Alteration of the erythrocyte membrane during Newcastle disease virus-induced hemolysis
In attempting to explain the mechanism whereby hemoglobin is released during NDV-induced hemolysis it was found that marker substances like albumin or myoglobin with diameters larger than 30 A are retained in the erythrocyte membrane, whereas low molecular weight material is released. This indicates...
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| Veröffentlicht in: | Medical microbiology and immunology 1978-07, Vol.165 (2), p.101-109 |
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| container_title | Medical microbiology and immunology |
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| creator | Sziegoleit, A Füssle, R Rott, R |
| description | In attempting to explain the mechanism whereby hemoglobin is released during NDV-induced hemolysis it was found that marker substances like albumin or myoglobin with diameters larger than 30 A are retained in the erythrocyte membrane, whereas low molecular weight material is released. This indicates that NDV-induced hemolysis does not result in the formation of membrane lesions but rather in the alteration of membrane permeability. A prerequisite for this process is the insertion of viral envelope components into the cell membrane. NDV-induced hemolysis can be enhanced by virus-specific antibodies and complement. In this case the release of marker substances is due to membrane lesions since large molecules also are released from the erythrocytes. |
| doi_str_mv | 10.1007/BF02122745 |
| format | Article |
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This indicates that NDV-induced hemolysis does not result in the formation of membrane lesions but rather in the alteration of membrane permeability. A prerequisite for this process is the insertion of viral envelope components into the cell membrane. NDV-induced hemolysis can be enhanced by virus-specific antibodies and complement. 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This indicates that NDV-induced hemolysis does not result in the formation of membrane lesions but rather in the alteration of membrane permeability. A prerequisite for this process is the insertion of viral envelope components into the cell membrane. NDV-induced hemolysis can be enhanced by virus-specific antibodies and complement. In this case the release of marker substances is due to membrane lesions since large molecules also are released from the erythrocytes.</description><subject>Animals</subject><subject>Aprotinin - metabolism</subject><subject>Cell Membrane Permeability</subject><subject>Dipeptides - metabolism</subject><subject>Erythrocyte Membrane - metabolism</subject><subject>Erythrocyte Membrane - physiology</subject><subject>Erythrocytes - immunology</subject><subject>Erythrocytes - metabolism</subject><subject>Erythrocytes - physiology</subject><subject>Hemoglobins - metabolism</subject><subject>Hemolysis</subject><subject>Molecular Weight</subject><subject>Myoglobin - metabolism</subject><subject>Newcastle disease virus - immunology</subject><subject>Serum Albumin - metabolism</subject><subject>Sheep</subject><issn>0300-8584</issn><issn>1432-1831</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1978</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkE1Lw0AURQfxq1Y3rl3MyoUQfW9mkpksa7EqFN0UXIZM8mJHkqbOJEr-vZEWXV24HC6Xw9glwi0C6Lv7BQgUQqv4gE1QSRGhkXjIJiABIhMbdcrOQvgAQJ0IOGHHEnSi4gl7m9Ud-bxz7Ya3Fe_WxMkP3dq3xdARb6ixPt8QL3vvNu_8hb6LPHT1WLhAeSD-5XwfIrcp-4JKvqamrYfgwjk7qvI60MU-p2y1eFjNn6Ll6-PzfLaMCmGwi6xSUqeIFuMkFWRTUypAo1JVpSKXBqxMrBZxhWlsoKoElgLKlBQWiQUtp-x6N7v17WdPocsaFwqq6_Fz24dMK4gFgBrBmx1Y-DYET1W29a7J_ZAhZL8Os3-HI3y1X-1tQ-UfupMmfwDgtWtO</recordid><startdate>19780704</startdate><enddate>19780704</enddate><creator>Sziegoleit, A</creator><creator>Füssle, R</creator><creator>Rott, R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19780704</creationdate><title>Alteration of the erythrocyte membrane during Newcastle disease virus-induced hemolysis</title><author>Sziegoleit, A ; Füssle, R ; Rott, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c281t-b4437911b15692eb98d4018494f92a380b36b725f19580ff21d20d9e41c6b073</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1978</creationdate><topic>Animals</topic><topic>Aprotinin - metabolism</topic><topic>Cell Membrane Permeability</topic><topic>Dipeptides - metabolism</topic><topic>Erythrocyte Membrane - metabolism</topic><topic>Erythrocyte Membrane - physiology</topic><topic>Erythrocytes - immunology</topic><topic>Erythrocytes - metabolism</topic><topic>Erythrocytes - physiology</topic><topic>Hemoglobins - metabolism</topic><topic>Hemolysis</topic><topic>Molecular Weight</topic><topic>Myoglobin - metabolism</topic><topic>Newcastle disease virus - immunology</topic><topic>Serum Albumin - metabolism</topic><topic>Sheep</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sziegoleit, A</creatorcontrib><creatorcontrib>Füssle, R</creatorcontrib><creatorcontrib>Rott, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical microbiology and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sziegoleit, A</au><au>Füssle, R</au><au>Rott, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alteration of the erythrocyte membrane during Newcastle disease virus-induced hemolysis</atitle><jtitle>Medical microbiology and immunology</jtitle><addtitle>Med Microbiol Immunol</addtitle><date>1978-07-04</date><risdate>1978</risdate><volume>165</volume><issue>2</issue><spage>101</spage><epage>109</epage><pages>101-109</pages><issn>0300-8584</issn><eissn>1432-1831</eissn><abstract>In attempting to explain the mechanism whereby hemoglobin is released during NDV-induced hemolysis it was found that marker substances like albumin or myoglobin with diameters larger than 30 A are retained in the erythrocyte membrane, whereas low molecular weight material is released. 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| identifier | ISSN: 0300-8584 |
| ispartof | Medical microbiology and immunology, 1978-07, Vol.165 (2), p.101-109 |
| issn | 0300-8584 1432-1831 |
| language | eng |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Animals Aprotinin - metabolism Cell Membrane Permeability Dipeptides - metabolism Erythrocyte Membrane - metabolism Erythrocyte Membrane - physiology Erythrocytes - immunology Erythrocytes - metabolism Erythrocytes - physiology Hemoglobins - metabolism Hemolysis Molecular Weight Myoglobin - metabolism Newcastle disease virus - immunology Serum Albumin - metabolism Sheep |
| title | Alteration of the erythrocyte membrane during Newcastle disease virus-induced hemolysis |
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