The Effects of Prostaglandins on Extrarenal Erythropoietin Production
Abstract The E and A series prostaglandins have been reported to stimulate erythropoiesis and renal erythropoietin (Ep) production. In the present study, these prostaglandins also stimulated the elaboration of extrarenal Ep in renoprival animals after hypoxia. This extrarenal response was primarily...
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| Veröffentlicht in: | Experimental biology and medicine (Maywood, N.J.) N.J.), 1982-06, Vol.170 (2), p.231-236 |
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| container_title | Experimental biology and medicine (Maywood, N.J.) |
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| creator | Naughton, Brian A. Naughton, Gail K. Liu, Philip Arce, Janet M. Piliero, Sam J. Gordon, Albert S. |
| description | Abstract
The E and A series prostaglandins have been reported to stimulate erythropoiesis and renal erythropoietin (Ep) production. In the present study, these prostaglandins also stimulated the elaboration of extrarenal Ep in renoprival animals after hypoxia. This extrarenal response was primarily due to hepatic Ep synthesis; when subtotal hepatectomy (hepx) was followed by nephrectomy, the Ep response to hypoxia was almost completely abolished. The synthetic methylated prostaglandins (16, 16-dimethyl E2 and (15s)-15 methyl E2) exerted the most potent effects on both the hepatic and renal Ep response. It is believed that this is attributable, at least in part, to the greater stability of these compounds in vivo. Prostaglandins do not appear to be capable of substantially elevating Ep production by the regenerating liver. When compared to vehicle- or saline-injected rats, a greater stimulation of hepatic Ep elaboration after prostaglandin treatment was observed in animals with normal livers than in rats with liver regenerating 72 hr after hepx. |
| doi_str_mv | 10.3181/00379727-170-41424 |
| format | Article |
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The E and A series prostaglandins have been reported to stimulate erythropoiesis and renal erythropoietin (Ep) production. In the present study, these prostaglandins also stimulated the elaboration of extrarenal Ep in renoprival animals after hypoxia. This extrarenal response was primarily due to hepatic Ep synthesis; when subtotal hepatectomy (hepx) was followed by nephrectomy, the Ep response to hypoxia was almost completely abolished. The synthetic methylated prostaglandins (16, 16-dimethyl E2 and (15s)-15 methyl E2) exerted the most potent effects on both the hepatic and renal Ep response. It is believed that this is attributable, at least in part, to the greater stability of these compounds in vivo. Prostaglandins do not appear to be capable of substantially elevating Ep production by the regenerating liver. When compared to vehicle- or saline-injected rats, a greater stimulation of hepatic Ep elaboration after prostaglandin treatment was observed in animals with normal livers than in rats with liver regenerating 72 hr after hepx.</description><identifier>ISSN: 0037-9727</identifier><identifier>ISSN: 1535-3702</identifier><identifier>EISSN: 1535-3699</identifier><identifier>DOI: 10.3181/00379727-170-41424</identifier><identifier>PMID: 6953451</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>16,16-Dimethylprostaglandin E2 - pharmacology ; Alprostadil ; Animals ; Arbaprostil - pharmacology ; Dinoprost ; Dinoprostone ; Erythropoietin - biosynthesis ; Half-Life ; Liver - metabolism ; Liver Regeneration ; Male ; Prostaglandins A - pharmacology ; Prostaglandins E - pharmacology ; Prostaglandins F - pharmacology ; Rats</subject><ispartof>Experimental biology and medicine (Maywood, N.J.), 1982-06, Vol.170 (2), p.231-236</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c253t-c2c162ce97ba8e1fdeebd9c6da62b4a65071ffb386462ef5bd55d9d107c74fe43</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6953451$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Naughton, Brian A.</creatorcontrib><creatorcontrib>Naughton, Gail K.</creatorcontrib><creatorcontrib>Liu, Philip</creatorcontrib><creatorcontrib>Arce, Janet M.</creatorcontrib><creatorcontrib>Piliero, Sam J.</creatorcontrib><creatorcontrib>Gordon, Albert S.</creatorcontrib><title>The Effects of Prostaglandins on Extrarenal Erythropoietin Production</title><title>Experimental biology and medicine (Maywood, N.J.)</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Abstract
The E and A series prostaglandins have been reported to stimulate erythropoiesis and renal erythropoietin (Ep) production. In the present study, these prostaglandins also stimulated the elaboration of extrarenal Ep in renoprival animals after hypoxia. This extrarenal response was primarily due to hepatic Ep synthesis; when subtotal hepatectomy (hepx) was followed by nephrectomy, the Ep response to hypoxia was almost completely abolished. The synthetic methylated prostaglandins (16, 16-dimethyl E2 and (15s)-15 methyl E2) exerted the most potent effects on both the hepatic and renal Ep response. It is believed that this is attributable, at least in part, to the greater stability of these compounds in vivo. Prostaglandins do not appear to be capable of substantially elevating Ep production by the regenerating liver. When compared to vehicle- or saline-injected rats, a greater stimulation of hepatic Ep elaboration after prostaglandin treatment was observed in animals with normal livers than in rats with liver regenerating 72 hr after hepx.