Effect of asphyxia on theophylline clearance in newborns

The effect of asphyxia on theophylline clearance was studied in 30 newborns who were matched for gestational age, postnatal age, and the presence or absence of asphyxia. Asphyxiated newborns cleared theophylline at approximately half the rate of nonasphyxiated newborns. We found that, in order to ac...

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Veröffentlicht in:	Southern medical journal (Birmingham, Ala.) Ala.), 1982-07, Vol.75 (7), p.836-838
Hauptverfasser:	Gal, P, Boer, H R, Toback, J, Wells, T J, Erkan, N V
Format:	Artikel
Sprache:	eng
Schlagworte:	Asphyxia Neonatorum - blood Asphyxia Neonatorum - drug therapy Humans Infant, Newborn Theophylline - administration & dosage Theophylline - blood Theophylline - pharmacology
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creator	Gal, P Boer, H R Toback, J Wells, T J Erkan, N V
description	The effect of asphyxia on theophylline clearance was studied in 30 newborns who were matched for gestational age, postnatal age, and the presence or absence of asphyxia. Asphyxiated newborns cleared theophylline at approximately half the rate of nonasphyxiated newborns. We found that, in order to achieve a steady-state plasma concentration of 8 mg/L of theophylline, asphyxiated neonates should receive 2.1 mg/kg/day, while nonasphyxiated neonates should receive 3.9 mg/kg/day.
doi_str_mv	10.1097/00007611-198207000-00017
format	Article
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We found that, in order to achieve a steady-state plasma concentration of 8 mg/L of theophylline, asphyxiated neonates should receive 2.1 mg/kg/day, while nonasphyxiated neonates should receive 3.9 mg/kg/day.</description><identifier>ISSN: 0038-4348</identifier><identifier>DOI: 10.1097/00007611-198207000-00017</identifier><identifier>PMID: 7089654</identifier><language>eng</language><publisher>United States</publisher><subject>Asphyxia Neonatorum - blood ; Asphyxia Neonatorum - drug therapy ; Humans ; Infant, Newborn ; Theophylline - administration & dosage ; Theophylline - blood ; Theophylline - pharmacology</subject><ispartof>Southern medical journal (Birmingham, Ala.), 1982-07, Vol.75 (7), p.836-838</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c310t-2340e12970c49047b776acb152463ee9bec9f49c90f87c1f051f5e73dcbf6033</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7089654$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gal, P</creatorcontrib><creatorcontrib>Boer, H R</creatorcontrib><creatorcontrib>Toback, J</creatorcontrib><creatorcontrib>Wells, T J</creatorcontrib><creatorcontrib>Erkan, N V</creatorcontrib><title>Effect of asphyxia on theophylline clearance in newborns</title><title>Southern medical journal (Birmingham, Ala.)</title><addtitle>South Med J</addtitle><description>The effect of asphyxia on theophylline clearance was studied in 30 newborns who were matched for gestational age, postnatal age, and the presence or absence of asphyxia. Asphyxiated newborns cleared theophylline at approximately half the rate of nonasphyxiated newborns. We found that, in order to achieve a steady-state plasma concentration of 8 mg/L of theophylline, asphyxiated neonates should receive 2.1 mg/kg/day, while nonasphyxiated neonates should receive 3.9 mg/kg/day.</description><subject>Asphyxia Neonatorum - blood</subject><subject>Asphyxia Neonatorum - drug therapy</subject><subject>Humans</subject><subject>Infant, Newborn</subject><subject>Theophylline - administration & dosage</subject><subject>Theophylline - blood</subject><subject>Theophylline - pharmacology</subject><issn>0038-4348</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1LAzEQxXNQaq3-CUJO3lYnm2w-jlLqBxS89B6y6YSubJOabNH-925tdWAYHrw3D36EUAYPDIx6hHGUZKxiRtegRlWNy9QFmQJwXQku9BW5LuXjaGy0nJCJAm1kI6ZEL0JAP9AUqCu7zeG7czRFOmwwjarvu4jU9-iyix5pF2nErzblWG7IZXB9wdvznZHV82I1f62W7y9v86dl5TmDoaq5AGS1UeCFAaFapaTzLWtqITmiadGbIIw3ELTyLEDDQoOKr30bJHA-I_ent7ucPvdYBrvtise-dxHTvlglQHHG5WjUJ6PPqZSMwe5yt3X5YBnYIyf7x8n-c7K_nMbo3blj325x_R88Q-I_BjxkTA</recordid><startdate>198207</startdate><enddate>198207</enddate><creator>Gal, P</creator><creator>Boer, H R</creator><creator>Toback, J</creator><creator>Wells, T J</creator><creator>Erkan, N V</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198207</creationdate><title>Effect of asphyxia on theophylline clearance in newborns</title><author>Gal, P ; Boer, H R ; Toback, J ; Wells, T J ; Erkan, N V</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c310t-2340e12970c49047b776acb152463ee9bec9f49c90f87c1f051f5e73dcbf6033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Asphyxia Neonatorum - blood</topic><topic>Asphyxia Neonatorum - drug therapy</topic><topic>Humans</topic><topic>Infant, Newborn</topic><topic>Theophylline - administration & dosage</topic><topic>Theophylline - blood</topic><topic>Theophylline - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gal, P</creatorcontrib><creatorcontrib>Boer, H R</creatorcontrib><creatorcontrib>Toback, J</creatorcontrib><creatorcontrib>Wells, T J</creatorcontrib><creatorcontrib>Erkan, N V</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Southern medical journal (Birmingham, Ala.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gal, P</au><au>Boer, H R</au><au>Toback, J</au><au>Wells, T J</au><au>Erkan, N V</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of asphyxia on theophylline clearance in newborns</atitle><jtitle>Southern medical journal (Birmingham, Ala.)</jtitle><addtitle>South Med J</addtitle><date>1982-07</date><risdate>1982</risdate><volume>75</volume><issue>7</issue><spage>836</spage><epage>838</epage><pages>836-838</pages><issn>0038-4348</issn><abstract>The effect of asphyxia on theophylline clearance was studied in 30 newborns who were matched for gestational age, postnatal age, and the presence or absence of asphyxia. 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source	MEDLINE; Journals@Ovid Complete
subjects	Asphyxia Neonatorum - blood Asphyxia Neonatorum - drug therapy Humans Infant, Newborn Theophylline - administration & dosage Theophylline - blood Theophylline - pharmacology
title	Effect of asphyxia on theophylline clearance in newborns
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