COMPARISON OF BL-S786 WITH CEPHALOTHIN, CEFAMANDOLE AND CEFOXITIN IN VITRO AND IN TREATMENT OF EXPERIMENTAL INFECTIONS IN MICE
The activity of BL-S786 was compared to that of cephalothin, cefamandole and cefoxitin in vitro and in treatment of experimental infections in mice. In broth dilution tests, the activity of BL-S786 was less than cephalothin or cefamandole against Staphylococcus aureus and less than cefamandole or ce...
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| Veröffentlicht in: | Journal of antibiotics 1978, Vol.31(4), pp.363-372 |
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| container_end_page | 372 |
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| container_issue | 4 |
| container_start_page | 363 |
| container_title | Journal of antibiotics |
| container_volume | 31 |
| creator | GOERING, RICHARD V. SANDERS, CHRISTINE C. SANDERS, W. EUGENE, Jr |
| description | The activity of BL-S786 was compared to that of cephalothin, cefamandole and cefoxitin in vitro and in treatment of experimental infections in mice. In broth dilution tests, the activity of BL-S786 was less than cephalothin or cefamandole against Staphylococcus aureus and less than cefamandole or cefoxitin against Haemophilus influenzae. BL-S786 and cefamandole were the two most active drugs against cephalothin-sensitive Enterobacteriaceae. In tests with cephalothin-resistant Enterobacteriaceae, BL-S786 was generally less active than cefamandole but more active than cefoxitin against all strains except Proteus and Providencia. Regardless of the comparative in vitro activity of the four drugs, BL-S786 was the most effective drug in treatment of mice lethally infected with Enterobacteriaceae. Protection from lethality was associated with clearance of bacteremia by each of the four drugs. In several tests where in vitro activity was not predictive of in vivo efficacy, selection of resistance in vivo was found to have occurred. |
| doi_str_mv | 10.7164/antibiotics.31.363 |
| format | Article |
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EUGENE, Jr</creator><creatorcontrib>GOERING, RICHARD V. ; SANDERS, CHRISTINE C. ; SANDERS, W. EUGENE, Jr</creatorcontrib><description>The activity of BL-S786 was compared to that of cephalothin, cefamandole and cefoxitin in vitro and in treatment of experimental infections in mice. In broth dilution tests, the activity of BL-S786 was less than cephalothin or cefamandole against Staphylococcus aureus and less than cefamandole or cefoxitin against Haemophilus influenzae. BL-S786 and cefamandole were the two most active drugs against cephalothin-sensitive Enterobacteriaceae. In tests with cephalothin-resistant Enterobacteriaceae, BL-S786 was generally less active than cefamandole but more active than cefoxitin against all strains except Proteus and Providencia. Regardless of the comparative in vitro activity of the four drugs, BL-S786 was the most effective drug in treatment of mice lethally infected with Enterobacteriaceae. Protection from lethality was associated with clearance of bacteremia by each of the four drugs. In several tests where in vitro activity was not predictive of in vivo efficacy, selection of resistance in vivo was found to have occurred.</description><identifier>ISSN: 0021-8820</identifier><identifier>EISSN: 1881-1469</identifier><identifier>DOI: 10.7164/antibiotics.31.363</identifier><identifier>PMID: 306989</identifier><language>eng</language><publisher>Japan: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</publisher><subject>Animals ; Cefamandole - pharmacology ; Cefamandole - therapeutic use ; Cefoxitin - pharmacology ; Cefoxitin - therapeutic use ; Cephalosporins - pharmacology ; Cephalosporins - therapeutic use ; Cephalothin - pharmacology ; Cephalothin - therapeutic use ; Drug Resistance, Microbial ; Enterobacteriaceae - drug effects ; Enterobacteriaceae Infections - drug therapy ; Haemophilus influenzae - drug effects ; Mice ; Mice, Inbred ICR ; Microbial Sensitivity Tests ; Staphylococcus aureus - drug effects</subject><ispartof>The Journal of Antibiotics, 1978, Vol.31(4), pp.363-372</ispartof><rights>Japan Antibiotics Research Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3903-455897b35bcc9feb129dd939a01bc0b222d3bc2fa677d6d379687bc59dcb68b23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,1883,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/306989$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GOERING, RICHARD V.</creatorcontrib><creatorcontrib>SANDERS, CHRISTINE C.</creatorcontrib><creatorcontrib>SANDERS, W. EUGENE, Jr</creatorcontrib><title>COMPARISON OF BL-S786 WITH CEPHALOTHIN, CEFAMANDOLE AND CEFOXITIN IN VITRO AND IN TREATMENT OF EXPERIMENTAL INFECTIONS IN MICE</title><title>Journal of antibiotics</title><addtitle>J. Antibiot.</addtitle><description>The activity of BL-S786 was compared to that of cephalothin, cefamandole and cefoxitin in vitro and in treatment of experimental infections in mice. In broth dilution tests, the activity of BL-S786 was less than cephalothin or cefamandole against Staphylococcus aureus and less than cefamandole or cefoxitin against Haemophilus influenzae. BL-S786 and cefamandole were the two most active drugs against cephalothin-sensitive Enterobacteriaceae. In tests with cephalothin-resistant Enterobacteriaceae, BL-S786 was generally less active than cefamandole but more active than cefoxitin against all strains except Proteus and Providencia. Regardless of the comparative in vitro activity of the four drugs, BL-S786 was the most effective drug in treatment of mice lethally infected with Enterobacteriaceae. Protection from lethality was associated with clearance of bacteremia by each of the four drugs. In several tests where in vitro activity was not predictive of in vivo efficacy, selection of resistance in vivo was found to have occurred.</description><subject>Animals</subject><subject>Cefamandole - pharmacology</subject><subject>Cefamandole - therapeutic use</subject><subject>Cefoxitin - pharmacology</subject><subject>Cefoxitin - therapeutic use</subject><subject>Cephalosporins - pharmacology</subject><subject>Cephalosporins - therapeutic use</subject><subject>Cephalothin - pharmacology</subject><subject>Cephalothin - therapeutic use</subject><subject>Drug Resistance, Microbial</subject><subject>Enterobacteriaceae - drug effects</subject><subject>Enterobacteriaceae Infections - drug therapy</subject><subject>Haemophilus influenzae - drug effects</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Microbial Sensitivity Tests</subject><subject>Staphylococcus aureus - drug effects</subject><issn>0021-8820</issn><issn>1881-1469</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMlu2zAYhImgm5v2BYoedOopcrnIXI6qStdEZcmwlTY3gqToVoGXVLQPufTZQ8WGEYAgMZz5PxIDwCcExwzR7KvZHTrb7Q-dC2OCxoSSKzBCnKMUZVS8AiMIMUo5x_AdeB_CPYSEEcbfgjcEUsHFCPwv6vkiX6pVXSX1NPlWpivGafJbNbOkkItZXtbNTFU3UUzzeV59r0uZxGPQ9Z1qVJXE9Us1y_r5OopmKfNmLqtmAMq7hVyqQeVlNKeyaFRdrYbcXBXyA3i9NpvgP57Pa3A7lU0xS8v6hyryMnVEQJJmkwkXzJKJdU6svUVYtK0gwkBkHbQY45ZYh9eGMtbSljBBObNuIlpnKbeYXIMvJ-5Dv_939OGgt11wfrMxO78_Bs0ySGF8IgbxKej6fQi9X-uHvtua_lEjqIfO9YvONUE6dh6HPp_pR7v17WXkVHK0f57s-3Awf_zFNn2EbPxLIoofH6jZeaPkknJ_Ta_9jjwBNueQ2A</recordid><startdate>1978</startdate><enddate>1978</enddate><creator>GOERING, RICHARD V.</creator><creator>SANDERS, CHRISTINE C.