The effect of pH on platelet and coagulation factor activities
After observing that lavage of the stomach with alkaline solutions has a beneficial effect on the control of gastric hemorrhage, we examined the platelet and coagulation factor activities under conditions of lower and elevated pH. The results showed that change of the pH from acidosis to 7.0 and eve...
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| Veröffentlicht in: | The American journal of surgery 1978-08, Vol.136 (2), p.257-259 |
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| container_title | The American journal of surgery |
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| creator | Chaimoff, Chaim Creter, Draga Djaldetti, Meir |
| description | After observing that lavage of the stomach with alkaline solutions has a beneficial effect on the control of gastric hemorrhage, we examined the platelet and coagulation factor activities under conditions of lower and elevated pH. The results showed that change of the pH from acidosis to 7.0 and even to slight alkalosis induces platelet aggregation, platelet calcium and serotonin release, as well as platelet factor III availability. The prothrombin and partial thromboplastin times approached normal levels, whereas the fibrinogen level did not change significantly. The results obtained may serve as an explanation for the control of the intragastric bleeding in patients treated by maintenance of their gastric pH at 7.0. |
| doi_str_mv | 10.1016/0002-9610(78)90241-6 |
| format | Article |
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The results showed that change of the pH from acidosis to 7.0 and even to slight alkalosis induces platelet aggregation, platelet calcium and serotonin release, as well as platelet factor III availability. The prothrombin and partial thromboplastin times approached normal levels, whereas the fibrinogen level did not change significantly. The results obtained may serve as an explanation for the control of the intragastric bleeding in patients treated by maintenance of their gastric pH at 7.0.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/0002-9610(78)90241-6</identifier><identifier>PMID: 28678</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Blood Coagulation Factors - metabolism ; Blood Coagulation Tests ; Blood Platelets - metabolism ; Calcium - metabolism ; Epinephrine - pharmacology ; Gastrointestinal Hemorrhage - therapy ; Humans ; Hydrogen-Ion Concentration ; Platelet Aggregation - drug effects ; Serotonin - metabolism ; Thromboplastin - metabolism</subject><ispartof>The American journal of surgery, 1978-08, Vol.136 (2), p.257-259</ispartof><rights>1978</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c421t-2fb0183ca91ef14188e7f2c9f66c687605a3afeca6d2d5aa6aa33ce41f6555d03</citedby><cites>FETCH-LOGICAL-c421t-2fb0183ca91ef14188e7f2c9f66c687605a3afeca6d2d5aa6aa33ce41f6555d03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/0002961078902416$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28678$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chaimoff, Chaim</creatorcontrib><creatorcontrib>Creter, Draga</creatorcontrib><creatorcontrib>Djaldetti, Meir</creatorcontrib><title>The effect of pH on platelet and coagulation factor activities</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>After observing that lavage of the stomach with alkaline solutions has a beneficial effect on the control of gastric hemorrhage, we examined the platelet and coagulation factor activities under conditions of lower and elevated pH. The results showed that change of the pH from acidosis to 7.0 and even to slight alkalosis induces platelet aggregation, platelet calcium and serotonin release, as well as platelet factor III availability. The prothrombin and partial thromboplastin times approached normal levels, whereas the fibrinogen level did not change significantly. The results obtained may serve as an explanation for the control of the intragastric bleeding in patients treated by maintenance of their gastric pH at 7.0.</description><subject>Blood Coagulation Factors - metabolism</subject><subject>Blood Coagulation Tests</subject><subject>Blood Platelets - metabolism</subject><subject>Calcium - metabolism</subject><subject>Epinephrine - pharmacology</subject><subject>Gastrointestinal Hemorrhage - therapy</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Platelet Aggregation - drug effects</subject><subject>Serotonin - metabolism</subject><subject>Thromboplastin - metabolism</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD9PwzAQxS1EBaXwCWDwhGAI2E5iO0slVAFFqsRSZst1zmCUxsFOKvHtcf-oI4tPvvfu6e6H0A0lD5RQ_kgIYVnFKbkT8r4irKAZP0FjKkWVUSnzUzQ-Ws7RRYzf6UtpkZ-hEZNcyDGaLr8Ag7Vgeuwt7ubYt7hrdA8N9Fi3NTZefw6p4ZJgtel9wOl1G9c7iJdoZHUT4epQJ-jj5Xk5m2eL99e32dMiMwWjfcbsilCZG11RsLRIu4GwzFSWc8Ol4KTUuU47aF6zutSaa53nBgpqeVmWNckn6Haf2wX_M0Ds1dpFA02jW_BDVKIgJeNEJGOxN5rgYwxgVRfcWodfRYnaQlNbImpLRAmpdtAUT2PXh_xhtYb6OLSjlNTpXoV04sZBUNE4aA3ULiRwqvbu__g_o8t6iw</recordid><startdate>197808</startdate><enddate>197808</enddate><creator>Chaimoff, Chaim</creator><creator>Creter, Draga</creator><creator>Djaldetti, Meir</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>197808</creationdate><title>The effect of pH on platelet and coagulation factor activities</title><author>Chaimoff, Chaim ; Creter, Draga ; Djaldetti, Meir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c421t-2fb0183ca91ef14188e7f2c9f66c687605a3afeca6d2d5aa6aa33ce41f6555d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Blood Coagulation Factors - metabolism</topic><topic>Blood Coagulation Tests</topic><topic>Blood Platelets - metabolism</topic><topic>Calcium - metabolism</topic><topic>Epinephrine - pharmacology</topic><topic>Gastrointestinal Hemorrhage - therapy</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Platelet Aggregation - drug effects</topic><topic>Serotonin - metabolism</topic><topic>Thromboplastin - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chaimoff, Chaim</creatorcontrib><creatorcontrib>Creter, Draga</creatorcontrib><creatorcontrib>Djaldetti, Meir</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chaimoff, Chaim</au><au>Creter, Draga</au><au>Djaldetti, Meir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of pH on platelet and coagulation factor activities</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>1978-08</date><risdate>1978</risdate><volume>136</volume><issue>2</issue><spage>257</spage><epage>259</epage><pages>257-259</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>After observing that lavage of the stomach with alkaline solutions has a beneficial effect on the control of gastric hemorrhage, we examined the platelet and coagulation factor activities under conditions of lower and elevated pH. The results showed that change of the pH from acidosis to 7.0 and even to slight alkalosis induces platelet aggregation, platelet calcium and serotonin release, as well as platelet factor III availability. The prothrombin and partial thromboplastin times approached normal levels, whereas the fibrinogen level did not change significantly. The results obtained may serve as an explanation for the control of the intragastric bleeding in patients treated by maintenance of their gastric pH at 7.0.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28678</pmid><doi>10.1016/0002-9610(78)90241-6</doi><tpages>3</tpages></addata></record> |
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| ispartof | The American journal of surgery, 1978-08, Vol.136 (2), p.257-259 |
| issn | 0002-9610 1879-1883 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Blood Coagulation Factors - metabolism Blood Coagulation Tests Blood Platelets - metabolism Calcium - metabolism Epinephrine - pharmacology Gastrointestinal Hemorrhage - therapy Humans Hydrogen-Ion Concentration Platelet Aggregation - drug effects Serotonin - metabolism Thromboplastin - metabolism |
| title | The effect of pH on platelet and coagulation factor activities |
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