The Refractory State of Luteal Cells Isolated from Rhesus Monkeys after Prolonged Exposure to Chorionic Gonadotropin during Early Pregnancy

The Refractory State of Luteal Cells Isolated from Rhesus Monkeys after Prolonged Exposure to Chorionic Gonadotropin during Early Pregnancy

To assess the regractory state of the rhesus monkey corpus luteum following 2-3 weeks exposure to endogenous macaque chorionic gonadotropin (mCG) in early pregnancy, we investigated in vitro the effect of hCG, dibutyryl cyclic AMP (dbcAMP) and pregnenolone on progesterone production by luteal cells...

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Veröffentlicht in:Biology of reproduction 1978-06, Vol.18 (5), p.858-864
Hauptverfasser: Stouffer, R L, Nixon, W E, Hodgen, G D
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Bucladesine - pharmacology
Cells, Cultured
Chorionic Gonadotropin - pharmacology
Corpus Luteum - metabolism
Female
Haplorhini
Macaca mulatta
Menstruation - drug effects
Pregnancy
Pregnancy, Animal - drug effects
Pregnenolone - pharmacology
Progesterone - biosynthesis
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Zusammenfassung:To assess the regractory state of the rhesus monkey corpus luteum following 2-3 weeks exposure to endogenous macaque chorionic gonadotropin (mCG) in early pregnancy, we investigated in vitro the effect of hCG, dibutyryl cyclic AMP (dbcAMP) and pregnenolone on progesterone production by luteal cells isolated from monkeys during early pregnancy (Days 22-29 of gestation). For comparison, luteal cells obtained during the menstrual cycle (Days 16-19 postmenses) and at term pregnancy (Days 160-165 of gestation) were also studied. Under control conditions, luteal cells obtained on Days 22-24 of pregnancy produced significantly (P
ISSN:0006-3363
1529-7268
DOI:10.1095/biolreprod18.5.858