</creator><creator>SANDERS, W. EUGENE, Jr</creator><general>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>1978</creationdate><title>COMPARISON OF BL-S786 WITH CEPHALOTHIN, CEFAMANDOLE AND CEFOXITIN IN VITRO AND IN TREATMENT OF EXPERIMENTAL INFECTIONS IN MICE</title><author>GOERING, RICHARD V. ; SANDERS, CHRISTINE C. ; SANDERS, W. EUGENE, Jr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3903-455897b35bcc9feb129dd939a01bc0b222d3bc2fa677d6d379687bc59dcb68b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Cefamandole - pharmacology</topic><topic>Cefamandole - therapeutic use</topic><topic>Cefoxitin - pharmacology</topic><topic>Cefoxitin - therapeutic use</topic><topic>Cephalosporins - pharmacology</topic><topic>Cephalosporins - therapeutic use</topic><topic>Cephalothin - pharmacology</topic><topic>Cephalothin - therapeutic use</topic><topic>Drug Resistance, Microbial</topic><topic>Enterobacteriaceae - drug effects</topic><topic>Enterobacteriaceae Infections - drug therapy</topic><topic>Haemophilus influenzae - drug effects</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Microbial Sensitivity Tests</topic><topic>Staphylococcus aureus - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GOERING, RICHARD V.</creatorcontrib><creatorcontrib>SANDERS, CHRISTINE C.</creatorcontrib><creatorcontrib>SANDERS, W. EUGENE, Jr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of antibiotics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GOERING, RICHARD V.</au><au>SANDERS, CHRISTINE C.</au><au>SANDERS, W. EUGENE, Jr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>COMPARISON OF BL-S786 WITH CEPHALOTHIN, CEFAMANDOLE AND CEFOXITIN IN VITRO AND IN TREATMENT OF EXPERIMENTAL INFECTIONS IN MICE</atitle><jtitle>Journal of antibiotics</jtitle><addtitle>J. Antibiot.</addtitle><date>1978</date><risdate>1978</risdate><volume>31</volume><issue>4</issue><spage>363</spage><epage>372</epage><pages>363-372</pages><issn>0021-8820</issn><eissn>1881-1469</eissn><abstract>The activity of BL-S786 was compared to that of cephalothin, cefamandole and cefoxitin in vitro and in treatment of experimental infections in mice. In broth dilution tests, the activity of BL-S786 was less than cephalothin or cefamandole against Staphylococcus aureus and less than cefamandole or cefoxitin against Haemophilus influenzae. BL-S786 and cefamandole were the two most active drugs against cephalothin-sensitive Enterobacteriaceae. In tests with cephalothin-resistant Enterobacteriaceae, BL-S786 was generally less active than cefamandole but more active than cefoxitin against all strains except Proteus and Providencia. Regardless of the comparative in vitro activity of the four drugs, BL-S786 was the most effective drug in treatment of mice lethally infected with Enterobacteriaceae. Protection from lethality was associated with clearance of bacteremia by each of the four drugs. In several tests where in vitro activity was not predictive of in vivo efficacy, selection of resistance in vivo was found to have occurred.</abstract><cop>Japan</cop><pub>JAPAN ANTIBIOTICS RESEARCH ASSOCIATION</pub><pmid>306989</pmid><doi>10.7164/antibiotics.31.363</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0021-8820 |
| ispartof | The Journal of Antibiotics, 1978, Vol.31(4), pp.363-372 |
| issn | 0021-8820 1881-1469 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_74060897 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese |
| subjects | Animals Cefamandole - pharmacology Cefamandole - therapeutic use Cefoxitin - pharmacology Cefoxitin - therapeutic use Cephalosporins - pharmacology Cephalosporins - therapeutic use Cephalothin - pharmacology Cephalothin - therapeutic use Drug Resistance, Microbial Enterobacteriaceae - drug effects Enterobacteriaceae Infections - drug therapy Haemophilus influenzae - drug effects Mice Mice, Inbred ICR Microbial Sensitivity Tests Staphylococcus aureus - drug effects |
| title | COMPARISON OF BL-S786 WITH CEPHALOTHIN, CEFAMANDOLE AND CEFOXITIN IN VITRO AND IN TREATMENT OF EXPERIMENTAL INFECTIONS IN MICE |
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