Biological Effects of Nonalkaloid-Containing Fractions of Erythroxylon coca
Water soluble nonalkaloid fractions of Erythroxylon coca were screened in mice for their effects on oxygen utilization and central nervous system (CNS) activity. The fractions were screened in dogs for cardiovascular, blood glucose, and respiratory changes. No CNS effects were demonstrated in mice;...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 1982-06, Vol.71 (6), p.677-679 |
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| container_end_page | 679 |
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| container_issue | 6 |
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| container_title | Journal of pharmaceutical sciences |
| container_volume | 71 |
| creator | Harland, Ernest C. Murphy, James C. Elsohly, Hala Greubel, Deborah Turner, Carlton E. Watson, E.S. |
| description | Water soluble nonalkaloid fractions of Erythroxylon coca were screened in mice for their effects on oxygen utilization and central nervous system (CNS) activity. The fractions were screened in dogs for cardiovascular, blood glucose, and respiratory changes. No CNS effects were demonstrated in mice; however, there was a reduction in the oxygen utilization rate. Intravenous administration of the extract to dogs produced hyperglycemia, a reduction in heart rate, and a decrease in blood pressure. No substantial change in the respiratory rate and tidal or minute volumes were observed. |
| doi_str_mv | 10.1002/jps.2600710618 |
| format | Article |
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The fractions were screened in dogs for cardiovascular, blood glucose, and respiratory changes. No CNS effects were demonstrated in mice; however, there was a reduction in the oxygen utilization rate. Intravenous administration of the extract to dogs produced hyperglycemia, a reduction in heart rate, and a decrease in blood pressure. No substantial change in the respiratory rate and tidal or minute volumes were observed.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1002/jps.2600710618</identifier><identifier>PMID: 7097533</identifier><language>eng</language><publisher>Washington: Elsevier Inc</publisher><subject>Animals ; Blood Glucose - metabolism ; Blood Pressure - drug effects ; CNS activity-effect of nonalkaloid-containing fractions of Erythroxylon coca ; Coca ; Dogs ; effects ; Erythroxylon coca-biological effects of nonalkaloid-containing fractions ; Heart Rate - drug effects ; Hemodynamics - drug effects ; Male ; Mice ; Mice, Inbred ICR ; Motor Activity - drug effects ; Nonalkaloids-fractions in Erythroxylon coca ; Nonalkaloids—fractions in Erythroxylon coca, effects ; Oxygen Consumption - drug effects ; Oxygen utilization rate-effects of Erythroxylon coca on oxygen utilization rate ; Oxygen utilization rate—effects of Erythroxylon coca on oxygen utilization rate, mice, dogs ; Plant Extracts - pharmacology ; Plants, Medicinal ; Respiration - drug effects</subject><ispartof>Journal of pharmaceutical sciences, 1982-06, Vol.71 (6), p.677-679</ispartof><rights>1982 Wiley-Liss, Inc., A Wiley Company</rights><rights>Copyright © 1982 Wiley‐Liss, Inc., A Wiley Company</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4588-eeb85f83173489b81acb6c83a43d8a7fef63b01b3a2cd87dacdde1ffbd34c16e3</citedby><cites>FETCH-LOGICAL-c4588-eeb85f83173489b81acb6c83a43d8a7fef63b01b3a2cd87dacdde1ffbd34c16e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjps.2600710618$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjps.2600710618$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7097533$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Harland, Ernest C.</creatorcontrib><creatorcontrib>Murphy, James C.</creatorcontrib><creatorcontrib>Elsohly, Hala</creatorcontrib><creatorcontrib>Greubel, Deborah</creatorcontrib><creatorcontrib>Turner, Carlton E.</creatorcontrib><creatorcontrib>Watson, E.S.</creatorcontrib><title>Biological Effects of Nonalkaloid-Containing Fractions of Erythroxylon coca</title><title>Journal of pharmaceutical sciences</title><addtitle>J. Pharm. Sci</addtitle><description>Water soluble nonalkaloid fractions of Erythroxylon coca were screened in mice for their effects on oxygen utilization and central nervous system (CNS) activity. The fractions were screened in dogs for cardiovascular, blood glucose, and respiratory changes. No CNS effects were demonstrated in mice; however, there was a reduction in the oxygen utilization rate. Intravenous administration of the extract to dogs produced hyperglycemia, a reduction in heart rate, and a decrease in blood pressure. No substantial change in the respiratory rate and tidal or minute volumes were observed.