - therapeutic use</subject><subject>Stroke Volume - drug effects</subject><issn>0002-9149</issn><issn>1879-1913</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE9LxDAQxYMo67r6DRR6Ej1Uk6ZpEgRhWfwHC170HNJkgpFuuyatst_e1F326OnNMG_eMD-Ezgm-IZhUtxjjIpeklFeiuJa4YEVODtCUCC5zIgk9RNO95RidxPiZWkJYNUETjgXBTEzR3dz1EJpO2yyAHUzvuzb78f1H1noH1q99C5lvM92F3ptUxcE5bzy0ZnOKjpxuIpztdIbeHx_eFs_58vXpZTFf5oYy3ucgNXOSS6ZpbbXWhDorKYhSWGmpKYAIo7XADNuSOslsXZeEgZFS0sqZis7Q5TZ3HbqvAWKvVj4aaBrdQjdExUvMeVHyZCy3RhO6GAM4tQ5-pcNGEaxGZmoEokYgSiQdmSmS1i52-UO9Artf2kFK8_vtHNKT3x6Cin8AEp4Aple28_8f-AUWznt1</recordid><startdate>198205</startdate><enddate>198205</enddate><creator>Fioretti, Paolo</creator><creator>Benussi, Bernardo</creator><creator>Scardi, Sabino</creator><creator>Klugmann, Silvio</creator><creator>Brower, Ronald W.</creator><creator>Camerini, Fulvio</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198205</creationdate><title>Afterload reduction with nifedipine in aortic insufficiency</title><author>Fioretti, Paolo ; Benussi, Bernardo ; Scardi, Sabino ; Klugmann, Silvio ; Brower, Ronald W. ; Camerini, Fulvio</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c357t-e9a5f9795a3bdaaa13fd93e848d9d3c2e18caa8050d43f95dbb415ec99936fc63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aortic Valve Insufficiency - drug therapy</topic><topic>Blood Pressure - drug effects</topic><topic>Cardiac Volume - drug effects</topic><topic>Female</topic><topic>Heart Ventricles - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardial Contraction - drug effects</topic><topic>Nifedipine - therapeutic use</topic><topic>Pyridines - therapeutic use</topic><topic>Stroke Volume - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fioretti, Paolo</creatorcontrib><creatorcontrib>Benussi, Bernardo</creatorcontrib><creatorcontrib>Scardi, Sabino</creatorcontrib><creatorcontrib>Klugmann, Silvio</creatorcontrib><creatorcontrib>Brower, Ronald W.</creatorcontrib><creatorcontrib>Camerini, Fulvio</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fioretti, Paolo</au><au>Benussi, Bernardo</au><au>Scardi, Sabino</au><au>Klugmann, Silvio</au><au>Brower, Ronald W.</au><au>Camerini, Fulvio</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Afterload reduction with nifedipine in aortic insufficiency</atitle><jtitle>The American journal of cardiology</jtitle><addtitle>Am J Cardiol</addtitle><date>1982-05</date><risdate>1982</risdate><volume>49</volume><issue>7</issue><spage>1728</spage><epage>1732</epage><pages>1728-1732</pages><issn>0002-9149</issn><eissn>1879-1913</eissn><abstract>The acute hemodynamic effects of nifedipine were assessed In 12 patients with severe isolated aortic Insufficiency during control conditions and 30 minutes after administration of nifedipine (20 mg sublingually). Left ventricular end-diastollc pressure decreased from 19 ± 8 (mean ± standard deviation) to 9 ± 5 mm Hg (probability [p] < 0.0001), mean aortic pressure from 98 ± 12 to 80 ± 9 mm Hg (p < 0.0001), systemic vascular resistance from 1,135 ± 280 to 794 ± 176 dynes·s·cm
−5 (p < 0.0002) and rate-pressure product from 11,732 ± 1,727 to 10,022 ± 1,103 mm Hg
+ beats/min (p < 0.01). Forward cardiac index increased by 24 percent, from 3.8 ± 1.1 to 4.4 ± 0.8 liters/min per m
2 (p < 0.04). Left ventricular end-diastolic volume, ejection fraction and total stroke work index did not change significantly. Regurgitant fraction, measured in five patients, changed parallel with systemic vascular resistance. Left ventricular function was maintained while both preload and afterload were decreased. Regurgitant flow was moderated and myocardial oxygen demand decreased. This hemodynamically favorable condition, due to nifedlpine, is clinically important and suggests the need for further therapeutic trials.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>7081058</pmid><doi>10.1016/0002-9149(82)90252-1</doi><tpages>5</tpages></addata></record> |
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| identifier | ISSN: 0002-9149 |
| ispartof | The American journal of cardiology, 1982-05, Vol.49 (7), p.1728-1732 |
| issn | 0002-9149 1879-1913 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Aged Aortic Valve Insufficiency - drug therapy Blood Pressure - drug effects Cardiac Volume - drug effects Female Heart Ventricles - drug effects Hemodynamics - drug effects Humans Male Middle Aged Myocardial Contraction - drug effects Nifedipine - therapeutic use Pyridines - therapeutic use Stroke Volume - drug effects |
| title | Afterload reduction with nifedipine in aortic insufficiency |
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