</description><subject>16,16-Dimethylprostaglandin E2 - pharmacology</subject><subject>Alprostadil</subject><subject>Animals</subject><subject>Arbaprostil - pharmacology</subject><subject>Dinoprost</subject><subject>Dinoprostone</subject><subject>Erythropoietin - biosynthesis</subject><subject>Half-Life</subject><subject>Liver - metabolism</subject><subject>Liver Regeneration</subject><subject>Male</subject><subject>Prostaglandins A - pharmacology</subject><subject>Prostaglandins E - pharmacology</subject><subject>Prostaglandins F - pharmacology</subject><subject>Rats</subject><issn>0037-9727</issn><issn>1535-3702</issn><issn>1535-3699</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EKqXwA0hIWbELtR0_kiWqwkOqBIuythx73KZKk2InEv17HFpYsvFInjNXMwehW4IfMpKTOcaZLCSVKZE4ZYRRdoamhGc8zURRnKPpCKQjcYmuQthiTLikYoImouAZ42SKytUGktI5MH1IOpe8-y70et3o1tZt_GmT8qv32kOrm6T0h37ju31XQ1-3I2sH09dde40unG4C3JzqDH08lavFS7p8e35dPC5TQ3nWx9cQQQ0UstI5EGcBKlsYYbWgFdOCY0mcq7JcMEHB8cpybgtLsDSSOWDZDN0fc_e--xwg9GpXBwNNXBe6ISjJsMSU5RGkR9DEe4IHp_a-3ml_UASr0Z36daeiO_XjLg7dndKHagf2b-QkK_bnx37Qa1DbbvBRSvgv8RsVunh7</recordid><startdate>198206</startdate><enddate>198206</enddate><creator>Naughton, Brian A.</creator><creator>Naughton, Gail K.</creator><creator>Liu, Philip</creator><creator>Arce, Janet M.</creator><creator>Piliero, Sam J.</creator><creator>Gordon, Albert S.</creator><general>SAGE Publications</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>198206</creationdate><title>The Effects of Prostaglandins on Extrarenal Erythropoietin Production</title><author>Naughton, Brian A. ; Naughton, Gail K. ; Liu, Philip ; Arce, Janet M. ; Piliero, Sam J. ; Gordon, Albert S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c253t-c2c162ce97ba8e1fdeebd9c6da62b4a65071ffb386462ef5bd55d9d107c74fe43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>16,16-Dimethylprostaglandin E2 - pharmacology</topic><topic>Alprostadil</topic><topic>Animals</topic><topic>Arbaprostil - pharmacology</topic><topic>Dinoprost</topic><topic>Dinoprostone</topic><topic>Erythropoietin - biosynthesis</topic><topic>Half-Life</topic><topic>Liver - metabolism</topic><topic>Liver Regeneration</topic><topic>Male</topic><topic>Prostaglandins A - pharmacology</topic><topic>Prostaglandins E - pharmacology</topic><topic>Prostaglandins F - pharmacology</topic><topic>Rats</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Naughton, Brian A.</creatorcontrib><creatorcontrib>Naughton, Gail K.</creatorcontrib><creatorcontrib>Liu, Philip</creatorcontrib><creatorcontrib>Arce, Janet M.</creatorcontrib><creatorcontrib>Piliero, Sam J.</creatorcontrib><creatorcontrib>Gordon, Albert S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Naughton, Brian A.</au><au>Naughton, Gail K.</au><au>Liu, Philip</au><au>Arce, Janet M.</au><au>Piliero, Sam J.</au><au>Gordon, Albert S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effects of Prostaglandins on Extrarenal Erythropoietin Production</atitle><jtitle>Experimental biology and medicine (Maywood, N.J.)</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1982-06</date><risdate>1982</risdate><volume>170</volume><issue>2</issue><spage>231</spage><epage>236</epage><pages>231-236</pages><issn>0037-9727</issn><issn>1535-3702</issn><eissn>1535-3699</eissn><abstract>Abstract
The E and A series prostaglandins have been reported to stimulate erythropoiesis and renal erythropoietin (Ep) production. In the present study, these prostaglandins also stimulated the elaboration of extrarenal Ep in renoprival animals after hypoxia. This extrarenal response was primarily due to hepatic Ep synthesis; when subtotal hepatectomy (hepx) was followed by nephrectomy, the Ep response to hypoxia was almost completely abolished. The synthetic methylated prostaglandins (16, 16-dimethyl E2 and (15s)-15 methyl E2) exerted the most potent effects on both the hepatic and renal Ep response. It is believed that this is attributable, at least in part, to the greater stability of these compounds in vivo. Prostaglandins do not appear to be capable of substantially elevating Ep production by the regenerating liver. When compared to vehicle- or saline-injected rats, a greater stimulation of hepatic Ep elaboration after prostaglandin treatment was observed in animals with normal livers than in rats with liver regenerating 72 hr after hepx.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>6953451</pmid><doi>10.3181/00379727-170-41424</doi><tpages>6</tpages></addata></record> |
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| ispartof | Experimental biology and medicine (Maywood, N.J.), 1982-06, Vol.170 (2), p.231-236 |
| issn | 0037-9727 1535-3702 1535-3699 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | 16,16-Dimethylprostaglandin E2 - pharmacology Alprostadil Animals Arbaprostil - pharmacology Dinoprost Dinoprostone Erythropoietin - biosynthesis Half-Life Liver - metabolism Liver Regeneration Male Prostaglandins A - pharmacology Prostaglandins E - pharmacology Prostaglandins F - pharmacology Rats |
| title | The Effects of Prostaglandins on Extrarenal Erythropoietin Production |
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