</description><subject>Animals</subject><subject>Blood Glucose - metabolism</subject><subject>Blood Pressure - drug effects</subject><subject>CNS activity-effect of nonalkaloid-containing fractions of Erythroxylon coca</subject><subject>Coca</subject><subject>Dogs</subject><subject>effects</subject><subject>Erythroxylon coca-biological effects of nonalkaloid-containing fractions</subject><subject>Heart Rate - drug effects</subject><subject>Hemodynamics - drug effects</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred ICR</subject><subject>Motor Activity - drug effects</subject><subject>Nonalkaloids-fractions in Erythroxylon coca</subject><subject>Nonalkaloids—fractions in Erythroxylon coca, effects</subject><subject>Oxygen Consumption - drug effects</subject><subject>Oxygen utilization rate-effects of Erythroxylon coca on oxygen utilization rate</subject><subject>Oxygen utilization rate—effects of Erythroxylon coca on oxygen utilization rate, mice, dogs</subject><subject>Plant Extracts - pharmacology</subject><subject>Plants, Medicinal</subject><subject>Respiration - drug effects</subject><issn>0022-3549</issn><issn>1520-6017</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1PGzEQhq2qFQ20V26V9tTbpvZ6vfYeSxS-igCJVDlaXntMDc462JuW_HtMNwL1UHGawzzvK80zCB0SPCUYV9_u1mlaNRhzghsi3qEJYRUuG0z4ezTJQFVSVrcf0X5KdxjjBjO2h_Y4bjmjdIJ-HLngw63Tyhdza0EPqQi2uAy98vfKB2fKWegH5XrX3xbHUenBhf4vM4_b4VcMj1sf-kIHrT6hD1b5BJ938wD9PJ4vZqflxdXJ2ez7RalrJkQJ0AlmBSWc1qLtBFG6a7SgqqZGKG7BNrTDpKOq0kZwo7QxQKztDK01aYAeoK9j7zqGhw2kQa5c0uC96iFskuR1PrJq2zdBQhkXFeUZnI6gjiGlCFauo1upuJUEy2fNMmuWr5pz4MuuedOtwLzgO6953477P87D9o02eX598093OWZdGuDxJavivWw45UwuL0_k0ZLMFgu-lNeZFyMP2flvB1Em7aDXYFzM_5QmuP-d8QTqgKxB</recordid><startdate>198206</startdate><enddate>198206</enddate><creator>Harland, Ernest C.</creator><creator>Murphy, James C.</creator><creator>Elsohly, Hala</creator><creator>Greubel, Deborah</creator><creator>Turner, Carlton E.</creator><creator>Watson, E.S.</creator><general>Elsevier Inc</general><general>Wiley Subscription Services, Inc., A Wiley Company</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>198206</creationdate><title>Biological Effects of Nonalkaloid-Containing Fractions of Erythroxylon coca</title><author>Harland, Ernest C. ; Murphy, James C. ; Elsohly, Hala ; Greubel, Deborah ; Turner, Carlton E. ; Watson, E.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4588-eeb85f83173489b81acb6c83a43d8a7fef63b01b3a2cd87dacdde1ffbd34c16e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Blood Glucose - metabolism</topic><topic>Blood Pressure - drug effects</topic><topic>CNS activity-effect of nonalkaloid-containing fractions of Erythroxylon coca</topic><topic>Coca</topic><topic>Dogs</topic><topic>effects</topic><topic>Erythroxylon coca-biological effects of nonalkaloid-containing fractions</topic><topic>Heart Rate - drug effects</topic><topic>Hemodynamics - drug effects</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred ICR</topic><topic>Motor Activity - drug effects</topic><topic>Nonalkaloids-fractions in Erythroxylon coca</topic><topic>Nonalkaloids—fractions in Erythroxylon coca, effects</topic><topic>Oxygen Consumption - drug effects</topic><topic>Oxygen utilization rate-effects of Erythroxylon coca on oxygen utilization rate</topic><topic>Oxygen utilization rate—effects of Erythroxylon coca on oxygen utilization rate, mice, dogs</topic><topic>Plant Extracts - pharmacology</topic><topic>Plants, Medicinal</topic><topic>Respiration - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Harland, Ernest C.</creatorcontrib><creatorcontrib>Murphy, James C.</creatorcontrib><creatorcontrib>Elsohly, Hala</creatorcontrib><creatorcontrib>Greubel, Deborah</creatorcontrib><creatorcontrib>Turner, Carlton E.</creatorcontrib><creatorcontrib>Watson, E.S.</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pharmaceutical sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Harland, Ernest C.</au><au>Murphy, James C.</au><au>Elsohly, Hala</au><au>Greubel, Deborah</au><au>Turner, Carlton E.</au><au>Watson, E.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biological Effects of Nonalkaloid-Containing Fractions of Erythroxylon coca</atitle><jtitle>Journal of pharmaceutical sciences</jtitle><addtitle>J. Pharm. Sci</addtitle><date>1982-06</date><risdate>1982</risdate><volume>71</volume><issue>6</issue><spage>677</spage><epage>679</epage><pages>677-679</pages><issn>0022-3549</issn><eissn>1520-6017</eissn><abstract>Water soluble nonalkaloid fractions of Erythroxylon coca were screened in mice for their effects on oxygen utilization and central nervous system (CNS) activity. The fractions were screened in dogs for cardiovascular, blood glucose, and respiratory changes. No CNS effects were demonstrated in mice; however, there was a reduction in the oxygen utilization rate. Intravenous administration of the extract to dogs produced hyperglycemia, a reduction in heart rate, and a decrease in blood pressure. No substantial change in the respiratory rate and tidal or minute volumes were observed.</abstract><cop>Washington</cop><pub>Elsevier Inc</pub><pmid>7097533</pmid><doi>10.1002/jps.2600710618</doi><tpages>3</tpages></addata></record> |
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| ispartof | Journal of pharmaceutical sciences, 1982-06, Vol.71 (6), p.677-679 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | Animals Blood Glucose - metabolism Blood Pressure - drug effects CNS activity-effect of nonalkaloid-containing fractions of Erythroxylon coca Coca Dogs effects Erythroxylon coca-biological effects of nonalkaloid-containing fractions Heart Rate - drug effects Hemodynamics - drug effects Male Mice Mice, Inbred ICR Motor Activity - drug effects Nonalkaloids-fractions in Erythroxylon coca Nonalkaloids—fractions in Erythroxylon coca, effects Oxygen Consumption - drug effects Oxygen utilization rate-effects of Erythroxylon coca on oxygen utilization rate Oxygen utilization rate—effects of Erythroxylon coca on oxygen utilization rate, mice, dogs Plant Extracts - pharmacology Plants, Medicinal Respiration - drug effects |
| title | Biological Effects of Nonalkaloid-Containing Fractions of Erythroxylon coca |
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